Patents by Inventor Doris O'Toole

Doris O'Toole has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS
    Publication number: 20070087958
    Abstract: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: November 8, 2006
    Publication date: April 19, 2007
    Applicant: Emisphere Technologies, Inc.
    Inventors: Maria Boyd, Andrea Leone-Bay, Doris O'Toole
  • Method of preparing alkylated salicylamides via a dicarboxylate intermediate
    Publication number: 20060084646
    Abstract: The present invention relates to a method of preparing an alkylated salicylamide from a protected and activated salicylamide via a dicarboxylated salicylamide intermediate. The present invention also relates to dicarboxylic salicylamide delivery agent compounds for the delivery of active agents. Methods of administration are provided as well.
    Type: Application
    Filed: January 19, 2005
    Publication date: April 20, 2006
    Applicant: Emisphere Technologies, Inc.
    Inventors: Joseph Bernadino, Doris O'Toole, William Bay
  • Compounds and compositions for delivering active agents
    Publication number: 20050042274
    Abstract: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: December 31, 2003
    Publication date: February 24, 2005
    Inventors: David Gschneidner, Andrea Leone-Bay, Eric Wang, John Freeman, Doris O'Toole, Lynn Shields
  • Pulmonary delivery of active agents
    Patent number: 6693073
    Abstract: The present invention provides methods for administering an active agent to an animal in need of the agent by the pulmonary route. This method comprises administering via the pulmonary route, a composition comprising (a) an active agent and (b)(i) an acylated amino acid, (ii) a sulfonated amino acid, or (iii) a combination of (i) and (ii). Administration of the compositions of the present invention provide improved pulmonary delivery and greater bioavailability of the active agent than administration of the active agent alone. As a result, lesser amounts of the active agent may be administered to obtain a desired result when contained in the composition of the present invention than when administered alone.
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: February 17, 2004
    Assignee: Emisphere Technologies, Inc.
    Inventors: Sam J. Milstein, John E. Smart, Donald J. Sarubbi, Monica Leipold, Elizabeth Flanders, Doris O'Toole, Andrea Leone-Bay, David Gschneidner
  • Compounds and compositions for delivering active agents
    Publication number: 20030225300
    Abstract: Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: June 20, 2003
    Publication date: December 4, 2003
    Applicant: Emisphere Technologies Inc.
    Inventors: Andrea Leone-Bay, Doris O'Toole
  • Compounds and compositions for delivering active agents
    Patent number: 6642411
    Abstract: Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: April 19, 2001
    Date of Patent: November 4, 2003
    Assignee: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Doris O'Toole
  • Pulmonary delivery of active agents
    Publication number: 20030072740
    Abstract: The present invention provides methods for administering an active agent to an animal in need of the agent by the pulmonary route. This method comprises administering via the pulmonary route, a composition comprising (a) an active agent and (b)(i) an acylated amino acid, (ii) a sulfonated amino acid, or (iii) a combination of (i) and (ii). Administration of the compositions of the present invention provide improved pulmonary delivery and greater bioavailability of the active agent than administration of the active agent alone. As a result, lesser amounts of the active agent may be administered to obtain a desired result when contained in the composition of the present invention than when administered alone.
    Type: Application
    Filed: June 14, 2002
    Publication date: April 17, 2003
    Applicant: Emisphere Technologies, Inc.
    Inventors: Sam J. Milstein, John E. Smart, Donald J. Sarubbi, Monica Leipold, Elizabeth Flanders, Doris O'Toole, Andrea Leone-Bay, David Gschneidner
  • Pulmonary delivery of active agents
    Patent number: 6440929
    Abstract: The present invention relates to pulmonary delivery of active agents. Acylated or sufonated amino acids are used as carriers to facilitate pulmonary delivery of active agents to a target.
    Type: Grant
    Filed: April 26, 2001
    Date of Patent: August 27, 2002
    Assignee: Emisphere Technologies, Inc.
    Inventors: Sam J. Milstein, John E. Smart, Donald J. Sarubbi, Monica Leipold, Elizabeth Flanders, Doris O'Toole, Andrea Leone-Bay, David Gschneidner
  • Method of preparing salicyloylamino acids
    Patent number: 5962710
    Abstract: A method for preparing salicyloylamino acids is provided. An oligosalicylate and an amino acid are reacted to yield the salicyloylamino acid.
    Type: Grant
    Filed: May 9, 1997
    Date of Patent: October 5, 1999
    Assignee: Emisphere Technologies, Inc.
    Inventors: David Gschneidner, Doris O'Toole, John Freeman