Patents by Inventor Dorothy Marquis-Omer

Dorothy Marquis-Omer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Controlled-pH formulation for intravesicular instillation of TGF.alpha.PE.sub.40 ab
    Patent number: 5612313
    Abstract: A buffered intravesicular pharmaceutical dosage system for delivery of TGF.alpha.PE.sub.40 ab to a human bladder for bladder cancer chemotherapy, in which a buffer system of 100 mM phosphate at an initial pH of 7.8 maintains a pH range in the bladder of 6.5 to 7.8 that is sufficient to maximize interaction of TGF.alpha.PE.sub.40 ab with the EGF receptor expressed on the surface of bladder cancer cells and to prevent aggregation of the TGF.alpha.PE.sub.40 ab while in the bladder.
    Type: Grant
    Filed: June 27, 1996
    Date of Patent: March 18, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Dorothy Marquis-Omer, C. Russell Middaugh, Gautam Sanyal