Abstract: A method for manufacturing a semiconductor device and a semiconductor device produced thereby. For example and without limitation, various aspects of this disclosure provide methods for manufacturing a semiconductor device, and semiconductor devices produced thereby, that comprise forming an interposer including a reinforcement layer.

Abstract: The present disclosure relates to an organic electroluminescent device. The organic electroluminescent device of the present disclosure shows high luminous efficiency and good lifespan by comprising a specific combination of the plural kinds of host compounds and a specific hole transport compound.

Abstract: Methods for making a combinatorial antibody library from human germline segments are provided. Also provided are libraries of nucleic acid molecules compiled from germline segments encoding VL chains and libraries of nucleic acid molecules encoding VH chains, and resulting antibody libraries. The libraries are provided as addressable libraries. Methods for screening antibody libraries against a target protein antigen, and the identified or selected antibodies are provided.

Abstract: Methods for making a combinatorial antibody library from human germline segments are provided. Also provided are libraries of nucleic acid molecules compiled from germline segments encoding VL chains and libraries of nucleic acid molecules encoding VH chains, and resulting antibody libraries. The libraries are provided as addressable libraries. Methods for screening antibody libraries against a target protein antigen, and the identified or selected antibodies are provided.

Abstract: The present invention relates to a method for constructing an Fv library based on a combination of proteins, a method of screening a desired antibody using the constructed Fv library, an Fv antibody screened by the screening method, and an Fv library constructed by the Fv library construction method. The Fv library of the present invention is based on a combination of proteins so that members thereof can be individually analyzed for their function. Moreover, the Fv library enables a desired Fv antibody to be screened without needing a target antigen preparation. In addition, the protein combination based Fv library makes it possible to significantly reduce the number of protein purification processes to thereby reduce costs and time, compared to conventional DNA-based libraries.

Abstract: The present invention relates to a method for constructing an Fv library based on a combination of proteins, a method of screening a desired antibody using the constructed Fv library, an Fv antibody screened by the screening method, and an Fv library constructed by the Fv library construction method. The Fv library of the present invention is based on a combination of proteins so that members thereof can be individually analyzed for their function. Moreover, the Fv library enables a desired Fv antibody to be screened without needing a target antigen preparation. In addition, the protein combination based Fv library makes it possible to significantly reduce the number of protein purification processes to thereby reduce costs and time, compared to conventional DNA-based libraries.

Abstract: The present invention relates to a self-cleaving fusion protein including a target protein, a peptide consisting of amino acid sequence represented by LPXTG, a domain of Sortase A having cleaving function, and a tag, which are sequentially positioned from the amino terminal; a nucleic acid encoding the same; an expression vector including the nucleic acid of the present invention; and a cell transformed with the expression vector of the present invention. In addition, the present invention relates to a method for refining a target protein including culturing, dissolving, and purifying the transformed cell, and a method for preparing a therapeutic antibody-drug conjugate by using the purifying method.

Abstract: The present invention relates to a self-cleaving fusion protein including a target protein, a peptide consisting of amino acid sequence represented by LPXTG, a domain of Sortase A having cleaving function, and a tag, which are sequentially positioned from the amino terminal; a nucleic acid encoding the same; an expression vector including the nucleic acid of the present invention; and a cell transformed with the expression vector of the present invention. In addition, the present invention relates to a method for refining a target protein including culturing, dissolving, and purifying the transformed cell, and a method for preparing a therapeutic antibody-drug conjugate by using the purifying method.

Abstract: There is provided a pipeline inspection device including: a body part contacting a pipeline and accommodating the pipeline; a coupling part coupled to the body part to enclose the pipeline; and a sensor part including a sensor on at least one of one side of the body part and one side of the coupling part which are in contact with the pipeline to inspect an internal state of the pipeline. The pipeline inspection device according to exemplary embodiments is capable of inspecting pipelines without increasing a gap between the pipelines even in a case in which the gap therebetween is relatively narrow, and is capable of readily and rapidly inspecting a large area of pipelines.

Abstract: Methods for making a combinatorial antibody library from human germline segments are provided. Also provided are libraries of nucleic acid molecules compiled from germline segments encoding VL chains and libraries of nucleic acid molecules encoding VH chains, and resulting antibody libraries. The libraries are provided as addressable libraries. Methods for screening antibody libraries against a target protein antigen, and the identified or selected antibodies are provided.

Abstract: The present invention relates to a self-cleaving fusion protein including a target protein, a peptide consisting of amino acid sequence represented by LPXTG, a domain of Sortase A having cleaving function, and a tag, which are sequentially positioned from the amino terminal; a nucleic acid encoding the same; an expression vector including the nucleic acid of the present invention; and a cell transformed with the expression vector of the present invention. In addition, the present invention relates to a method for refining a target protein including culturing, dissolving, and purifying the transformed cell, and a method for preparing a therapeutic antibody-drug conjugate by using the purifying method.

Abstract: The present invention relates to a method for constructing an Fv library based on a combination of proteins, a method of screening a desired antibody using the constructed Fv library, an Fv antibody screened by the screening method, and an Fv library constructed by the Fv library construction method. The Fv library of the present invention is based on a combination of proteins so that members thereof can be individually analyzed for their function. Moreover, the Fv library enables a desired Fv antibody to be screened without needing a target antigen preparation. In addition, the protein combination based Fv library makes it possible to significantly reduce the number of protein purification processes to thereby reduce costs and time, compared to conventional DNA-based libraries.

Abstract: Methods for making a combinatorial antibody library from human germline segments are provided. Also provided are libraries of nucleic acid molecules compiled from germline segments encoding VL chains and libraries of nucleic acid molecules encoding VH chains, and resulting antibody libraries. The libraries are provided as addressable libraries. Methods for screening antibody libraries against a target protein antigen, and the identified or selected antibodies are provided.

Abstract: There is provided a pipeline inspection device including: a body part contacting a pipeline and accommodating the pipeline; a coupling part coupled to the body part to enclose the pipeline; and a sensor part including a sensor on at least one of one side of the body part and one side of the coupling part which are in contact with the pipeline to inspect an internal state of the pipeline. The pipeline inspection device according to exemplary embodiments is capable of inspecting pipelines without increasing a gap between the pipelines even in a case in which the gap therebetween is relatively narrow, and is capable of readily and rapidly inspecting a large area of pipelines.

Abstract: The present invention discloses an eddy current probe and an eddy current inspection device including the eddy current probe for inspection of surface defect of a rotor wheel including a dovetail coupling part in which a hook is formed. The eddy current probe in accordance with an embodiment of the present invention includes: a main body, a contact part coupled to the main body and having a convex part and a concave part formed thereon corresponding to the hook, and an eddy current sensor being coupled to an end part of the convex part of the contact part. Accordingly, the detectability of a defect and the permeation depth can be enhanced, and the inspection procedures can be simplified.

Abstract: Methods for making a combinatorial antibody library from human germline segments are provided. Also provided are libraries of nucleic acid molecules compiled from germline segments encoding VL chains and libraries of nucleic acid molecules encoding VH chains, and resulting antibody libraries. The libraries are provided as addressable libraries. Methods for screening antibody libraries against a target protein antigen, and the identified or selected antibodies are provided.

Abstract: The present invention discloses an eddy current probe and an eddy current inspection device including the eddy current probe for inspection of surface defect of a rotor wheel including a dovetail coupling part in which a hook is formed. The eddy current probe in accordance with an embodiment of the present invention includes: a main body, a contact part coupled to the main body and having a convex part and a concave part formed thereon corresponding to the hook, and an eddy current sensor being coupled to an end part of the convex part of the contact part. Accordingly, the detectability of a defect and the permeation depth can be enhanced, and the inspection procedures can be simplified.

Abstract: A charge pumping circuit is provided to regulate the amount of charge to be pumped according to a driving voltage to reduce the loss of power and increase charge pumping efficiency. The charge pumping circuit includes: a driving voltage sensing unit sensing a driving voltage to generate one or more sensing signals for determining the amount of charge to be pumped; a multi-level clock generation unit generating a pair of clock signals each having an amplitude corresponding to a signal value of each of the one or more sensing signals; and a charge pumping unit charging the pair of clock signals to generate a charged voltage, adding the charged voltage to the driving voltage, and outputting the same.

Abstract: A process for preparing As4O6 comprises successively heating and cooling a mixture of natural Sinsuk and 40% alcohol in a ratio of about 1: about 1 for about 1 to about 2 hour(s) resulting in a product, successively washing the product with distilled water thereby forming washed precipitates, maintaining the washed precipitates at about ?40° C. for 24 hours, defrosting, filtering, and drying the precipitates, and successively heating and cooling the precipitates to obtain the final As4O6 product.

Abstract: A time division duplexing (TDD) transmission/reception apparatus and method are provided. The TDD transmission/reception apparatus includes: a transmitter which generates a transmitted signal; an antenna which transmits the transmitted signal to an external device and receives a received signal from an external device; a receiver which restores source data by demodulating the received signal; and a polarized duplexer which has a first end connected to the transmitter and the receiver and a second end connected to the antenna and comprises an inclined surface, the inclined surface polarizing the transmitted signal and the received signal such that the directivity of the transmitted signal and the directivity of the received signal are perpendicular to each other.