Patents by Inventor Dorota Klepacki

Dorota Klepacki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Identification and use of peptide inhibitors of protein synthesis
    Patent number: 8648035
    Abstract: The present invention discloses compositions of peptide inhibitors of protein synthesis, and methods of identifying peptide inhibitors that are capable of inhibiting protein synthesis through an interaction at a stem-loop H18 in 16S rRNA of a 30S ribosomal subunit. Screening methods for peptides are disclosed, in addition to methods of determining the affinity of a test compound for a ribosomal subunit.
    Type: Grant
    Filed: August 18, 2008
    Date of Patent: February 11, 2014
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Beatriz Llano-Sotelo, Alexander S. Mankin, Dorota Klepacki
  • PEPTIDE INHIBITORS OF PROTEIN SYNTHESIS
    Publication number: 20130267457
    Abstract: The present invention discloses compositions of peptide inhibitors of protein synthesis, and methods of identifying peptide inhibitors that are capable of inhibiting protein synthesis through an interaction at a stem-loop H18 in 16S rRNA of a 30S ribosomal subunit. Screening methods for peptides are disclosed, in addition to methods of determining the affinity of a test compound for a ribosomal subunit.
    Type: Application
    Filed: April 26, 2013
    Publication date: October 10, 2013
    Inventors: Beatriz Llano-Sotelo, Alexander S. Mankin, Dorota Klepacki
  • SYNERGISTIC ANTIBIOTIC COMBINATIONS AND DERIVATIVES
    Publication number: 20120316106
    Abstract: Improved antibiotic analogs, and synergistic combinations of antibiotics designed based on structural crystallographic analysis, are provided as well as pharmaceutical compositions that include these improved analogs and synergistic combinations, along with methods for their production and use. The synergistic combinations target neighboring sites in the ribosome demonstrating the importance of the corresponding ribosomal sites for development of clinically-relevant synergistic antibiotics.
    Type: Application
    Filed: December 29, 2010
    Publication date: December 13, 2012
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Ada Yonath, Chen Davidovich, Ella Zimmerman, Anat Bashan, Tamar Auerbach, Matthew Belousoff, Liqun Xiong, Dorota Klepacki, Alexander S. Mankin
  • IDENTIFICATION AND USE OF PEPTIDE INHIBITORS OF PROTEIN SYNTHESIS
    Publication number: 20110143998
    Abstract: The present invention discloses compositions of peptide inhibitors of protein synthesis, and methods of identifying peptide inhibitors that are capable of inhibiting protein synthesis through an interaction at a stem-loop H18 in 16S rRNA of a 30S ribosomal subunit. Screening methods for peptides are disclosed, in addition to methods of determining the affinity of a test compound for a ribosomal subunit.
    Type: Application
    Filed: August 18, 2008
    Publication date: June 16, 2011
    Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Beatriz Llano-Sotelo, Alexander S. Mankin, Dorota Klepacki