Patents by Inventor Dora Graciela Tombari

Dora Graciela Tombari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline form of the zoledronic acid, a process to obtain it and the pharmaceutical composition comprising it
    Patent number: 8952172
    Abstract: A new crystalline form of the Zoledronic acid, characterized by its X-rays diffractogram as well as by its spatial atomic distribution in the red crystalline and its curves of thermal analysis. There is also included a method to obtain this crystalline form, which includes the synthesis of the corresponding acid and the pharmaceutical composition this crystalline form comprises.
    Type: Grant
    Filed: February 4, 2010
    Date of Patent: February 10, 2015
    Assignee: Gador S.A.
    Inventors: Rafael Alberto Labriola, Dora Graciela Tombari, Adriana Vechhioli
  • Crystalline form of the zoledronic acid, a process to obtain it and the pharmaceutical composition comprising it
    Patent number: 8338619
    Abstract: A method to obtain a new crystalline form of the Zoledronic acid, characterized by its X-rays diffractogram as well as by its spatial atomic distribution in the red crystalline and its curves of thermal analysis. There is also included a method to obtain this crystalline form, which includes the synthesis of the corresponding acid and the pharmaceutical composition this crystalline form comprises.
    Type: Grant
    Filed: February 4, 2010
    Date of Patent: December 25, 2012
    Assignee: Gador S.A.
    Inventors: Rafael Alberto Labriola, Dora Graciela Tombari, Adriana Vechhioli
  • Solid and crystalline dutasteride and processes for preparation thereof
    Patent number: 8153648
    Abstract: The solid state chemistry of 17?-N-[2,5-bis(trifluoromethyl)phenyl]carbamoyl-4-aza-5-?-androst-1-en-3-one of which the international nonproprietary name is Dutasteride (the active ingredient in products marketed as Avodart, Avidart, Avolve, Duagen, Dutas, Dutagen, Duprost) and its process for preparing. The synthetic process comprises formation of the mixed anhydride, its subsequent reaction with 2,5-bis(trifluoromethyl)phenylamine in the presence of an appropriate Lewis catalyst and its isolation, purification and crystallization from acetonitrile/water.
    Type: Grant
    Filed: January 3, 2009
    Date of Patent: April 10, 2012
    Assignee: Gador S.A.
    Inventors: Dora Graciela Tombari, Constanza Pia Mangone, Maria Beatriz Garcia, Adriana Vechhioli, Rafael Alberto Labriola
  • CRYSTALLINE FORM OF THE ZOLEDRONIC ACID, A PROCESS TO OBTAIN IT AND THE PHARMACEUTICAL COMPOSITION COMPRISING IT
    Publication number: 20100197931
    Abstract: A new crystalline form of the Zoledronic acid, characterized by its X-rays diffractogram as well as by its spatial atomic distribution in the red crystalline and its curves of thermal analysis. There is also included a method to obtain this crystalline form, which includes the synthesis of the corresponding acid and the pharmaceutical composition this crystalline form comprises.
    Type: Application
    Filed: February 4, 2010
    Publication date: August 5, 2010
    Applicant: Gador S.A.
    Inventors: Rafael Alberto Labriola, Dora Graciela Tombari, Adriana Vechhioli
  • SOLID AND CRYSTALLINE DUTASTERIDE AND PROCESSES FOR PREPARATION THEREOF
    Publication number: 20090203724
    Abstract: The solid state chemistry of 17?-N-[2,5-bis(trifluoromethyl)phenyl]carbamoyl-4-aza-5-?-androst-1-en-3-one of which the international nonproprietary name is Dutasteride (the active ingredient in products marketed as Avodart, Avidart, Avolve, Duagen, Dutas, Dutagen, Duprost) and its process for preparing. The synthetic process comprises formation of the mixed anhydride, its subsequent reaction with 2,5-bis(trifluoromethyl)phenylamine in the presence of an appropriate Lewis catalyst and its isolation, purification and crystallization from acetonitrile/water.
    Type: Application
    Filed: January 3, 2009
    Publication date: August 13, 2009
    Applicant: GADOR S.A.
    Inventors: Dora Graciela Tombari, Constanza Pia Mangone, Maria Beatriz Garcia, Adriana Vecchioli, Rafael Alberto Labriola
  • Process for obtaining norelgestromin in different relations of isomers E and Z
    Patent number: 7345183
    Abstract: The present invention is related to an oxime of the 13?-ethyl-17?-hydroxi-18,19-dinorpregn-4-en-20-in-3-o (norelgestromin) of Formula I with a relation of isomers E/Z between 1.3 and 1.6 and the method of producing the oxime.
    Type: Grant
    Filed: June 25, 2004
    Date of Patent: March 18, 2008
    Assignee: Gador S.A.
    Inventors: Dora Graciela Tombari, Adriana Vecchioli
  • Process for obtaining norelgestromin in different relations of isomers E and Z
    Publication number: 20040266741
    Abstract: The present invention is related to an oxime of the 13&bgr;-ethyl-17&agr;-hydroxi-18,19-dinorpregn-4-en-20-in-3-o (norelgestromin) of Formula I with a relation of isomers E/Z between 1.3 and 1.
    Type: Application
    Filed: June 25, 2004
    Publication date: December 30, 2004
    Inventors: Dora Graciela Tombari, Adriana Vecchioli