Patents by Inventor Dorota K. Poluha

Dorota K. Poluha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Identification of differentiation factor receptors which inhibit the tumorigenicity of neuroblastoma cells in a ligand-independent manner
    Patent number: 5789187
    Abstract: Disclosed is a method of reducing or inhibiting the tumorigenicity of a tumor cell in which a vector including a nucleotide sequence encoding a differentiation factor receptor, or a polypeptide portion thereof, is transferred to the tumor cell such that the nucleotide sequence is expressed. Tumorigenicity is monitored by cell growth and colony formation in a semi-soft medium, a reduction in proliferation being indicative of the reduction or inhibition of tumorigenicity of the treated tumor cell.
    Type: Grant
    Filed: September 21, 1994
    Date of Patent: August 4, 1998
    Assignee: Worcester Foundation for Experimental Biology
    Inventors: Alonzo H. Ross, Wojciech Poluha, Mahesh B. Lachyankar, Dorota K. Poluha
  • Treatment of tumor cells in vitro with neurotrophic factors and cell proliferation inhibitors
    Patent number: 5387520
    Abstract: Disclosed are methods and compositions for treating neuroblastoma cells. The methods include contacting the neuroblastoma cells with a neurotrophic factor and less than a lethal dose of an inhibitor of cell proliferation for about 1 to 15 days, and then maintaining the neuroblastoma cells in contact with the neurotrophic factor for an additional 1 to 15 days. The composition includes a neurotrophic factor such as the neurotropin, nerve growth factor, and an inhibitor of cell proliferation such as aphidicolin, thymidine, or hydroxyurea. Also disclosed are methods for inducing the remission or differentiation of, or eliminating, neuroblastoma cells.
    Type: Grant
    Filed: August 27, 1992
    Date of Patent: February 7, 1995
    Assignee: Worcester Foundation for Experimental Biology
    Inventors: Patrizia LoPresti, Wojciech Poluha, Dorota K. Poluha, Alonzo H. Ross