Patents by Inventor Dorothea E. Reilly

Dorothea E. Reilly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF PRODUCING TWO CHAIN PROTEINS IN BACTERIA
    Publication number: 20220162286
    Abstract: Provided herein are methods of producing a recombinant polypeptide containing two chains, such as an immune mobilizing monoclonal T-cell receptor against cancer (ImmTAC) protein including an alpha chain and a beta chain. In particular, methods are provided for producing heterologous secretory proteins in bacteria through utilization of optimized expression vectors and culture processes.
    Type: Application
    Filed: July 6, 2021
    Publication date: May 26, 2022
    Applicant: Genentech, Inc.
    Inventors: James GIULIANOTTI, Dorothea E. REILLY, Kieran AURORI, Laura C. SIMMONS
  • Methods of producing two chain proteins in bacteria
    Patent number: 11299539
    Abstract: Provided herein are methods of producing a polypeptide containing two chains, such as an antibody including a light chain and a heavy chain. In particular, methods are provided for producing heterologous secretory proteins in bacteria through utilization of optimized expression vectors and culture processes.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: April 12, 2022
    Assignee: Genentech, Inc.
    Inventors: James Giulianotti, Dorothea E. Reilly
  • Methods of producing two chain proteins in bacteria
    Patent number: 11091530
    Abstract: Provided herein are methods of producing a recombinant polypeptide containing two chains, such as an immune mobilizing monoclonal T-cell receptor against cancer (ImmTAC) protein including an alpha chain and a beta chain. In particular, methods are provided for producing heterologous secretory proteins in bacteria through utilization of optimized expression vectors and culture processes.
    Type: Grant
    Filed: July 25, 2018
    Date of Patent: August 17, 2021
    Assignee: Genentech, Inc.
    Inventors: James Giulianotti, Dorothea E. Reilly, Kieran Aurori, Laura C. Simmons
  • METHODS AND COMPOSITION FOR SECRETION OF HETEROLOGOUS POLYPEPTIDES
    Publication number: 20200148783
    Abstract: The present invention relates generally to the fields of molecular biology and protein technology. More specifically, the invention concerns signal sequences for the secretion of heterologous polypeptide from bacteria. The invention also concerns recombinant polypeptides and uses thereof.
    Type: Application
    Filed: July 18, 2019
    Publication date: May 14, 2020
    Applicant: Genentech, Inc.
    Inventors: Matthew MARRICHI, Dorothea E. REILLY
  • METHODS OF PRODUCING TWO CHAIN PROTEINS IN BACTERIA
    Publication number: 20190112368
    Abstract: Provided herein are methods of producing a polypeptide containing two chains, such as an antibody including a light chain and a heavy chain. In particular, methods are provided for producing heterologous secretory proteins in bacteria through utilization of optimized expression vectors and culture processes.
    Type: Application
    Filed: September 21, 2018
    Publication date: April 18, 2019
    Applicant: Genentech, Inc.
    Inventors: James GIULIANOTTI, Dorothea E. REILLY
  • METHODS OF PRODUCING TWO CHAIN PROTEINS IN BACTERIA
    Publication number: 20190085045
    Abstract: Provided herein are methods of producing a recombinant polypeptide containing two chains, such as an immune mobilizing monoclonal T-cell receptor against cancer (ImmTAC) protein including an alpha chain and a beta chain. In particular, methods are provided for producing heterologous secretory proteins in bacteria through utilization of optimized expression vectors and culture processes.
    Type: Application
    Filed: July 25, 2018
    Publication date: March 21, 2019
    Applicant: Genentech, Inc.
    Inventors: James GIULIANOTTI, Dorothea E. REILLY, Kieran AURORI, Laura C. SIMMONS
  • Methods and composition for secretion of heterologous polypeptides
    Patent number: 10227416
    Abstract: The present invention relates generally to the fields of molecular biology and protein technology. More specifically, the invention concerns signal sequences for the secretion of heterologous polypeptide from bacteria. The invention also concerns recombinant polypeptides and uses thereof.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: March 12, 2019
    Assignee: GENENTECH, INC.
    Inventors: Matthew Marrichi, Dorothea E. Reilly
  • METHODS AND COMPOSITION FOR SECRETION OF HETEROLOGOUS POLYPEPTIDES
    Publication number: 20140371429
    Abstract: The present invention relates generally to the fields of molecular biology and protein technology. More specifically, the invention concerns signal sequences for the secretion of heterologous polypeptide from bacteria. The invention also concerns recombinant polypeptides and uses thereof.
    Type: Application
    Filed: April 10, 2014
    Publication date: December 18, 2014
    Applicant: GENENTECH, INC.
    Inventors: Matthew Marrichi, Dorothea E. Reilly
  • Methods and composition for secretion of heterologous polypeptides
    Patent number: 8361744
    Abstract: The present invention relates generally to the fields of molecular biology and protein technology. More specifically, the invention concerns signal sequences for the secretion of heterologous polypeptide from bacteria. The invention also concerns recombinant polypeptides and uses thereof.
    Type: Grant
    Filed: November 5, 2010
    Date of Patent: January 29, 2013
    Assignee: Genentech, Inc.
    Inventors: Matthew Marrichi, Dorothea E. Reilly
  • METHODS AND COMPOSITION FOR SECRETION OF HETEROLOGOUS POLYPEPTIDES
    Publication number: 20110111408
    Abstract: The present invention relates generally to the fields of molecular biology and protein technology. More specifically, the invention concerns signal sequences for the secretion of heterologous polypeptide from bacteria. The invention also concerns recombinant polypeptides and uses thereof.
    Type: Application
    Filed: November 5, 2010
    Publication date: May 12, 2011
    Applicant: Genentech, Inc.
    Inventors: Matthew Marrichi, Dorothea E. Reilly, Laura C. Simmons