Patents by Inventor Doron Greenbaum

Doron Greenbaum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alpha-Ketoamide Inhibitors Of Cysteine Proteases
    Publication number: 20190085024
    Abstract: The disclosure provides compounds comprising a ?-ketoamide linkage that is terminated on each end by an amino acid, such as compounds of Formula (I), wherein RA-RC are defined herein. Also provided are compositions containing these compounds and methods of inhibiting calpain activity, treating a calpain-mediated disorder, inhibiting cathepsin-B, cathepsin-L, cathepsin-S, or cathepsin-L activity, and methods of treating a cathepsin-B, cathepsin-L, cathepsin-S, or cathepsin-L mediated disorder using these compounds and compositions.
    Type: Application
    Filed: September 17, 2018
    Publication date: March 21, 2019
    Inventors: Doron Greenbaum, Russ Addis, Janet Gaboury, Swapnil Kulkami, Nataline Meinhardt
  • COMPOUNDS AND METHODS FOR TREATING MALARIA
    Publication number: 20150094294
    Abstract: The present disclosure provides compounds, specifically pyrimidin-4,6-dicarboxylic acid amide derivatives, or pharmaceutically acceptable salts thereof and pharmaceutical compositions containing said compounds. Also provided are methods for treating a mammal having malaria, or killing or inhibiting the growth of a Plasmodium species, comprising administering to said mammal or contacting said Plasmodium species with, an effective amount of a pyrimidin-4,6-dicarboxylic acid amide derivative.
    Type: Application
    Filed: February 28, 2013
    Publication date: April 2, 2015
    Inventors: Richard W. Scott, Robert W. Kavash, Wenxi Pan, Katie Freeman, Michael J. Costanzo, Doron Greenbaum, Yongjiang Xu, Trevor Young
  • ANTI-MALARIAL COMPOUNDS
    Publication number: 20150072997
    Abstract: The present invention provides tricyclic compounds, arylamide compounds, and other compounds, and compositions comprising the same, for treating malaria, and methods of treating malaria comprising administering such compounds to an animal.
    Type: Application
    Filed: August 5, 2014
    Publication date: March 12, 2015
    Inventors: Richard W. Scott, Doron Greenbaum, Dahui Liu, Xiaodong Fan, Yongjiang Xu, Haizhong Tang, Ehab Khalil
  • Anti-malarial compounds
    Patent number: 8796275
    Abstract: The present invention provides tricyclic compounds, arylamide compounds, and other compounds, and compositions comprising the same, for treating malaria, and methods of treating malaria comprising administering such compounds to an animal.
    Type: Grant
    Filed: July 28, 2009
    Date of Patent: August 5, 2014
    Assignees: The Trustees of the University of Pennsylvania, Cellceutix Corporation
    Inventors: Richard W. Scott, Doron Greenbaum, Dahui Liu, Xiaodong Fan, Yongjiang Xu, Haizhong Tang, Ehab Khalil
  • Anti-Malarial Compounds
    Publication number: 20100081665
    Abstract: The present invention provides tricyclic compounds, arylamide compounds, and other compounds, and compositions comprising the same, for treating malaria, and methods of treating malaria comprising administering such compounds to an animal.
    Type: Application
    Filed: July 28, 2009
    Publication date: April 1, 2010
    Inventors: Richard W. Scott, Doron Greenbaum, Dahui Liu, Xiaodong Fan, Yongjiang Xu, Haizhong Tang, Ehab Khalil
  • Activity-dependent cysteine protease profiling reagent
    Publication number: 20020150961
    Abstract: Probes are provided having specificity for papain cysteine hydrolases comprising an electrophile, exemplified by an epoxide, a hydrophobic group for fitting into the hydrolase pocket and a moiety that provides for detection and/or isolation. A variety of compound having hydrophobic side chains from an oligopeptide are exemplified using fluorescers, ligand members of specific binding pairs or radioactive labels for detection and/or isolation.
    Type: Application
    Filed: November 8, 2001
    Publication date: October 17, 2002
    Applicant: The Regents of the University of California Office of Technology Management
    Inventors: Matthew Bogyo, Doron Greenbaum