Patents by Inventor Donna M. Trenkler

Donna M. Trenkler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of cryopreserving hepatocytes
    Patent number: 6136525
    Abstract: An artificial liver support system is described herein which comprises cryopreserved hepatocytes having an initial viability of 80-99%. Further disclosed are hepatocytes cryopreserved by dispensing hepatocytes into freezing containers, freezing the containers from between minus 50 to minus 90 degrees Celsius, storing the containers in liquid or vapor nitrogen, thawing the cryopreserved hepatocytes when ready for use and removing residual cryoprotectant media.
    Type: Grant
    Filed: August 2, 1999
    Date of Patent: October 24, 2000
    Assignee: Circe Biomedical, Inc.
    Inventors: Claudy Jean-Paul Mullon, Shawn Paul Cain, Timothy Jon Perlman, Hugo O. Jauregui, Sharda Naik, Henry A. Santangini, Donna M. Trenkler
  • Isolation and culture of porcine hepatocytes
    Patent number: 6017760
    Abstract: A perfusion device such as a liver assist device containing a housing defining a perfusion inlet and a perfusion outlet, a porous membrane structure mounted within said housing to define a perfusion compartment and an adjacent hepatocyte compartment, and porcine hepatocytes isolated from a porcine liver by retrograde perfusion.
    Type: Grant
    Filed: October 10, 1995
    Date of Patent: January 25, 2000
    Assignee: Rhode Island Hospital
    Inventors: Hugo O. Jauregui, Sharda Naik, Henry Santangini, Donna M. Trenkler
  • Cryopreserved hepatocytes and high viability and metabolic activity
    Patent number: 5795711
    Abstract: An artificial liver support system is described herein which comprises cryopreserved hepatocytes having an initial viability of 80-99% and a metabolic activity 50-80% of fresh hepatocytes. Further disclosed are hepatocytes cryopreserved by dispensing hepatocytes into freezing containers, freezing the containers from between minus 50 to minus 90 degrees Celsius, storing the containers in liquid or vapor nitrogen, thawing the cryopreserved hepatocytes when ready for use and removing residual cryoprotectant media.
    Type: Grant
    Filed: April 4, 1996
    Date of Patent: August 18, 1998
    Assignee: Circe Biomedical, Inc.
    Inventors: Claudy Jean-Paul Mullon, Shawn Paul Cain, Timothy Jon Perlman, Hugo O. Jauregui, Sharda Naik, Henry A. Santangini, Donna M. Trenkler