Patents by Inventor Dorthe Christensen Almholt

Dorthe Christensen Almholt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Live cell procedures to identify to identify compounds modulating intracellular distribution of phosphodiesterase( pde) enzymes
    Publication number: 20030187056
    Abstract: An alternative therapeutic approach for PDE4 inhibition is disclosed. PDE4 dislocators, will remove the PDE4 away from the native location in the cell and thereby increase the concentration of cAMP in this location. By dislocating the PDE4, and thereby not acting directly on the catalytic, among phosphodiesterase inhibitors, well conserved site, the compound will act e.g. at the binding domain of the PDE4, thereby providing isoform-specific ‘inhibitors’ of PDE4. The dislocation of PDE4s are visualised with fusions to GFP. The native location is induced by treatment with Rolipram.
    Type: Application
    Filed: March 13, 2003
    Publication date: October 2, 2003
    Inventors: Bernard Robert Terry, Kurt Marshall Scudder, Sara Petersen Bjorn, Ole Thastrup, Dorthe Christensen Almholt, Morten Praestegaard