Abstract: Disclosed is a refrigerating device that includes: a refrigeration mechanism; and a cooling chamber. The cooling chamber is operatively coupled to the refrigeration mechanism using any or a combination of a latching mechanism and a screwing mechanism, and is configured to hold a load to be cooled. The refrigeration mechanism can be a thermo-electric assembly (TEA) and the device can include a proportional integral derivative (PID) controller to set and regulate temperature inside the cooling chamber. The cooling chamber can be a vacuum flask, open end of the vacuum flask configured to be thermally sealed with the TEA. The vacuum flask provides thermal insulation between the load and ambient environment. In an exemplary embodiment, the vacuum flask can be thermally sealed with the TEA by configuring the TEA in a collar of thermal insulation, the collar configured to hold the vacuum flask by means of threads configured on the collar and the vacuum flask.