Patents by Inventor Donna Leippe

Donna Leippe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and methods for assaying redox state of metabolically active cells and methods for measuring NAD(P)/NAD(P)H
    Patent number: 9951372
    Abstract: The present invention provides compounds and methods for assaying redox state of metabolically active cells and methods for assaying enzyme activity and/or metabolite level by coupling to redox defining co-factor NAD(P)/NAD(P)H measurement.
    Type: Grant
    Filed: September 20, 2013
    Date of Patent: April 24, 2018
    Assignee: PROMEGA CORPORATION
    Inventors: Wenhui Zhou, Jolanta Vidugiriene, Helene A. Benink, James J. Cali, Sarah Duellman, Dieter Klaubert, Donna Leippe, Martha O'Brien, John Shultz, Mary Sobol
  • Compounds and methods for assaying redox state of metabolically active cells and methods for measuring NAD(P)/NAD(P)H
    Patent number: 9273343
    Abstract: The present invention provides compounds and methods for assaying redox state of metabolically active cells and methods for assaying enzyme activity and/or metabolite level by coupling to redox defining co-factor NAD(P)/NAD(P)H measurement.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: March 1, 2016
    Assignee: PROMEGA CORPORATION
    Inventors: James J. Cali, Sarah Duellman, Dieter Klaubert, Donna Leippe, Martha O'Brien, John Shultz, Jolanta Vidugiriene, Wenhui Zhou, Mary Sobol
  • COMPOUNDS AND METHODS FOR ASSAYING REDOX STATE OF METABOLICALLY ACTIVE CELLS AND METHODS FOR MEASURING NAD(P)/NAD(P)H
    Publication number: 20140093894
    Abstract: The present invention provides compounds and methods for assaying redox state of metabolically active cells and methods for assaying enzyme activity and/or metabolite level by coupling to redox defining co-factor NAD(P)/NAD(P)H measurement.
    Type: Application
    Filed: September 20, 2013
    Publication date: April 3, 2014
    Applicant: PROMEGA CORPORATION
    Inventors: Helene A. BENINK, James J. CALI, Sarah DUELLMAN, Dieter KLAUBERT, Donna LEIPPE, Martha O'BRIEN, John SHULTZ, Jolanta VIDUGIRIENE, Wenhui ZHOU, Mary SOBOL
  • COMPOUNDS AND METHODS FOR ASSAYING REDOX STATE OF METABOLICALLY ACTIVE CELLS AND METHODS FOR MEASURING NAD(P)/NAD(P)H
    Publication number: 20130130289
    Abstract: The present invention provides compounds and methods for assaying redox state of metabolically active cells and methods for assaying enzyme activity and/or metabolite level by coupling to redox defining co-factor NAD(P)/NAD(P)H measurement.
    Type: Application
    Filed: August 31, 2012
    Publication date: May 23, 2013
    Applicant: PROMEGA CORPORATION
    Inventors: Helene A. BENINK, James J. CALI, Sarah DUELLMAN, Dieter KLAUBERT, Donna LEIPPE, Martha O'BRIEN, John SHULTZ, Jolanta VIDUGIRIENE, Wenhui ZHOU, Mary SOBOL
  • Detection of nucleic acid hybrids
    Publication number: 20050214753
    Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of a predetermined nucleic acid. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, speciation, determination of viral load, genotyping, medical marker diagnostics, and the like.
    Type: Application
    Filed: February 22, 2001
    Publication date: September 29, 2005
    Applicant: Promega Corporation
    Inventors: John Shultz, Martin Lewis, Donna Leippe, Michelle Mandrekar, Daniel Kephart, Richard Rhodes, Christine Andrews, James Hartnett, Trent Gu, Ryan Olson, Keith Wood, Roy Welch
  • Detection of nucleic acid hybrids
    Patent number: 6730479
    Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of a predetermined nucleic acid. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, speciation, determination of viral load, genotyping, medical marker diagnostics, and the like.
    Type: Grant
    Filed: February 22, 2001
    Date of Patent: May 4, 2004
    Assignee: Promega Corporation
    Inventors: John William Shultz, Martin K. Lewis, Donna Leippe, Michelle Mandrekar, Daniel Kephart, Richard Byron Rhodes, Christine Ann Andrews, James Robert Hartnett, Trent Gu, Ryan J. Olson, Keith V. Wood, Roy Welch
  • Multiplex method for nucleic acid detection
    Patent number: 6653078
    Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of predetermined nucleic acid target sequences using a multiplex assay format. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, speciation, genotyping, medical marker diagnostics, and the like.
    Type: Grant
    Filed: February 20, 2001
    Date of Patent: November 25, 2003
    Assignee: Promega Corporation
    Inventors: Martin K. Lewis, Daniel Kephart, Richard Byron Rhodes, John William Shultz, Donna Leippe, Michelle Mandrekar, Christine Ann Andrews, James Robert Hartnett, Trent Gu, Keith V. Wood, Roy Welch
  • Exogenous nucleic acid detection
    Publication number: 20030203358
    Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of a predetermined exogenous nucleic acid. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, determination of viral load, genotyping, medical marker diagnostics, and the like.
    Type: Application
    Filed: February 9, 2001
    Publication date: October 30, 2003
    Applicant: Promega Corporation
    Inventors: John William Shultz, Martin K. Lewis, Donna Leippe, Michelle Mandrekar, Daniel Kephart, Richard Byron Rhodes, Christine Ann Andrews, James Robert Hartnett, Trent Gu, Ryan J. Olson, Keith V. Wood, Roy Welch
  • Multiplex method for nucleic acid detection
    Publication number: 20030194699
    Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of predetermined nucleic acid target sequences using a multiplex assay format. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, speciation, genotyping, medical marker diagnostics, and the like.
    Type: Application
    Filed: February 20, 2001
    Publication date: October 16, 2003
    Applicant: Promega Corporation
    Inventors: Martin K. Lewis, Daniel Kephart, Richard Byron Rhodes, John William Shultz, Donna Leippe, Michelle Mandrekar, Christine Ann Andrews, James Robert Hartnett, Trent Gu, Keith V. Wood, Roy Welch
  • Detection of nucleic acid hybrids
    Publication number: 20030077621
    Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of a predetermined endogenous nucleic acid. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, spieciation, determination of viral load, genotyping, medical marker diagnostics, and the like.
    Type: Application
    Filed: May 20, 2002
    Publication date: April 24, 2003
    Applicant: Promega Corporation
    Inventors: John William Shultz, Martin K. Lewis, Donna Leippe, Michelle Mandrekar, Daniel Kephart, Richard Byron Rhodes, Christine Ann Andrews, James Robert Hartnett, Trent Gu, Ryan J. Olson, Keith V. Wood, Roy Welch
  • Detection of nucleic acid hybrids
    Patent number: 6391551
    Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of a predetermined endogenous nucleic acid. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, speciation, determination of viral load, genotyping, medical marker diagnostics, and the like.
    Type: Grant
    Filed: August 25, 1999
    Date of Patent: May 21, 2002
    Assignee: Promega Corporation
    Inventors: John William Shultz, Martin K. Lewis, Donna Leippe, Michelle Mandrekar, Daniel Kephart, Richard Byron Rhodes, Christine Ann Andrews, James Robert Hartnett, Trent Gu, Ryan J. Olson, Keith V. Wood, Roy Welch
  • Nucleic acid detection
    Patent number: 6312902
    Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of a predetermined nucleic acid. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, speciation, determination of viral load, genotyping, medical marker diagnostics, and the like.
    Type: Grant
    Filed: September 27, 1999
    Date of Patent: November 6, 2001
    Assignee: Promega Corporation
    Inventors: John William Shultz, Martin K. Lewis, Donna Leippe, Michelle Mandrekar, Daniel Kephart, Richard Byron Rhodes, Christine Ann Andrews, James Robert Hartnett, Trent Gu, Ryan J. Olson, Roy Welch
  • Detection of nucleic acid hybrids
    Publication number: 20010031470
    Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of a predetermined nucleic acid. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, speciation, determination of viral load, genotyping, medical marker diagnostics, and the like.
    Type: Application
    Filed: February 22, 2001
    Publication date: October 18, 2001
    Applicant: Promega Corporation
    Inventors: John William Shultz, Martin K. Lewis, Donna Leippe, Michelle Mandrekar, Daniel Kephart, Richard Byron Rhodes, Christine Ann Andrews, James Robert Hartnett, Trent Gu, Ryan J. Olson, Keith V. Wood, Roy Welch
  • Deploymerization method for nucleic acid detection of an amplified nucleic acid target
    Patent number: 6277578
    Abstract: The detection of enhanced, targeted predetermined nucleic acid sequences in nucleic acid target hybrids, and the various applications of target nucleic acid enhancement are disclosed.
    Type: Grant
    Filed: October 29, 1999
    Date of Patent: August 21, 2001
    Assignee: Promega Corporation
    Inventors: John William Shultz, Martin K. Lewis, Donna Leippe, Michelle Mandrekar, Christine Ann Andrews, James Robert Hartnett, Roy Welch
  • Multiplex method for nucleic acid detection
    Patent number: 6270973
    Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of predetermined nucleic acid target sequences using a multiplex assay format. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, speciation, genotyping, medical marker diagnostics, and the like.
    Type: Grant
    Filed: September 27, 1999
    Date of Patent: August 7, 2001
    Assignee: Promega Corporation
    Inventors: Martin K. Lewis, Daniel Kephart, Richard Byron Rhodes, John William Shultz, Donna Leippe, Michelle Mandrekar, Christine Ann Andrews, James Robert Hartnett, Trent Gu, Keith V. Wood, Roy Welch
  • Exogenous nucleic acid detection
    Patent number: 6270974
    Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of a predetermined exogenous nucleic acid. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, determination of viral load, genotyping, medical marker diagnostics, and the like.
    Type: Grant
    Filed: September 27, 1999
    Date of Patent: August 7, 2001
    Assignee: Promega Corporation
    Inventors: John William Shultz, Martin K. Lewis, Donna Leippe, Michelle Mandrekar, Daniel Kephart, Richard Byron Rhodes, Christine Ann Andrews, James Robert Hartnett, Trent Gu, Ryan J. Olson, Keith V. Wood, Roy Welch
  • Analytical methods and materials for nucleic acid detection
    Patent number: 6268146
    Abstract: Mass spectrometric, absorbance spectroscopic and fluorescence spectroscopic processes are disclosed to detect the depolymerization of a nucleic acid hybrid in order to qualitatively and quantitatively assay for the presence of a predetermined nucleic acid target. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, speciation, determination of viral load, genotyping, medical marker diagnostics, and the like, including multiplexed assays.
    Type: Grant
    Filed: November 22, 1999
    Date of Patent: July 31, 2001
    Assignee: Promega Corporation
    Inventors: John William Shultz, Martin K. Lewis, Michelle Mandrekar, Donna Leippe, Roderick R. Smith, Jr., Roy Welch
  • Detection of nucleic acid hybrids
    Patent number: 6235480
    Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of a predetermined nucleic acid. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, speciation, determination of viral load, genotyping, medical marker diagnostics, and the like.
    Type: Grant
    Filed: July 21, 1999
    Date of Patent: May 22, 2001
    Assignee: Promega Corporation
    Inventors: John William Shultz, Martin K. Lewis, Donna Leippe, Michelle Mandrekar, Daniel Kephart, Richard Byron Rhodes, Christine Ann Andrews, James Robert Hartnett, Trent Gu, Ryan J. Olson, Keith V. Wood, Roy Welch