Abstract: An automated system and method for loading individual cells into individual discrete locations. The system includes a cell carrier grid, a cell carrier grid holder, a vacuum source, a liquid reservoir and a loading device facilitating communication between the above components. Application of vacuum via a port causes cells to move into individual discrete locations. The method includes the steps of placing the grid holder into a loading device, automatically filling a space in the grid holder with a liquid, automatically adding to an upper surface of the grid and automatically applying a force to the cells in so that individual cells enter at least some of the individual discrete locations. Further disclosed is an automated system for collection of data from cells further including an electro-optical scanner capable of illuminating the cells and collecting at least a portion of photons therefrom and a computerized control mechanism further controlling same.