Patents by Inventor Dorothee Pflueger

Dorothee Pflueger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for diagnosing prostate cancer based on detection of SLC45A3-ELK4 fusion transcript
    Patent number: 9458213
    Abstract: RNA transcripts representing a fusion of a human SLC45A3 nucleic acid and a human ELK4 nucleic acid that are associated with prostate cancer are described. Compositions and methods useful for detection of fusion transcripts of human SLC45A3 and ELK4 genetic sequences associated with cancer and useful for cancer therapy are provided.
    Type: Grant
    Filed: February 19, 2010
    Date of Patent: October 4, 2016
    Assignee: CORNELL UNIVERSITY
    Inventors: Mark A. Rubin, Dorothee Pflueger, David S. Rickman
  • Methods of diagnosing and treating prostate cancer characterized by NDRG1-ERG fusion
    Patent number: 9090899
    Abstract: An in depth analysis of prostate cancer prostatectomy samples which over-express the ERG oncogene led to the discovery of a novel gene translocation in prostate cancer, between the NDRG1 gene (N-myc downstream regulated gene 1) on chromosome 8 and the ERG oncogene on chromosome 21, leading to the expression of a chimeric NDRG1-ERG protein. Methods and compositions useful for diagnosing and treating prostate cancer characterized by NDRG1-ERG fusion are described.
    Type: Grant
    Filed: March 8, 2010
    Date of Patent: July 28, 2015
    Assignee: CORNELL UNIVERSITY
    Inventors: Mark A. Rubin, Dorothee Pflueger, David S. Rickman
  • COMPOSITIONS AND METHODS FOR DIAGNOSING PROSTATE CANCER BASED ON DETECTION OF SLC45A3-ELK4 FUSION TRANSCRIPT
    Publication number: 20120039887
    Abstract: RNA transcripts representing a fusion of a human SLC45A3 nucleic acid and a human ELK4 nucleic acid that are associated with prostate cancer are described. Compositions and methods useful for detection of fusion transcripts of human SLC45A3 and ELK4 genetic sequences associated with cancer and useful for cancer therapy are provided.
    Type: Application
    Filed: February 19, 2010
    Publication date: February 16, 2012
    Applicant: CORNELL UNIVERSITY
    Inventors: Mark A. Rubin, Dorothee Pflueger, David S. Rickman
  • METHODS OF DIAGNOSING AND TREATING PROSTATE CANCER CHARACTERIZED BY NDRG1-ERG FUSION
    Publication number: 20120039889
    Abstract: An in depth analysis of prostate cancer prostatectomy samples which over-express the ERG oncogene led to the discovery of a novel gene translocation in prostate cancer, between the NDRG1 gene (N-myc downstream regulated gene 1) on chromosome 8 and the ERG oncogene on chromosome 21, leading to the expression of a chimeric NDRG1-ERG protein. Methods and compositions useful for diagnosing and treating prostate cancer characterized by NDRG1-ERG fusion are described.
    Type: Application
    Filed: March 8, 2010
    Publication date: February 16, 2012
    Applicant: CORNELL UNIVERSITY
    Inventors: Mark A. Rubin, Dorothee Pflueger, David S. Rickman