Patents by Inventor Donna T. Ward

Donna T. Ward has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VECTORIZED ANTIBODIES (vAb) AND USES THEREOF
    Publication number: 20230075314
    Abstract: The present disclosure provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody-like polypeptides, for the prevention and/or treatment of diseases and/or disorders.
    Type: Application
    Filed: April 29, 2020
    Publication date: March 9, 2023
    Inventors: Jinzhao Hou, Yanqun Shu, Todd Carter, Dinah Wen-Yee Sah, Po-Jen Yen, Donna T. Ward, Johanna L. Crimins
  • COMPOSITIONS FOR THE TREATMENT OF DISEASE
    Publication number: 20220395544
    Abstract: The invention provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody-like pol peptides, for the prevention and/or treatment of diseases and/or disorders.
    Type: Application
    Filed: April 8, 2022
    Publication date: December 15, 2022
    Applicant: Voyager Therapeutics, Inc.
    Inventors: Steven Paul, Donna T. Ward
  • COMPOSITIONS FOR THE TREATMENT OF DISEASE
    Publication number: 20220389449
    Abstract: The invention provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody-like polypeptides, for the prevention and/or treatment of diseases and/or disorders.
    Type: Application
    Filed: April 26, 2022
    Publication date: December 8, 2022
    Inventors: Steven Paul, Donna T. Ward
  • VECTORIZED EDITING OF NUCLEIC ACIDS TO CORRECT OVERT MUTATIONS
    Publication number: 20220333133
    Abstract: The disclosure relates to compositions, methods, and processes for the preparation, use, and/or formulation of adeno-associated virus (AAV) particle comprising a viral gene and a capsid, wherein the viral genome comprises at least one Vectorized Editing of Nucleic acids to correct Overt Mutations (VENOM) element.
    Type: Application
    Filed: September 3, 2020
    Publication date: October 20, 2022
    Inventors: Kelly BALES, Allen NUNNALLY, Donna T. WARD, Jennifer F. BRYAN
  • Compositions for the treatment of disease
    Patent number: 11326182
    Abstract: The invention provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody like polypeptides, for the prevention and/or treatment of diseases and/or disorders.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: May 10, 2022
    Assignee: Voyager Therapeutics, Inc.
    Inventors: Steven Paul, Donna T. Ward
  • Compositions for the treatment of disease
    Patent number: 11299751
    Abstract: The invention provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody-like polypeptides, for the prevention and/or treatment of diseases and/or disorders.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: April 12, 2022
    Assignee: Voyager Therapeutics, Inc.
    Inventors: Steven Paul, Donna T. Ward
  • CANNULA SYSTEM AND USE THEREOF
    Publication number: 20210361318
    Abstract: The present disclosure relates to cannula systems for delivery of a therapeutic agent to parenchymal tissue of a target subject. In certain embodiments, the cannula system is for delivery of a therapeutic agent to parenchymal tissue in the spine of a target subject. In certain embodiments, the cannula system includes a cannula positioning guide (CPG) useful in the delivery of a therapeutic agent to a localized target tissue of a subject. The guide may be used in a surgical suite or during a surgical procedure.
    Type: Application
    Filed: July 2, 2019
    Publication date: November 25, 2021
    Inventors: Holger Patzke, Steven M. Hersch, Jenna Carroll Soper, Adrian Philip Kells, Nicholas Boulis, Donna T. Ward
  • IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS
    Publication number: 20210254056
    Abstract: The present invention provides methods and compositions for the evaluation, alteration and/or optimization of gene signaling. Methods and systems are also provided which exploit the information generated in the identification of new targets and non-canonical signaling pathways.
    Type: Application
    Filed: May 4, 2018
    Publication date: August 19, 2021
    Inventors: Yuting LIU, Alla SIGOVA, Charles W. O'DONNELL, Cynthia SMITH, Gavin WHISSELL, Brett CHEVALIER, Jennifer F. BRYAN, Donna T. WARD
  • RNAi CONJUGATES, PARTICLES AND FORMULATIONS THEREOF
    Publication number: 20200339990
    Abstract: Particles, including nanoparticles and microparticles, and pharmaceutical formulations thereof, comprising conjugates of an RNAi agent attached to a targeting moiety via a linker have been designed which can provide improved temporospatial delivery of the RNAi agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.
    Type: Application
    Filed: July 6, 2020
    Publication date: October 29, 2020
    Inventors: Sudhakar Kadiyala, Donna T. Ward
  • COMPOSITIONS FOR THE TREATMENT OF DISEASE
    Publication number: 20200165630
    Abstract: The invention provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody-like polypeptides, for the prevention and/or treatment of diseases and/or disorders.
    Type: Application
    Filed: April 28, 2017
    Publication date: May 28, 2020
    Inventors: Steven Paul, Donna T. Ward
  • METHODS AND COMPOSITIONS FOR TREATING INSECTS
    Publication number: 20190233815
    Abstract: Provided herein are methods and compositions for modulating gene expression in insects by administering a composition comprising an RNA effector molecule and a delivery agent. Methods are provided for controlling pest populations by inhibiting insect growth, development, survival, reproduction and/or viability. Also provided herein are methods for treating or preventing disease in an insect caused by a pathogen or by external factors (e.g., pollution, environment, stress, weather, etc.).
    Type: Application
    Filed: December 11, 2018
    Publication date: August 1, 2019
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Donna T. Ward, Jason Rhodes
  • COMPOSITIONS FOR THE TREATMENT OF DISEASE
    Publication number: 20190153471
    Abstract: The invention provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody like polypeptides, for the prevention and/or treatment of diseases and/or disorders.
    Type: Application
    Filed: April 28, 2017
    Publication date: May 23, 2019
    Inventors: Steven Paul, Donna T. Ward
  • Methods and compositions for treating insects
    Patent number: 10190118
    Abstract: Provided herein are methods and compositions for modulating gene expression in insects by administering a composition comprising an RNA effector molecule and a delivery agent. Methods are provided for controlling pest populations by inhibiting insect growth, development, survival, reproduction and/or viability. Also provided herein are methods for treating or preventing disease in an insect caused by a pathogen or by external factors (e.g., pollution, environment, stress, weather, etc.).
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: January 29, 2019
    Assignee: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Donna T. Ward, Jason Rhodes
  • RNAi CONJUGATES, PARTICLES AND FORMULATIONS THEREOF
    Publication number: 20180273948
    Abstract: Particles, including nanoparticles and microparticles, and pharmaceutical formulations thereof, comprising conjugates of an RNAi agent attached to a targeting moiety via a linker have been designed which can provide improved temporospatial delivery of the RNAi agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.
    Type: Application
    Filed: September 23, 2016
    Publication date: September 27, 2018
    Applicant: Tarveda Therapeutics, Inc.
    Inventors: Sudhakar Kadiyala, Donna T. Ward
  • COMPOSITIONS AND METHODS FOR GENOME EDITING
    Publication number: 20180258411
    Abstract: The present invention provides conjugates, nanoparticles and compositions comprising components of a CRISPR-Cas system; these compositions can be used for genetic editing in a cell or an organism.
    Type: Application
    Filed: September 23, 2016
    Publication date: September 13, 2018
    Inventors: Sudhakar Kadiyala, Mark T. Bilodeau, Donna T. Ward
  • COMPOSITIONS AND METHODS FOR IMMUNO-ONCOLOGY THERAPIES
    Publication number: 20180221503
    Abstract: The present invention relates to cancer immunotherapy. Conjugates and nanoparticles comprising active agents that can elicit a cancer specific immune response are provided. The conjugates comprise one or more targeting moieties that are connected to the active agents. Nanoparticles comprising the conjugates of the present invention are also provided to increase the delivery of the conjugates, and increase immunogenicity and lower toxicity.
    Type: Application
    Filed: July 29, 2016
    Publication date: August 9, 2018
    Inventors: Sudhakar Kadiyala, Donna T. Ward, Richard Wooster
  • COMPOSITIONS AND METHODS FOR IMMUNOMODULATION
    Publication number: 20180221508
    Abstract: The present invention relates to modulation of the tumor microenvironment to increase cancer specific immune responses. Conjugates, nanoparticles and formulations of the present invention relieve the inhibitory effect induced by tumor cells, and enhance antitumor immunity. The compostions provided herein can be used as immunotherapies, or as adjuvants used in conjunction with other immunotherapies such as peptide vaccines, cell vaccines and/or adoptive T cell transfer.
    Type: Application
    Filed: July 29, 2016
    Publication date: August 9, 2018
    Inventors: Sudhakar KADIYALA, Donna T. WARD
  • METHODS AND COMPOSITIONS FOR TREATING INSECTS
    Publication number: 20170204411
    Abstract: Provided herein are methods and compositions for modulating gene expression in insects by administering a composition comprising an RNA effector molecule and a delivery agent. Methods are provided for controlling pest populations by inhibiting insect growth, development, survival, reproduction and/or viability. Also provided herein are methods for treating or preventing disease in an insect caused by a pathogen or by external factors (e.g., pollution, environment, stress, weather, etc.).
    Type: Application
    Filed: November 7, 2016
    Publication date: July 20, 2017
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Donna T. Ward, Jason Rhodes
  • METHODS AND COMPOSITIONS FOR TREATING INSECTS
    Publication number: 20150011614
    Abstract: Provided herein are methods and compositions for modulating gene expression in insects by administering a composition comprising an RNA effector molecule and a delivery agent. Methods are provided for controlling pest populations by inhibiting insect growth, development, survival, reproduction and/or viability. Also provided herein are methods for treating or preventing disease in an insect caused by a pathogen or by external factors (e.g., pollution, environment, stress, weather, etc.).
    Type: Application
    Filed: September 25, 2014
    Publication date: January 8, 2015
    Inventors: Donna T. WARD, Jason Rhodes
  • Modulation of HIF1? and HIF2? expression
    Patent number: 8513400
    Abstract: Compounds, compositions and methods are provided for modulating the expression of HIF1? and/or HIF2?. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1? and HIF2?. Methods of using these compounds for modulation of HIF1? and/or HIF2? expression and for diagnosis and treatment of disease associated with expression of HIF1? and/or HIF2? are provided.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: August 20, 2013
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Donna T. Ward, Kenneth W. Dobie, Eric G. Marcusson, Susan M. Freier