Patents by Inventor Doris Mangiaracina Benbrook

Doris Mangiaracina Benbrook has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINATION CANCER THERAPIES
    Publication number: 20230346743
    Abstract: Drug combinations of a heteroarotinoid (e.g., SHetA2, SHetA3, SHetA4, SHetC2, SHetD3, SHetD4, SHetD5, SHet50, SHet65, SHet100, OHet72, NHet17, NHet86, or NHet90), and an Azabicyclooctan-3-one derivative (e.g., PRIMA-1 or PRIMAMET) and/or a CDK4/6 inhibitor (e.g., Palbociclib, Abemaciclib, Ribociclib, Narazaciclib (ON123300), Dalpiciclib, Dinaciclib, Milciclib, Seliciclib), which are effective as anti-cancer treatments, and kits and methods of use of such drug combinations.
    Type: Application
    Filed: January 26, 2023
    Publication date: November 2, 2023
    Inventors: Doris Mangiaracina Benbrook, Satish Kumar Ramraj
  • NANOCRYSTAL MICROPARTICLES OF POORLY SOLUBLE DRUGS AND METHODS OF PRODUCTION AND USE THEREOF
    Publication number: 20230139842
    Abstract: Microparticulate drug compositions comprising nanocrystals of poorly soluble drugs combined with a carrier are disclosed. Also disclosed are pharmaceutical compositions that include the microparticulate drug compositions. Further disclosed are methods of preparing and using the microparticulate drug compositions/pharmaceutical compositions.
    Type: Application
    Filed: December 22, 2022
    Publication date: May 4, 2023
    Inventors: Lucila GARCIA-CONTRERAS, Sevim Manolya Hatipoglu, Doris Mangiaracina Benbrook
  • COMBINATION CANCER THERAPIES
    Publication number: 20220047546
    Abstract: Drug combinations of a heteroarotinoid (e.g., SHetA2), and an Azabicyclooctan-3-one derivative (e.g., PRIMA-1 or PRIMAMET) and/or, a CDK4/6 inhibitor (e.g., Palbociclib, Abemaciclib, or Ribociclib), which are synergistically-effective as anti-cancer treatments, and kits and methods of use of such drug combinations.
    Type: Application
    Filed: September 12, 2019
    Publication date: February 17, 2022
    Inventors: Doris Mangiaracina Benbrook, Satish Kumar Ramraj
  • NANOCRYSTAL MICROPARTICLES OF POORLY SOLUBLE DRUGS AND METHODS OF PRODUCTION AND USE THEREOF
    Publication number: 20210161812
    Abstract: Microparticulate drug compositions comprising nanocrystals of poorly soluble drugs combined with a carrier are disclosed. Also disclosed are pharmaceutical compositions that include the microparticulate drug compositions. Further disclosed are methods of preparing and using the microparticulate drug compositions/pharmaceutical compositions.
    Type: Application
    Filed: February 9, 2021
    Publication date: June 3, 2021
    Inventors: Lucila GARCIA-CONTRERAS, Sevim Manolya HATIPOGLU, Doris Mangiaracina BENBROOK
  • Nanocrystal Microparticles of Poorly Soluble Drugs and Methods of Production and Use Thereof
    Publication number: 20190133939
    Abstract: Microparticulate drug compositions comprising aggregated nanocrystals of poorly soluble drugs are disclosed. Also disclosed are pharmaceutical compositions that include the microparticulate drug compositions. Further disclosed are methods of preparing and using the microparticulate drug compositions/pharmaceutical compositions.
    Type: Application
    Filed: November 7, 2018
    Publication date: May 9, 2019
    Inventors: Lucila Garcia-Contreras, Sevim Manolya Hatipoglu, Doris Mangiaracina Benbrook