Patents by Inventor Doris Stoffers

Doris Stoffers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR TREATING HYPOGLYCEMIC DISORDERS
    Publication number: 20240082361
    Abstract: This invention relates to methods of treating and ameliorating congenital and neonatal hyperinsulinism and post-prandial hypoglycemia, comprising the step of administering an antagonist of the Glucagon-Like Peptide-1 (GLP-1) receptor, e.g. a GLP-1 fragment or analogue thereof.
    Type: Application
    Filed: February 14, 2023
    Publication date: March 14, 2024
    Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, The Children's Hospital of Philadelphia
    Inventors: Doris STOFFERS, Diva D. DE LEON, Charles STANLEY
  • METHODS AND COMPOSITIONS FOR TREATING HYPOGLYCEMIC DISORDERS
    Publication number: 20210252110
    Abstract: This invention relates to methods of treating and ameliorating congenital and neonatal hyperinsulinism and post-prandial hypoglycemia, comprising the step of administering an antagonist of the Glucagon-Like Peptide-1 (GLP-1) receptor, e.g. a GLP-1 fragment or analogue thereof.
    Type: Application
    Filed: November 25, 2020
    Publication date: August 19, 2021
    Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, The Children's Hospital of Philadelphia
    Inventors: Doris STOFFERS, Diva D. DE LEON, Charles STANLEY
  • Methods and compositions for treating hypoglycemic disorders
    Patent number: 10987407
    Abstract: This invention relates to methods of treating and ameliorating congenital and neonatal hyperinsulinism and post-prandial hypoglycemia, comprising the step of administering an antagonist of the Glucagon-Like Peptide-1 (GLP-1) receptor, e.g. a GLP-1 fragment or analogue thereof.
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: April 27, 2021
    Assignees: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Doris Stoffers, Diva D. De Leon, Charles Stanley
  • METHODS AND COMPOSITIONS FOR TREATING HYPOGLYCEMIC DISORDERS
    Publication number: 20190336584
    Abstract: This invention relates to methods of treating and ameliorating congenital and neonatal hyperinsulinism and post-prandial hypoglycemia, comprising the step of administering an antagonist of the Glucagon-Like Peptide-1 (GLP-1) receptor, e.g. a GLP-1 fragment or analogue thereof.
    Type: Application
    Filed: January 28, 2019
    Publication date: November 7, 2019
    Inventors: Doris Stoffers, Diva D. De Leon, Charles Stanley
  • Methods and compositions for treating hypoglycemic disorders
    Patent number: 10188702
    Abstract: This invention relates to methods of treating and ameliorating congenital and neonatal hyperinsulinism and post-prandial hypoglycemia, comprising the step of administering an antagonist of the Glucagon-Like Peptide-1 (GLP-1) receptor, e.g. a GLP-1 fragment or analog thereof.
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: January 29, 2019
    Assignees: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Doris Stoffers, Diva D. De Leon, Charles Stanley
  • METHODS AND COMPOSITIONS FOR TREATING HYPOGLYCEMIC DISORDERS
    Publication number: 20180050095
    Abstract: This invention relates to methods of treating and ameliorating congenital and neonatal hyperinsulinism and post-prandial hypoglycemia, comprising the step of administering an antagonist of the Glucagon-Like Peptide-1 (GLP-1) receptor, e.g. a GLP-1 fragment or analogue thereof.
    Type: Application
    Filed: March 8, 2017
    Publication date: February 22, 2018
    Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Doris Stoffers, Diva D. DE LEON, Charles STANLEY
  • Methods and compositions for treating hypoglycemic disorders
    Patent number: 9821031
    Abstract: This invention relates to methods of treating and ameliorating congenital and neonatal hyperinsulinism and post-prandial hypoglycemia, comprising the step of administering an antagonist of the Glucagon-Like Peptide-1 (GLP-I) receptor, e.g. a GLP-I fragment or analogue thereof.
    Type: Grant
    Filed: January 8, 2008
    Date of Patent: November 21, 2017
    Assignees: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Doris Stoffers, Diva D. De Leon, Charles Stanley
  • Methods and compositions for treating hypoglycemic disorders
    Patent number: 9616108
    Abstract: This invention relates to methods of treating and ameliorating congenital and neonatal hyperinsulinism and post-prandial hypoglycemia, comprising the step of administering an antagonist of the Glucagon-Like Peptide-1 (GLP-1) receptor, e.g. a GLP-1 fragment or analog thereof.
    Type: Grant
    Filed: April 10, 2008
    Date of Patent: April 11, 2017
    Assignees: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Doris Stoffers, Diva D. De Leon, Charles Stanley
  • Modulating PDX-1 with PCIF1, methods and uses thereof
    Patent number: 9018163
    Abstract: This invention relates to PCIFl and its use as a target for the improvement of pancreatic islet ? cell mass and function in diabetes. Specifically, the invention relates to the use of compounds capable of modulating the expression or function of PClFl and their effect on the function of Pdx-1.
    Type: Grant
    Filed: March 3, 2008
    Date of Patent: April 28, 2015
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: Doris Stoffers
  • MODULATING PDX-1 WITH PCIF1, METHODS AND USES THEREOF
    Publication number: 20120003242
    Abstract: This invention relates to PCIF1 and its use as a target for the improvement of pancreatic islet ? cell mass and function in diabetes. Specifically, the invention relates to the use of compounds capable of modulating the expression or function of PCIF1 and their effect on the function of Pdx-1.
    Type: Application
    Filed: March 3, 2008
    Publication date: January 5, 2012
    Inventor: Doris Stoffers
  • METHODS AND COMPOSITIONS FOR TREATING HYPOGLYCEMIC DISORDERS
    Publication number: 20100190700
    Abstract: This invention relates to methods of treating and ameliorating congenital and neonatal hyperinsulinism and post-prandial hypoglycemia, comprising the step of administering an antagonist of the Glucagon-Like Peptide-1 (GLP-I) receptor, e.g. a GLP-I fragment or analogue thereof.
    Type: Application
    Filed: January 8, 2008
    Publication date: July 29, 2010
    Inventors: Doris Stoffers, De Leon Diva D., Charles Stanley
  • Methods and compositions for treating hypoglycemic disorders
    Publication number: 20080269130
    Abstract: This invention relates to methods of treating and ameliorating congenital and neonatal hyperinsulinism and post-prandial hypoglycemia, comprising the step of administering an antagonist of the Glucagon-Like Peptide-1 (GLP-1) receptor, e.g. a GLP-1 fragment or analogue thereof.
    Type: Application
    Filed: April 10, 2008
    Publication date: October 30, 2008
    Inventors: Doris Stoffers, Diva D. De Leon, Charles Stanley
  • Differentiation of non-insulin producing cells into insulin producing cells by GLP-1 or exendin-4 and uses thereof
    Publication number: 20070041951
    Abstract: The present invention relates to a population of insulin producing cells made by a process comprising contacting non-insulin producing cells with a growth factor selected from the group consisting of GLP-1 or Exendin-4, growth factors having amino acid sequences substantially homologous to GLP-1 or Exendin-4, and fragments thereof. The present invention also relates to methods of differentiating non-insulin producing cells into insulin producing cells and of enriching a population of cells for insulin-producing cells. The present invention also relates to methods of treating diabetes.
    Type: Application
    Filed: April 7, 2006
    Publication date: February 22, 2007
    Inventors: Josephine Egan, Riccardo Perfetti, Antonino Passaniti, Nigel Greig, Harold Holloway, Joel Habener, Doris Stoffers
  • Differentiation of non-insulin producing cells into insulin producing cells by GLP-1 or exendin-4 and uses thereof
    Patent number: 7056734
    Abstract: The present invention relates to a population of insulin producing cells made by a process comprising contacting non-insulin producing cells with a growth factor selected from the group consisting of GLP-1 or Exendin-4, growth factors having amino acid sequences substantially homologous to GLP-1 or Exendin-4, and fragmets thereof. The present invention also relates to methods of differentiating non-insulin producing cells into insulin producing cells and of enriching a population of cells for insulin-producing cells. The present invention also relates to methods of treating diabetes.
    Type: Grant
    Filed: August 10, 1999
    Date of Patent: June 6, 2006
    Assignee: The United States of America as represented by the Department of Health and Human Services, NIH
    Inventors: Josephine Egan, Riccardo Perfetti, Antonino Passaniti, Nigel Greig, Harold Holloway, Joel Habener, Doris Stoffers
  • Compositions and methods for detecting pancreatic disease
    Patent number: 6274310
    Abstract: Methods for screening a patient for pancreatic disease are disclosed and are based upon detection of a mutation in the gene encoding insulin promoter factor-1 (IPF-1) which is linked to diabetes mellitus and pancreatic agenesis.
    Type: Grant
    Filed: June 24, 1997
    Date of Patent: August 14, 2001
    Assignee: The General Hospital Corporation
    Inventors: Joel F. Habener, Doris A. Stoffers