Patents by Inventor Doris C. O'Toole

Doris C. O'Toole has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline forms of the di-sodium salt of N-(5-chlorosalicyloyl)-8-aminocaprylic acid
    Patent number: 9238074
    Abstract: The present invention relates to crystalline polymorphic forms of the di-sodium salt of N-(5-chlorosalicyloyl)-8-aminocaprylic acid, pharmaceutical compositions containing the same, methods of preparing the same, and methods for facilitating the delivery of active agents with the same.
    Type: Grant
    Filed: April 5, 2013
    Date of Patent: January 19, 2016
    Assignee: EMISPHERE TECHNOLOGIES, INC.
    Inventors: Nikhil Dhoot, Steven Dinh, Shingai Majuru, William Elliott Bay, JoAnne P. Corvino, Doris C. O'Toole
  • CRYSTALLINE FORMS OF THE DI-SODIUM SALT OF N-(5-CHLOROSALICYLOYL)-8-AMINOCAPRYLIC ACID
    Publication number: 20130303444
    Abstract: The present invention relates to crystalline polymorphic forms of the di-sodium salt of N-(5-chlorosalicyloyl)-8-aminocaprylic acid, pharmaceutical compositions containing the same, methods of preparing the same, and methods for facilitating the delivery of active agents with the same.
    Type: Application
    Filed: April 5, 2013
    Publication date: November 14, 2013
    Applicant: Emisphere Technologies, Inc.
    Inventors: Nikhil DHOOT, Steven DINH, Shingai MAJURU, William Elliott BAY, JoAnne P. CORVINO, Doris C. O'TOOLE
  • Crystalline forms of the di-sodium salt of N-(5-chlorosalicyloyl)-8-aminocaprylic acid
    Patent number: 8431736
    Abstract: The present invention relates to crystalline polymorphic forms of the di-sodium salt of N-(5-chlorosalicyloyl)-8-aminocaprylic acid, pharmaceutical compositions containing the same, methods of preparing the same, and methods for facilitating the delivery of active agents with the same.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: April 30, 2013
    Assignee: Emisphere Technologies, Inc.
    Inventors: Nikhil Dhoot, Steven Dinh, Shingai Majuru, William Elliott Bay, JoAnne P. Corvino, Doris C. O'Toole
  • CRYSTALLINE FORMS OF THE DI-SODIUM SALT OF N-(5-CHLOROSALICYLOYL)-8-AMINOCAPRYLIC ACID
    Publication number: 20120065128
    Abstract: The present invention relates to crystalline polymorphic forms of the di-sodium salt of N-(5-chlorosalicyloyl)-8-aminocaprylic acid, pharmaceutical compositions containing the same, methods of preparing the same, and methods for facilitating the delivery of active agents with the same.
    Type: Application
    Filed: August 11, 2011
    Publication date: March 15, 2012
    Applicant: Emisphere Technologies, Inc.
    Inventors: Nikhil DHOOT, Steven Dinh, Shingai Majuru, William Elliott Bay, JoAnne P. Corvino, Doris C. O'Toole
  • Crystalline forms of the di-sodium salt of N-(5-Chlorosalicyloyl)-8-aminocaprylic acid
    Patent number: 8026392
    Abstract: The present invention relates to crystalline polymorphic forms of the di-sodium salt of N-(5-chlorosalicyloyl)-8-aminocaprylic acid, pharmaceutical compositions containing the same, methods of preparing the same, and methods for facilitating the delivery of active agents with the same.
    Type: Grant
    Filed: September 18, 2006
    Date of Patent: September 27, 2011
    Assignee: Emisphere Technologies, Inc.
    Inventors: Nikhil Dhoot, Steven Dinh, Shingai Majuru, William Elliott Bay, JoAnne P. Corvino, Doris C. O'Toole
  • Compounds and compositions for delivering active agents
    Patent number: 7977506
    Abstract: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: November 8, 2006
    Date of Patent: July 12, 2011
    Assignee: Emisphere Technologies, Inc.
    Inventors: Maria Aurora P. Boyd, Andrea Leone-Bay, Doris C. O'Toole
  • Crystalline forms of the Di-Sodium Salt of N-(5-Chlorosalicyloyl)-8-Aminocaprylic Acid
    Publication number: 20080269108
    Abstract: The present invention relates to crystalline polymorphic forms of the di-sodium salt of N-(5-chlorosalicyloyl)-8-aminocaprylic acid, pharmaceutical compositions containing the same, methods of preparing the same, and methods for facilitating the delivery of active agents with the same.
    Type: Application
    Filed: September 18, 2006
    Publication date: October 30, 2008
    Applicant: EMISPHERE TECHNOLOGIES, INC.
    Inventors: Nikhil Dhoot, Steven Dinh, Shingai Majuru, William Elliott Bay, JoAnne P. Corvino, Doris C. O'Toole
  • Method of preparing alkylated salicylamides via a dicarboxylate intermediate
    Patent number: 7169776
    Abstract: The present invention relates to a method of preparing an alkylated salicylamide from a protected and activated salicylamide via a dicarboxylated salicylamide intermediate. The present invention also relates to dicarboxylic salicylamide delivery agent compounds for the delivery of active agents. Methods of administration are provided as well.
    Type: Grant
    Filed: January 19, 2005
    Date of Patent: January 30, 2007
    Assignee: Emisphere Technologies, Inc.
    Inventors: Joseph N. Bernadino, Doris C. O'Toole, William E. Bay
  • Compounds and compositions for delivering active agents
    Patent number: 7151191
    Abstract: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: January 12, 2001
    Date of Patent: December 19, 2006
    Assignee: Emisphere Technologies, Inc.
    Inventors: Maria Aurora P. Boyd, Andrea Leone-Bay, Doris C. O'Toole
  • Method of preparing alkylated salicylamides via a dicarboxylate intermediate
    Patent number: 6900344
    Abstract: The present invention relates to a method of preparing an alkylated salicylamide from a protected and activated salicylamide via a dicarboxylated salicylamide intermediate. The present invention also relates to dicarboxylic salicylamide delivery agent compounds for the delivery of active agents. Methods of administration are provided as well.
    Type: Grant
    Filed: March 21, 2001
    Date of Patent: May 31, 2005
    Assignee: Emisphere Technologies, Inc.
    Inventors: Joseph N. Bernadino, Doris C. O'Toole, William E. Bay
  • Compounds and compositions for delivering active agents
    Patent number: 6693208
    Abstract: Amino acid derivative as carrier compounds and compositions which are useful in the delivery of active agents are provided. The active agents can be a peptide, mucopolysaccharide, carbohydrate, or lipid. Methods of administration, including oral administration, and preparation are provided as well.
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: February 17, 2004
    Assignee: Emisphere Technologies, Inc.
    Inventors: David Gscheidner, Andrea Leone-Bay, Eric Wang, John J. Freeman, Doris C. O'Toole, Lynn Shields
  • Compounds and compositions for delivering active agents
    Publication number: 20030216589
    Abstract: Amino acid derivative as carrier compounds and compositions which are useful in the delivery of active agents are provided. The active agents can be a peptide, mucopolysaccharide, carbohydrate, or lipid. Methods of administration, including oral administration, and preparation are provided as well.
    Type: Application
    Filed: July 15, 2002
    Publication date: November 20, 2003
    Inventors: David Gschneidner, Andrea Leone-Bay, Eric Wang, John J. Freeman, Doris C. O'Toole, Lynn Shields
  • Compounds and compositions for delivering active agents
    Publication number: 20030149296
    Abstract: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: August 5, 2002
    Publication date: August 7, 2003
    Inventors: Maria Aurora P. Boyd, Andrea Leone-Bay, Doris C. O'Toole
  • Method of preparing alkylated salicylamides via a dicarboxylate intermediate
    Publication number: 20030096992
    Abstract: The present invention relates to a method of preparing an alkylated salicylamide from a protected and activated salicylamide via a dicarboxylated salicylamide intermediate. The present invention also relates to dicarboxylic salicylamide delivery agent compounds for the delivery of active agents. Methods of administration are provided as well.
    Type: Application
    Filed: September 20, 2002
    Publication date: May 22, 2003
    Inventors: Joseph N. Bernadino, Doris C. O'Toole, William E. Bay
  • Aminoresin based coatings containing 1,3,5-triazine tris-carbamate co-crosslinkers
    Patent number: 5726254
    Abstract: An acid cured coating composition containing a hydroxyfunctional acrylic or polyester resin and a 1,3,5-triazine-2,4,6-tris-carbamate. Also provided is an acid cured coating composition containing a hydroxyfunctional acrylic or polyester resin, a crosslinking agent such as a melamine-formaldehyde or a related aminoresin, and a co-crosslinking agent derived from a triazine tris-carbamate such as 2,4,6-tris-(butoxycarbonylamino)-1,3,5-triazine. Also provided is an improved method of coating using the above coating compositions. The coating compositions described in this invention have lower cure temperatures, lower formaldehyde emissions during cure, and produce films and objects which have superior environmental etch resistance than the conventional melamine-formaldehyde coatings which do not have a triazine tris-carbamate co-crosslinker.
    Type: Grant
    Filed: January 8, 1997
    Date of Patent: March 10, 1998
    Assignee: Cytec Technology Corp.
    Inventors: Kuang-Jong Wu, Doris C. O'Toole
  • Aminoresin based coatings containing 1,3,5-triazine tris-carbamate co-crosslinkers
    Patent number: 5593735
    Abstract: An acid cured coating composition containing a hydroxyfunctional acrylic or polyester resin and a 1,3,5-triazine-2,4,6-tris-carbamate. Also provided is an acid cured coating composition containing a hydroxyfunctional acrylic or polyester resin, a crosslinking agent such as a melamine-formaldehyde or a related aminoresin, and a co-crosslinking agent derived from a triazine tris-carbamate such as 2,4,6-tris-(butoxycarbonylamino)-1,3,5-triazine. Also provided is an improved method of coating using the above coating compositions. The coating compositions described in this invention have lower cure temperatures, lower formaldehyde emissions during cure, and produce films and objects which have superior environmental etch resistance than the conventional melamine-formaldehyde coatings which do not have a triazine tris-carbamate co-crosslinker.
    Type: Grant
    Filed: May 8, 1995
    Date of Patent: January 14, 1997
    Assignee: Cytec Technology Corp.
    Inventors: Kuang-Jong Wu, Doris C. O'Toole
  • Aminoresin based coatings containing 1,3,5-triazine tris-carbamate co-crosslinkers
    Patent number: 5574103
    Abstract: An acid cured coating composition containing a hydroxyfunctional acrylic or polyester resin and a 1,3,5-triazine-2,4,6-tris-carbamate. Also provided is an acid cured coating composition containing a hydroxyfunctional acrylic or polyester resin, a crosslinking agent such as a melamine-formaldehyde or a related aminoresin, and a co-crosslinking agent derived from a triazine tris-carbamate such as 2,4,6-tris-(butoxycarbonylamino)-1,3,5-triazine. Also provided is an improved method of coating using the above coating compositions. The coating compositions described in this invention have lower cure temperatures, lower formaldehyde emissions during cure, and produce films and objects which have superior environmental etch resistance than the conventional melamine-formaldehyde coatings which do not have a triazine tris-carbamate co-crosslinker.
    Type: Grant
    Filed: December 29, 1992
    Date of Patent: November 12, 1996
    Assignee: Cytec Technology Corp.
    Inventors: Kuang-Jong Wu, Doris C. O'Toole