Abstract: The present document relates to a manufacturing method for pH-sensitive graft polymer micelles and a polymer micelle-type pharmaceutical composition containing the graft copolymer. The pH-sensitive graft copolymer micelles are usable as various markers and contrast agents for various molecular images for the diagnosis and treatment of diseases and a carrier for delivery of various medicines according to disease. The pH-sensitive graft copolymer forms micelles that can be used in target-oriented diagnosis and medicine release according to changes in the pH of a body. The polymer micelles are provided by inducing a graft copolymer of poly(?-amino ester) compounds which has a solubility in water depending on pH but is incapable of forming the micelles due to a self-assembly phenomenon, and hydrophilic poly(ethylene glycol) compounds.

Abstract: Disclosed is a temperature- and pH-sensitive hydrogel composed of a poly(amidoamine) oligomer only. The hydrogel is prepared in a simple manner and is readily released from the body. Further disclosed are a method for preparing the hydrogel and a drug carrier using the hydrogel.

Abstract: A method for fabricating a semiconductor device is disclosed. The method includes forming a first oxide film, a nitride film, and a second oxide film on a semiconductor substrate in succession, etching the second oxide film and the nitride film to form a second oxide film pattern and a nitride film pattern, exposing a portion of the first oxide film, performing at least one nitrogen implantation into the semiconductor substrate to form a nitrogen injection region under the exposed portion of the first oxide film, forming a third oxide film over the second oxide film pattern, the nitride film pattern, and the semiconductor substrate, forming a trench that is deeper than the nitrogen ion injection region by etching the semiconductor substrate using the second oxide film pattern as a mask, and filling the trench with an oxide film to form a device isolating film.

Abstract: Disclosed is a pH-sensitive block copolymer that forms polyionic complex micelles. The block copolymer is prepared by copolymerization of (a) a polyethylene glycol compound, (b) a poly(amino acid) compound, and (c) a heterocyclic alkyl amine compound having the ability to induce the formation of ionic complexes. Further disclosed is a drug or protein carrier using the block copolymer.

Abstract: The manufacturing method includes etching a semiconductor substrate to form a trench, preparing a liner nitride layer over the semiconductor substrate to cover the inner side of the trench, depositing a protective oxide layer over the liner nitride layer, preparing a gap filling dielectric layer over the semiconductor substrate with the trench having the protective oxide layer deposited therein, and planarizing the gap filling dielectric layer to form a device isolation film. To prevent damage to the pad nitride layer and the inner bottom of the trench, the method further includes deposition of a protective oxide layer such as HTO film throughout a surface of the substrate as well as the inner side of the trench, thereby producing a semiconductor device with excellent quality.

Abstract: Disclosed herein are pH- and temperature-sensitive block copolymer with excellent safety and a method for preparing the same and a hydrogel and a drug carrier using the block copolymer. According to the present invention, the pH- and temperature-sensitive block copolymer comprises: obtained by copolymerization of: (a) polyethylene glycol-based compound (A); and (b) poly (?-amino ester)-based oligomer (B) or poly (amido amine)-based oligomer (C) or coupling of mixture (D) thereof. In order to control biodegradation rate, the block copolymer is mixed with poly (amido amine)-based oligomer instead of the poly (?-amino ester)-based oligomer and then coupling them.

Abstract: The present invention relates to a block copolymer formed by coupling the following components with each other, as well as a hydrogel composition comprising the block copolymer and a hydrogel formed from the composition: (a) a copolymer of a polyethylene glycol (PEG)-based compound with a biodegradable polymer; and (b) a sulfonamide-based oligomer. The inventive block copolymer shows the sol-gel transition behavior sensitive to changes in not only temperature but also pH. Thus, the inventive block copolymer overcomes the shortcomings of temperature-sensitive copolymers, form a more strong and stable hydrogel, and is stable in vivo. Accordingly, the inventive block copolymer can be used in various applications in the medical and drug delivery fields.

Abstract: A method for fabricating a semiconductor device is disclosed. The method includes forming a first oxide film, a nitride film, and a second oxide film on a semiconductor substrate in succession, etching the second oxide film and the nitride film to form a second oxide film pattern and a nitride film pattern, exposing a portion of the first oxide film, performing at least one nitrogen implantation into the semiconductor substrate to form a nitrogen injection region under the exposed portion of the first oxide film, forming a third oxide film over the second oxide film pattern, the nitride film pattern, and the semiconductor substrate, forming a trench that is deeper than the nitrogen ion injection region by etching the semiconductor substrate using the second oxide film pattern as a mask, and filling the trench with an oxide film to form a device isolating film.

Abstract: A method for manufacturing a semiconductor device includes a gate dielectric film formed over an active area of a semiconductor substrate, and a gate electrode formed over the gate dielectric film and formed of a silicidation film having a polysilicon area at the bottom of the gate electrode. Therefore, with embodiments, a work function can variously controlled and the gate pattern having different work function can be applied to the transistors by using a non-silicided polysilicon region due to the formation a partially silicided gate pattern, such that the resistance of the gate electrode and junction can be reduced, making it possible to maximize the device characteristics.

Abstract: An earthquake-resistant flat expansion joint using a hinge is provided which includes an expansion joint main body disposed between opposite ends of deck slabs of a bridge or an elevated road, hinged to one side of the deck slab at its one end to enable behavior in X, Y and Z-axis directions, and expanded or shrunk depending on temperature variation and vibrations due to earthquakes to be moved in the X, Y and Z-axis directions, an expansion/shrinkage member connected to one end of the expansion joint main body to accommodate the behavior in X, Y and Z-axis directions due to expansion and shrinkage of the expansion joint main body caused by temperature variation and occurrence of the earthquakes, a hinge shaft support member installed at one end of the deck slab to support a lower part and side parts of a hinge shaft part of the expansion joint main body, an expansion joint support member installed at one end of the other deck slab to support lower parts of an expansion part of the expansion joint main body a

Abstract: An emergency guidance lamp system for guiding to the nearest exit in the event of a fire is provided. A fire detection sensor is installed at a specific region such as ceilings or passages of tunnels or large buildings, and detects a fire occurrence and sends a corresponding detection signal. A central control unit receives the detection signal from the fire detection sensor, judges a situation on the fire occurrence based on simulation result data of various numbers of cases of fire occurrence that have been previously performed and stored in an internal memory, and sends red and green lighting control signals most suitable for each guidance lamp apparatus installed at the site. A guidance lamp apparatus is installed on the ceiling, wall surface, or bottom surface of a passage or the like of tunnels or large buildings, and has a red lighting unit and a green lighting unit provided at the body thereof.

Abstract: A semiconductor device and a method for manufacturing the same that includes forming a gate insulating film on a semiconductor substrate; and then forming a doped polysilicon layer on the gate insulating film; and then forming a first metal layer on the doped polysilicon layer; and then forming a metal silicide layer on the first metal layer. Therefore, current leakage can be reduced and generation of boron penetration can be prevented. Forming the doped polysilicon layer on the gate insulating film enables control of a work function while forming a silicide layer having a uniform surface interface is possible by depositing nickel (Ni) and polysilicon on the platinum first metal layer.

Abstract: Disclosed is a block copolymer formed by coupling the following components with each other: (a) a copolymer (A) of a polyethylene glycol (PEG) type compound with a biodegradable polymer; and (b) at least one oligomer (B) selected from the group consisting of poly(?-amino ester) and poly(amido amine). A method for preparing the same block copolymer, and a polymeric hydrogel type drug composition comprising the temperature and pH-sensitive block copolymer and a physiologically active substance that can be encapsulated with the block copolymer are also disclosed. The multiblock copolymer is obtained by copolymerization of a pH-sensitive poly(?-amino ester) and/or poly(amido amine) type oligomer, a hydrophilic and temperature-sensitive polyethylene glycol type compound and a hydrophobic and biodegradable polymer.

Abstract: A method of installing or exchanging a rubber seal for an expansion joint is provided, which includes installing guide rails for detachably mounting the rubber seal on both vertical parts of lower plates, installing a plurality of guide rollers at both ends of the rubber seal in a longitudinal direction thereof using guide roller fixing members to slidably fix the rubber seal to the guide rails, suspending wires from a lower one side of the expansion joint to an opposite side thereof to a sufficient length to pull the rubber seal, fastening one end of the wire to a wire hole of the guide roller fixing member coupled to the rubber seal from a start point of pushing the rubber seal, inserting a portion of the guide roller fastened to the wire into one start point of the guide rail and pulling the wire from the other termination point of the guide rail, and after inserting the rubber seal, cutting the rubber seal to the length between both ends of the guide rail or the length of the expansion joint and fixing th

Abstract: Disclosed herein is a temperature- and pH-sensitive block copolymer having excellent gel strength, including: (a) a poly(ethylene glycol)-based compound (A) or a copolymer (B) of the poly(ethylene glycol)-based compound (A) and a biodegradable polymer; and (b) a polyurethane-based oligomer (C). Further, a method of preparing a temperature and pH-sensitive block copolymer having excellent gel strength, including: (a) synthesizing a poly(ethylene glycol)-based compound (A) or a copolymer (B) of the poly(ethylene glycol)-based compound (A) and a biodegradable polymer; and (b) coupling a polyurethane-based oligomer (C) with the copolymer (B), is disclosed. Also disclosed is a polymer hydrogel type drug delivery system, including: (a) the block copolymer; and (b) a physiologically active substance which can be included in the block copolymer.

Abstract: Disclosed is a method for manufacturing a semiconductor device. The method includes the steps of forming an insulating layer on a substrate, partially exposing the substrate by selectively etching the insulating layer, implanting ions into the exposed substrate using the etched insulating layer as an ion implantation mask, and removing the etched insulating layer from the ion-implanted substrate.

Abstract: Disclosed is a pH-sensitive block copolymer obtained by copolymerization of: (a) a polyethylene glycol compound (A); and (b) at least one poly(amino acid) compound selected from the group consisting of a poly(?-amino ester) and poly(amido amine) or a copolymer thereof (B). A method for preparing the same block copolymer, and a polymer micelle type drug composition comprising the pH-sensitive block copolymer and a physiologically active substance that can be encapsulated with the block copolymer are also disclosed. The pH-sensitive block copolymer is obtained by polymerization of a hydrophilic polyethylene glycol compound with a pH-sensitive biodegradable poly(amino acid) compound. Therefore, the pH-sensitive block copolymer can form a micelle structure due to its amphiphilicity and ionization characteristics depending on pH variations, and thus can be used as drug carrier for target-directed drug delivery depending on pH variations in the body.