Abstract: The present invention relates to a method for preparing biodegradable microspheres using a single-phase mixed solution containing water, alcohol, and dichloromethane. Provided is a method for preparing a biodegradable microsphere having a uniform drug loading efficiency by preparing and using a single-phase mixed solution in which no phase separation occurs without using a thickener and a surfactant. The preparation method of the present invention has the feature of keeping the content of a loaded drug uniform until a final biodegradable microsphere is prepared, by using a single-phase mixed solution in which no phase separation by a solvent occurs in the preparation process. Thus, the preparation method of the present invention is remarkably useful for the preparation of biodegradable microspheres.

Abstract: The present disclosure relates to a method for preparing biocompatible polymer-based Apixaban-loaded microspheres. More specifically, the present disclosure relates to a method for preparing biocompatible polymer-based Apixaban-loaded microspheres, where the method includes: i) adding a fatty acid or triglyceride to a dispersed phase; and ii) preparing microspheres using a microfluidic method. The method for preparing biocompatible polymer-based Apixaban-loaded microspheres of the present disclosure may be effectively used in the preparation of microspheres in which Apixaban is stably encapsulated in high contents.

Abstract: The present disclosure relates to a composition of dispersed phase for the preparation of Apixaban-loaded microspheres and biocompatible polymer-based Apixaban-loaded microspheres prepared therefrom. Specifically, the present disclosure relates to a composition of dispersed phase for the preparation of Apixaban-loaded microspheres, where the composition includes i) Apixaban or a pharmaceutically acceptable salt thereof; ii) a biocompatible polymer; iii) a fatty acid or triglyceride; and iv) a halogen organic solvent; and biocompatible polymer-based Apixaban-loaded microspheres. The composition of dispersed phase for the preparation of Apixaban-loaded microspheres shows excellent stability and thus may be useful for the preparation of Apixaban-loaded microspheres.

Abstract: The present invention relates to a method for preparing biodegradable microspheres using a single-phase mixed solution containing water, alcohol, and dichloromethane. Provided is a method for preparing a biodegradable microsphere having a uniform drug loading efficiency by preparing and using a single-phase mixed solution in which no phase separation occurs without using a thickener and a surfactant. The preparation method of the present invention has the feature of keeping the content of a loaded drug uniform until a final biodegradable microsphere is prepared, by using a single-phase mixed solution in which no phase separation by a solvent occurs in the preparation process. Thus, the preparation method of the present invention is remarkably useful for the preparation of biodegradable microspheres.