Patents by Inventor Dorit Berlin

Dorit Berlin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Metabolic Pressure for Stem Cell Differentiation and Purification
    Publication number: 20190127691
    Abstract: Described herein are cell culture methods of producing hepatocytes, or mature, highly functional hepatocyte-like cells in vitro; cell culture media suitable for use in these methods; functional hepatocytes, or mature, highly functional hepatocyte-like cells produced by these methods; and cell compositions comprising hepatocytes, or mature, highly functional hepatocyte-like cells produced by these methods.
    Type: Application
    Filed: October 26, 2018
    Publication date: May 2, 2019
    Inventors: Timothy Petrie, Jonathan R. Coppeta, Dorit Berlin
  • Systems and methods for cell transduction
    Patent number: 10214750
    Abstract: Systems and methods are disclosed herein for use in transducing, activating, and otherwise treating cells. Cells are introduced into an inner layer of a multi-layered stack that defines at least one flow chamber and a plurality of cell entrainment regions. Vertical flow through the stack entrains the cells in the cell entrainment regions along with genetic information introduction agents or other additives, before the cells are washed using a reverse vertical flow and are collected from the device.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: February 26, 2019
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Jeffrey T. Borenstein, Joseph L. Charest, Christopher M. DiBiasio, Dorit Berlin, Jenna Balestrini, Jose A. Santos, Vishal Tandon
  • BIOPROCESSING SYSTEM
    Publication number: 20180362908
    Abstract: Systems and methods are disclosed herein for use in transducing, activating, and otherwise treating cells. Cells are introduced into an inner layer of a multi-layered stack that defines at least one flow chamber and a plurality of cell entrainment regions. Vertical flow through the stack entrains the cells in the cell entrainment regions along with genetic information introduction agents or other additives, before the cells are washed using a reverse vertical flow and are collected from the device.
    Type: Application
    Filed: August 22, 2018
    Publication date: December 20, 2018
    Inventors: Jeffrey T. Borenstein, Joseph L. Charest, Christopher M. DiBiasio, Dorit Berlin, Jenna Balestrini, Jose A. Santos, Vishal Tandon, Jason O. Fiering
  • BIOPROCESSING SYSTEM
    Publication number: 20180066219
    Abstract: Systems and methods are disclosed herein for use in transducing, activating, and otherwise treating cells. Cells are introduced into an inner layer of a multi-layered stack that defines at least one flow chamber and a plurality of cell entrainment regions. Vertical flow through the stack entrains the cells in the cell entrainment regions along with genetic information introduction agents or other additives, before the cells are washed using a reverse vertical flow and are collected from the device.
    Type: Application
    Filed: September 14, 2017
    Publication date: March 8, 2018
    Inventors: Jeffrey T. Borenstein, Joseph L. Charest, Christopher M. DiBiasio, Dorit Berlin, Jenna Balestrini, Jose A. Santos, Vishal Tandon, Jason O. Fiering
  • SYSTEMS AND METHODS FOR CELL TRANSDUCTION
    Publication number: 20170349912
    Abstract: Systems and methods are disclosed herein for use in transducing, activating, and otherwise treating cells. Cells are introduced into an inner layer of a multi-layered stack that defines at least one flow chamber and a plurality of cell entrainment regions. Vertical flow through the stack entrains the cells in the cell entrainment regions along with genetic information introduction agents or other additives, before the cells are washed using a reverse vertical flow and are collected from the device.
    Type: Application
    Filed: June 5, 2017
    Publication date: December 7, 2017
    Inventors: Jeffrey T. Borenstein, Joseph L. Charest, Christopher M. DiBiasio, Dorit Berlin, Jenna Balestrini, Jose A. Santos, Vishal Tandon