Patents by Inventor Donny Strosberg

Donny Strosberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transgenic animals deficient in endogenous .beta..sub.3 -adrenergic receptor and uses thereof
    Patent number: 5789654
    Abstract: Disclosed a transgenic non-human mammal whose germ cells and somatic cells contain a knockout mutation in DNA encoding .beta..sub.3 -adrenergic receptor polypeptide.
    Type: Grant
    Filed: May 9, 1996
    Date of Patent: August 4, 1998
    Assignees: Beth Israel Hospital Association, Centre National de la Recherche Scientifique
    Inventors: Bradford B. Lowell, A. Donny Strosberg
  • Nucleotide sequences encoding the murine .beta.3-adrenergic receptor and their applications
    Patent number: 5691155
    Abstract: Nucleotide sequences encoding the murine .beta.3-adrenergic receptor are provided. Use of the sequences as probes, in vectors, and for the expression of peptides are discussed. Methods of screening substances for agonist or antagonist action towards .beta.3-adrenergic receptors, and for detecting the affinity of various substances for .beta.3-adrenergic receptors, are described.
    Type: Grant
    Filed: August 16, 1993
    Date of Patent: November 25, 1997
    Assignee: Centre National De La Recherche Scientifigue
    Inventors: Clara Nahmias, Laurent Jean Emorine, Arthur Donny Strosberg
  • Specific peptide fragment of the feline immunodeficiency virus (FIV), and its use as a diagnostic reagent
    Patent number: 5648209
    Abstract: Specific peptide fragment from the feline immunodeficiency virus (FIV), and its use as a diagnostic reagent.The said peptide fragment, derived from the Env protein of the Wo strain of the feline immunodeficiency virus (FIV) (peptide P253), corresponds to positions 693-709 of the said Env protein and exhibits the following sequence:Leu-Gly-X-Asn-Gln-Asn-Gln-Phe-Phe-X-Lys-Val-Pro-Ser-Ala-, in which X represents a cysteine or a serine, as follows:Leu-Gly-Cys-Asn-Gln-Asn-Gln-Phe-Phe-Cys-Lys-Val-Pro-Ser-Ala (SEQ ID NO: 1),Leu-Gly-Ser-Asn-Gln-Asn-Gln-Phe-Phe-Ser-Lys-Val-Pro-Ser-Ala (SEQ ID NO: 2),Leu-Gly-Cys-Asn-Gln-Asn-Gln-Phe-Phe-Ser-Lys-Val-Pro-Ser-Ala (SEQ ID NO: 3),Leu-Gly-Ser-Asn-Gln-Asn-Gln-Phe-Phe-Cys-Lys-Val-Pro-Ser-Ala (SEQ ID NO: 4).
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 15, 1997
    Assignee: Centre National de la Recherche Scientifique-CNRS
    Inventors: Alexandre Avrameas, Gianfranco Pancino, Pierre Sibille, Pierre Sonigo, Arthur Donny Strosberg
  • Polypeptides having a .beta.-adrenergic receptor activity in man, implicated in the lipolytic response, nucleic acids coding for these polypeptides and the use of these polypeptides for the screening of a substance active on these polypeptides
    Patent number: 5288607
    Abstract: Novel polypeptides having a .beta.-adrenergic receptor activity containing the sequence of 402 amino acids, or a fragment of this sequence, said fragment being such that, in particular, either it nonetheless includes the sites contained in said sequence and whose presence is necessary so that, when the fragment is exposed to the surface of a cell, it is capable of participating in the activation of the cyclase adenylate in the presence of an agonist, or it is likely to be recognized by antibodies which also recognize the above succession of 402 amino acids, but fail to recognize the .beta.1 adrenergic receptor and the .beta.2 adrenergic receptor. These polypeptides are useful for screening drugs which act on said polypeptides and for treating obesity, fat diabetes and hyperlipidemias.
    Type: Grant
    Filed: September 3, 1991
    Date of Patent: February 22, 1994
    Assignee: Centre National De La Recherche Scientifique
    Inventors: Laurent Emorine, Stefano Marullo, Donny Strosberg
  • Recombinant bacteria expressing functional R76 mammalian receptors on their surface
    Patent number: 5242822
    Abstract: The invention relates to a vector capable of being replicated in cultures of unicellular organisms, this vector containing a gene coding for a eucaryotic protein having the biological activity of a membrane receptor and interacting with a regulatory protein--called the G protein--able to bind molecules of guanosine triphosphate (GTP). The invention also relates to cell organisms transformed by the above vectors. It also relates to procedures for the detection of the capacity of a molecule to behave as a ligand for a receptor and a procedure for studying the affinity of a receptor for a ligand as well as a kit for detecting the possible affinity of a ligand for a receptor.
    Type: Grant
    Filed: March 25, 1991
    Date of Patent: September 7, 1993
    Assignee: Centre National De La Recherche Scientifique
    Inventors: Stefano Marullo, Colette Delavier, Laurent Emorine, Donny Strosberg