Patents by Inventor Dorothea Ambrosius

Dorothea Ambrosius has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for making neisseria or hemophilus IgA protease and DNA encoding the proteases
    Patent number: 5965424
    Abstract: The present invention concerns a process for the isolation of recombinant IgA protease from inclusion bodies. In addition a recombinant DNA is claimed which codes for an IgA protease whose C-terminal helper sequence and preferably also its N-terminal signal sequence is no longer active.
    Type: Grant
    Filed: March 18, 1994
    Date of Patent: October 12, 1999
    Assignee: Boehringer Mannheim GmbH
    Inventors: Dorothea Ambrosius, Carola Dony, Rainer Rudolph
  • Process for the reactivation of denatured protein
    Patent number: 5618927
    Abstract: The invention concerns a process for the reactivation of denatured protein, in which the protein is incubated with a solution of Tris base or/and a salt of Tris at a concentration of at least 400 mmol/l and at a pH at which the protein to be treated can take up its native conformation.
    Type: Grant
    Filed: July 2, 1992
    Date of Patent: April 8, 1997
    Assignee: Boehringer Mannheim GmbH
    Inventors: Dorothea Ambrosius, Rainer Rudolph
  • Activation of recombinant proteins
    Patent number: 5578710
    Abstract: A process for the activation of recombinant proteins which are present in at least a partially inactive form in which a protein is activated by known solubilization or/and renaturation techniques, said protein having additional helper sequences 2 to 50 amino acids in length at its N- or/and C-terminus whereby the relative hydrophobicity of these helper sequences which is calculated as the sum of the relative hydrophobicity specified in Table 1 for the individual amino acids has a negative numerical value.
    Type: Grant
    Filed: October 21, 1993
    Date of Patent: November 26, 1996
    Assignee: Boehringer Mannheim GmbH
    Inventors: Dorothea Ambrosius, Carola Dony, Rainer Rudolph