Patents by Inventor Dorian Liepmann
Dorian Liepmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240108869Abstract: Provided are active agent delivery devices configured to deliver an active agent formulation into or through a mucosal layer in a subject. The active agent delivery devices include a power reservoir configured to eject the active agent formulation at a pressure sufficient to deliver the active agent formulation into or through a mucosal layer in a subject. Methods of using the subject active agent delivery devices are also provided.Type: ApplicationFiled: November 30, 2023Publication date: April 4, 2024Inventors: Kiana Aran, Jacobo Paredes, Niren Murthy, Dorian Liepmann, Kunwoo Lee
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Patent number: 11865286Abstract: Provided are active agent delivery devices configured to deliver an active agent formulation into or through a mucosal layer in a subject. The active agent delivery devices include a power reservoir configured to eject the active agent formulation at a pressure sufficient to deliver the active agent formulation into or through a mucosal layer in a subject. Methods of using the subject active agent delivery devices are also provided.Type: GrantFiled: June 23, 2020Date of Patent: January 9, 2024Assignee: The Regents of the University of CaliforniaInventors: Kiana Aran, Jacobo Paredes, Niren Murthy, Dorian Liepmann, Kunwoo Lee
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Publication number: 20200316352Abstract: Provided are active agent delivery devices configured to deliver an active agent formulation into or through a mucosal layer in a subject. The active agent delivery devices include a power reservoir configured to eject the active agent formulation at a pressure sufficient to deliver the active agent formulation into or through a mucosal layer in a subject. Methods of using the subject active agent delivery devices are also provided.Type: ApplicationFiled: June 23, 2020Publication date: October 8, 2020Inventors: Kiana Aran, Jacobo Paredes, Niren Murthy, Dorian Liepmann, Kunwoo Lee
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Patent number: 10729895Abstract: Provided are active agent delivery devices configured to deliver an active agent formulation into or through a mucosal layer in a subject. The active agent delivery devices include a power reservoir configured to eject the active agent formulation at a pressure sufficient to deliver the active agent formulation into or through a mucosal layer in a subject. Methods of using the subject active agent delivery devices are also provided.Type: GrantFiled: September 29, 2015Date of Patent: August 4, 2020Assignee: The Regents of the University of CaliforniaInventors: Kiana Aran, Jacobo Paredes, Niren Murthy, Dorian Liepmann, Kunwoo Lee
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Publication number: 20180071730Abstract: Some configurations of a microfluidic apparatus can comprise a fluidic circuit of interconnected fluidic structures into which a plurality of different media can be introduced or extracted. A variety of operations can be performed with the different media including isolating with a second medium one or more of the fluidic structures that is filled partially or fully with a first medium. Discrete volumes of a medium can be moved through the isolating second medium to deliver materials or micro-objects to or remove micro-objects or materials from a fluidic structure that is otherwise isolated by the second medium. Some configurations of a microfluidic apparatuses can isolate microfluidic structures in a microfluidic apparatus using flow rates or blocking structures, and some configurations can manage bubbles in fluidic structures.Type: ApplicationFiled: June 27, 2017Publication date: March 15, 2018Inventors: Keith Joseph Breinlinger, Eric D. Hobbs, Dorian Liepmann, Joshua Tanner Nevill, Mark P. White, Maria Jimena Loureiro
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Publication number: 20170246438Abstract: Provided are active agent delivery devices configured to deliver an active agent formulation into or through a mucosal layer in a subject. The active agent delivery devices include a power reservoir configured to eject the active agent formulation at a pressure sufficient to deliver the active agent formulation into or through a mucosal layer in a subject. Methods of using the subject active agent delivery devices are also provided.Type: ApplicationFiled: September 29, 2015Publication date: August 31, 2017Inventors: Kiana Aran, Jacobo Paredes, Niren Murthy, Dorian Liepmann, Kunwoo Lee
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Publication number: 20160166185Abstract: Provided is a blood analyte collection device that includes a microneedle array configured to provide fluid communication between a cellular interstitial fluid of a subject and a collection device fluid, a device chamber containing the collection device fluid, and a sequestration material in the device chamber configured to bind to a blood analyte from the cellular interstitial fluid. Also provided are methods and kits that use the subject blood analyte collection device. The subject devices, methods and kits find use in a variety of applications, such as detecting a blood analyte, such as glucose, in a subject.Type: ApplicationFiled: August 21, 2014Publication date: June 16, 2016Inventors: Dorian Liepmann, Jacobo Paredes, Gerard Marriott
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Publication number: 20150352547Abstract: Some configurations of a microfluidic apparatus can comprise a fluidic circuit of interconnected fluidic structures into which a plurality of different media can be introduced or extracted. A variety of operations can be performed with the different media including isolating with a second medium one or more of the fluidic structures that is filled partially or fully with a first medium. Discrete volumes of a medium can be moved through the isolating second medium to deliver materials or micro-objects to or remove micro-objects or materials from a fluidic structure that is otherwise isolated by the second medium. Some configurations of a microfluidic apparatuses can isolate microfluidic structures in a microfluidic apparatus using flow rates or blocking structures, and some configurations can manage bubbles in fluidic structures.Type: ApplicationFiled: June 6, 2015Publication date: December 10, 2015Applicant: Berkeley Lights, Inc.Inventors: Keith Joseph Breinlinger, Eric D. Hobbs, Dorian Liepmann, Joshua Tanner Nevill, Mark P. White, Maria Jimena Loureiro
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Publication number: 20110105871Abstract: A method and apparatus for substance monitoring. One application is an easy to handle continuous glucose monitor using a group of hollow out-of-plane silicon microneedles to sample substances in interstitial fluid from the epidermal skin layer. The glucose of the interstitial fluid permeates a dialysis membrane and reaches a sensor. Using MEMS technology, for example, allows well-established batch fabrication at low cost.Type: ApplicationFiled: August 4, 2010Publication date: May 5, 2011Inventors: Stefan Zimmermann, Boris Stoeber, Dorian Liepmann, Albert Pisano
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Publication number: 20090306454Abstract: Devices, systems and methods are provided for directly stimulating tissues, particularly muscle tissues, to modulate muscle contractions (i.e. provide reanimation of the muscle or to suppress undesired muscle contractions). Reanimation of muscles may be desired when damage to the brain, nervous system or neuromuscular junctions have occurred, causing a muscle tissue to lack sufficient motor control. Suppression of muscle contractions may be desired in situations of pathologically hyperactive muscles, such as in conditions of muscle spasm (e.g. blepharospasm and hemifacial spasm) or muscle dystonia. Direct stimulation is achieved by delivering a chemical agent directly to the muscle tissue, particularly the motor end plate, bypassing the nerves and neuromuscular junctions which may be damaged or diseased. Implanted hybrid chemical and electromagnetic stimulation devices can modulate muscle contraction in response to signals from a controller.Type: ApplicationFiled: May 3, 2006Publication date: December 10, 2009Applicant: Stanford UniversityInventors: Kimberly P. Cockerham, Harvey A. Fishman, Anthony Liu, Alissa M. Fitzgeral, Dorian Liepmann, Benjamin W. Chul, Michael F. Marmor, Wentai Liu, Juan G. Santiago
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Publication number: 20090069651Abstract: A method and apparatus for substance monitoring. One application is an easy to handle continuous glucose monitor using a group of hollow out-of-plane silicon microneedles to sample substances in interstitial fluid from the epidermal skin layer. The glucose of the interstitial fluid permeates a dialysis membrane and reaches a sensor. Using MEMS technology, for example, allows well-established batch fabrication at low cost.Type: ApplicationFiled: August 8, 2008Publication date: March 12, 2009Inventors: Stefan Zimmermann, Boris Stoeber, Dorian Liepmann, Albert Pisano
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Patent number: 7415299Abstract: A method and apparatus for substance monitoring. One application is an easy to handle continuous glucose monitor using a group of hollow out-of-plane silicon microneedles to sample substances in interstitial fluid from the epidermal skin layer. The glucose of the interstitial fluid permeates a dialysis membrane and reaches a sensor. Using MEMS technology, for example, allows well-established batch fabrication at low cost.Type: GrantFiled: April 19, 2004Date of Patent: August 19, 2008Assignee: The Regents of the University of CaliforniaInventors: Stefan Zimmermann, Boris Stoeber, Dorian Liepmann, Albert Pisano
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Publication number: 20060211933Abstract: A method and apparatus for substance monitoring. One application is an easy to handle continuous glucose monitor using a group of hollow out-of-plane silicon microneedles to sample substances in interstitial fluid from the epidermal skin layer. The glucose of the interstitial fluid permeates a dialysis membrane and reaches a sensor. Using MEMS technology, for example, allows well-established batch fabrication at low cost.Type: ApplicationFiled: April 19, 2004Publication date: September 21, 2006Inventors: Stefan Zimmermann, Boris Stoeber, Dorian Liepmann, Albert Pisano
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Publication number: 20060025717Abstract: A method and apparatus for forming microneedles and other microstructures using hardenable materials and useful for substance monitoring and/or drug delivery.Type: ApplicationFiled: April 27, 2005Publication date: February 2, 2006Inventors: Stefan Zimmermann, Boris Stoeber, Dorian Liepmann, Albert Pisano
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Patent number: 6976527Abstract: A microcapillary pumped loop (CPL) for chip level temperature control includes two mating substrates which define an evaporator, a condenser, and a reservoir for a liquid. A first substrate includes a vapor line which couples vapor from the evaporator to the condenser, and a liquid line which couples liquid from the condenser back to the evaporator. A wicking structure for the evaporator is formed by etching in the second substrate. The wicking structure couples the evaporator to the reservoir and to the liquid line. The condenser includes a plurality of grooves formed in the second substrate which couples liquid from the condenser to the liquid line.Type: GrantFiled: July 16, 2002Date of Patent: December 20, 2005Assignee: The Regents of the University of CaliforniaInventors: Jeffrey Kirshberg, Kirk L. Yerkes, Dorian Liepmann
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Publication number: 20030162181Abstract: A method for single molecule identification of a target DNA molecule in a random coil state having the following steps: a) attaching an optically distinguishable material to a DNA sequence recognition unit; b) hybridizing the DNA sequence recognition unit to the target DNA molecule in a random coil state to form a hybridized DNA complex in a random coil state; c) passing the hybridized DNA complex in a random coil state from a reservoir in a microfluidic device through a narrow channel to cause an acceleration of flow through the channel, thereby causing the hybridized DNA complex to extend into a substantially linear configuration; and d) detecting the optically distinguishable material in a sequential manner along the substantially linear hybridized DNA complex, thereby identifying the target DNA molecule.Type: ApplicationFiled: February 28, 2002Publication date: August 28, 2003Applicant: Eastman Kodak CompanyInventors: Zhihao Yang, Tiecheng A. Qiao, Susan J. Muller, Dorian Liepmann
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Publication number: 20030066625Abstract: A microcapillary pumped loop (CPL) for chip level temperature control includes two mating substrates which define an evaporator, a condenser, and a reservoir for a liquid. A first substrate includes a vapor line which couples vapor from the evaporator to the condenser, and a liquid line which couples liquid from the condenser back to the evaporator. A wicking structure for the evaporator is formed by etching in the second substrate. The wicking structure couples the evaporator to the reservoir and to the liquid line. The condenser includes a plurality of grooves formed in the second substrate which couples liquid from the condenser to the liquid line.Type: ApplicationFiled: July 16, 2002Publication date: April 10, 2003Applicant: The Regents of the University of CaliforniaInventors: Jeffrey Kirshberg, Kirk L. Yerkes, Dorian Liepmann
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Patent number: 6520197Abstract: A micro-electromechanical system and method for continuous laminar fluid mixing. An embodiment of the invention described in the specification includes a mixing channel, a first delivery channel that is connected to the mixing channel, and a second delivery channel that is connected to the mixing channel. A first pump mechanism produces pulses in the first delivery channel. A second pump mechanism produces pulses in the second delivery channel. The first pulsed fluid stream and the second pulsed fluid stream merge in the mixing channel to form a mixed fluid. The pulses in the fluids operate to distort the interface between the fluids to facilitate diffusion between the fluids.Type: GrantFiled: May 30, 2001Date of Patent: February 18, 2003Assignee: The Regents of the University of CaliforniaInventors: Ajay Deshmukh, Dorian Liepmann
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Patent number: 6406638Abstract: A method of forming a needle includes the step of anisotropically etching a channel into the back side of a semiconductor substrate. The front side of the semiconductor substrate is then isotropically etched to form a vertical axial surface surrounding the channel. The resultant needle has an elongated body formed of a semiconductor material. The elongated body includes an axial surface positioned between a first end and a second end. The axial surface defines a channel between the first end and the second end. In one embodiment, the first end has a sloping tip with a single circumferential termination point.Type: GrantFiled: January 6, 2000Date of Patent: June 18, 2002Assignee: The Regents of the University of CaliforniaInventors: Boris Stoeber, Dorian Liepmann
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Publication number: 20010055242Abstract: A micro-electromechanical system and method for continuous laminar fluid mixing. An embodiment of the invention described in the specification includes a mixing channel, a first delivery channel that is connected to the mixing channel, and a second delivery channel that is connected to the mixing channel. A first pump mechanism produces pulses in the first delivery channel. A second pump mechanism produces pulses in the second delivery channel. The first pulsed fluid stream and the second pulsed fluid stream merge in the mixing channel to form a mixed fluid. The pulses in the fluids operate to distort the interface between the fluids to facilitate diffusion between the fluids.Type: ApplicationFiled: May 30, 2001Publication date: December 27, 2001Inventors: Ajay Deshmukh, Dorian Liepmann