Patents by Inventor Dorothy E. Vatner

Dorothy E. Vatner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-sense microrna expression vectors
    Patent number: 9051568
    Abstract: The present invention relates to an alternative strategy for expressing the antisense sequence of a miRNA. This system allows for continuous production of the antisense sequence and subsequently complete knockdown of the targeted miRNA.
    Type: Grant
    Filed: April 27, 2009
    Date of Patent: June 9, 2015
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Maha Abellatif, Stephen F. Vatner, Dorothy E. Vatner, Junichi Sadoshima
  • Methods and compositions for providing cardiac protection
    Patent number: 8871735
    Abstract: The invention provides a method of reducing infarct size and/or limiting, decreasing and/or inhibiting reperfusion injury and/or ameliorating heart failure in a patient comprising administering a pharmaceutically effective amount of at least one compound capable of inhibiting AC5 to the patient. The compound capable of inhibiting AC5 is particularly effective when administered during or after reperfusion in patients suffering from an ischemic injury.
    Type: Grant
    Filed: November 5, 2012
    Date of Patent: October 28, 2014
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Stephen F. Vatner, Dorothy E. Vatner
  • Adenylyl cyclase antibodies, compositions and uses thereof
    Patent number: 8263401
    Abstract: The invention relates to compositions and methods for diagnosing and treating cardiac conditions and neurodegenerative diseases using antibodies which specifically recognize and bind to the adenylyl cyclase 5 isoform in the heart and brain. These antibodies demonstrate high specificity to the AC5 isoform and do not cross react to any other AC5 isoform. The invention further relates to methods of delivery of drugs to the site of injured tissue using the antibodies of the present invention.
    Type: Grant
    Filed: May 26, 2005
    Date of Patent: September 11, 2012
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventors: Stephen F. Vatner, Dorothy E. Vatner, Junichi Sadoshima, Jayashree Pain
  • ANTI-SENSE MICRORNA EXPRESSION VECTORS
    Publication number: 20110105592
    Abstract: The present invention relates to an alternative strategy for expressing the antisense sequence of a miRNA. This system allows for continuous production of the antisense sequence and subsequently complete knockdown of the targeted miRNA.
    Type: Application
    Filed: April 27, 2009
    Publication date: May 5, 2011
    Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
    Inventors: Maha Abdellatif, Stephen F. Vatner, Dorothy E. Vatner, Junichi Sadoshima
  • Adenylyl Cyclase Antibodies, Compositions and Uses Thereof
    Publication number: 20080274103
    Abstract: The invention relates to compositions and methods for diagnosing and treating cardiac conditions and neurodegenerative diseases using antibodies which specifically recognize and bind to the adenylyl cyclase 5 isoform in the heart and brain. These antibodies demonstrate high specificity to the AC5 isoform and do not cross react to any other AC5 isoform. The invention further relates to methods of delivery of drugs to the site of injured tissue using the antibodies of the present invention.
    Type: Application
    Filed: May 26, 2005
    Publication date: November 6, 2008
    Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
    Inventors: Stephen F. Vatner, Dorothy E. Vatner, Junichi Sadoshima, Jayashree Pain