Abstract: Some aspects of the invention may be directed to a system and method of determining an occurrence of inter-vascular occlusion. The method may include: receiving, from a first sensor, a first indication, related to blood flow in a first artery supplying blood to a first hemisphere of a subject's brain; receiving from one of: the first sensor and a second sensor, a second indication related to the blood flow in a second artery supplying blood to a second hemisphere of the subject's brain; comparing the first and second indications; and determining an occurrence of an inter-vascular occlusion based on the comparison.

Abstract: Some aspects of the invention may be directed to a system and method of determining an occurrence of inter-vascular occlusion. The method may include: receiving, from a first sensor, a first indication, related to blood flow in a first artery supplying blood to a first hemisphere of a subject's brain; receiving from one of: the first sensor and a second sensor, a second indication related to the blood flow in a second artery supplying blood to a second hemisphere of the subject's brain; comparing the first and second indications; and determining an occurrence of an inter-vascular occlusion based on the comparison.

Abstract: A method and an apparatus for delivery of a therapeutic fluid to the body of a patient are provided. The apparatus includes a dispensing unit having a driving mechanism and a pumping mechanism for pumping the fluid to the body of the patient and a collapsible reservoir fillable with the therapeutic fluid for delivery thereof to the body of the patient.

Abstract: Disclosed is a therapeutic fluid reservoir to be used with an ambulatory portable infusion device. The reservoir includes a pliable shell defining a varying inner volume that varies based on the volume of therapeutic fluid held inside the reservoir, the varying inner volume having a predetermined maximum volume for containing a corresponding volume of therapeutic fluid and an outlet port for communicating fluid from the reservoir to a patient, the varying inner volume decreasing upon therapeutic fluid being communicated through the outlet port. Upon the reservoir reaching the predetermined maximum volume when being filled with therapeutic fluid, any therapeutic fluid in excess of the predetermined maximum volume driven into the reservoir causes a substantially corresponding amount of therapeutic fluid to exit out of the reservoir via the outlet port and/or at least one other port provided in the pliable shell.

Abstract: Disclosed is a therapeutic fluid reservoir to be used with an ambulatory portable infusion device. The reservoir includes a pliable shell defining a varying inner volume that varies based on the volume of therapeutic fluid held inside the reservoir, the varying inner volume having a predetermined maximum volume for containing a corresponding volume of therapeutic fluid and an outlet port for communicating fluid from the reservoir to a patient, the varying inner volume decreasing upon therapeutic fluid being communicated through the outlet port. Upon the reservoir reaching the predetermined maximum volume when being filled with therapeutic fluid, any therapeutic fluid in excess of the predetermined maximum volume driven into the reservoir causes a substantially corresponding amount of therapeutic fluid to exit out of the reservoir via the outlet port and/or at least one other port provided in the pliable shell.

Abstract: Disclosed is a therapeutic fluid reservoir to be used with an ambulatory portable infusion device. The reservoir includes a pliable shell defining a varying inner volume that varies based on the volume of therapeutic fluid held inside the reservoir, the varying inner volume having a predetermined maximum volume for containing a corresponding volume of therapeutic fluid and an outlet port for communicating fluid from the reservoir to a patient, the varying inner volume decreasing upon therapeutic fluid being communicated through the outlet port. Upon the reservoir reaching the predetermined maximum volume when being filled with therapeutic fluid, any therapeutic fluid in excess of the predetermined maximum volume driven into the reservoir causes a substantially corresponding amount of therapeutic fluid to exit out of the reservoir via the outlet port and/or at least one other port provided in the pliable shell.

Abstract: Delivery tubes having a flexible portion and pump mechanisms (4) for use therewith include features that reduce losses of an active therapeutic compound within a fluid passing through the delivery tube (17). The delivery tube can include inner (30) and outer (31) layers that are inert to reaction with the therapeutic compound and that restrict diffusion of other compounds, respectively. Rollers (83) of a peristaltic pump mechanism (80) can include structural features that reduce physical impacts on molecules of the therapeutic compound. Related systems, apparatus, and/or articles are also described.

Abstract: A method and an apparatus for delivery of a therapeutic fluid to the body of a patient are provided. The apparatus includes a dispensing unit having a driving mechanism and a pumping mechanism for pumping the fluid to the body of the patient and a collapsible reservoir fillable with the therapeutic fluid for delivery thereof to the body of the patient.

Abstract: Disclosed is a therapeutic fluid reservoir to be used with an ambulatory portable infusion device. The reservoir includes a pliable shell defining a varying inner volume that varies based on the volume of therapeutic fluid held inside the reservoir, the varying inner volume having a predetermined maximum volume for containing a corresponding volume of therapeutic fluid and an outlet port for communicating fluid from the reservoir to a patient, the varying inner volume decreasing upon therapeutic fluid being communicated through the outlet port. Upon the reservoir reaching the predetermined maximum volume when being filled with therapeutic fluid, any therapeutic fluid in excess of the predetermined maximum volume driven into the reservoir causes a substantially corresponding amount of therapeutic fluid to exit out of the reservoir via the outlet port and/or at least one other port provided in the pliable shell.