Patents by Inventor Dos D. Sarbassov

Dos D. Sarbassov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER CELLS BY INDUCTION OF CYTOTOXIC OXIDATIVE STRESS
    Publication number: 20210196753
    Abstract: Provided herein are methods and compositions for the treatment of cancers with D-VC and arsenic trioxide. In some aspects, cancers for treatment according to the embodiments include cancers with increased GLUT1 expression and/or comprise KRAS mutation.
    Type: Application
    Filed: August 20, 2019
    Publication date: July 1, 2021
    Applicant: Board of Regents, The University of Texas System
    Inventors: Dos D. SARBASSOV, Xinggang WU, Lee ELLIS, Rajat BHATTACHARYA
  • Methods Relating to Mammalian Rictor Polypeptide
    Patent number: 8999660
    Abstract: The invention describes isolated mTOR-associated proteins (“mTOR-APs”) as well as isolated variants and fragments thereof and the isolated nucleic acids encoding them. The invention also describes vectors and host cells containing nucleic acid encoding an mTOR-AP polypeptide and methods for producing an mTOR-AP polypeptide. Also described are methods for screening for compounds which modulate mTOR-AP activity and methods for treating or preventing a disorder that is responsive to mTOR-AP modulation.
    Type: Grant
    Filed: August 13, 2012
    Date of Patent: April 7, 2015
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: David M. Sabatini, Do-Hyung Kim, Dos D. Sarbassov
  • mTOR KINASE-ASSOCIATED PROTEINS
    Publication number: 20130137633
    Abstract: The invention describes isolated mTOR-associated proteins (“mTOR-APs”) as well as isolated variants and fragments thereof and the isolated nucleic acids encoding them. The invention also describes vectors and host cells containing nucleic acid encoding an mTOR-AP polypeptide and methods for producing an mTOR-AP polypeptide. Also described are methods for screening for compounds which modulate mTOR-AP activity and methods for treating or preventing a disorder that is responsive to mTOR-AP modulation.
    Type: Application
    Filed: August 13, 2012
    Publication date: May 30, 2013
    Applicant: Whitehead Institute for Biomedical Research
    Inventors: David M. Sabatini, Do-Hyung Kim, Dos D. Sarbassov
  • mTOR kinase-associated proteins
    Patent number: 8258271
    Abstract: The invention describes isolated mTOR-associated proteins (“mTOR-APs”) as well as isolated variants and fragments thereof and the isolated nucleic acids encoding them. The invention also describes vectors and host cells containing nucleic acid encoding an mTOR-AP polypeptide and methods for producing an mTOR-AP polypeptide. Also described are methods for screening for compounds which modulate mTOR-AP activity and methods for treating or preventing a disorder that is responsive to mTOR-AP modulation.
    Type: Grant
    Filed: May 17, 2006
    Date of Patent: September 4, 2012
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: David M. Sabatini, Do-Hyung Kim, Dos D. Sarbassov
  • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    Patent number: 7906308
    Abstract: In certain aspects, the invention relates to methods for identifying compounds which modulate Akt activity mediated by the rictor-mTOR complex and methods for treating or preventing a disorder that is associated with aberrant Akt activity.
    Type: Grant
    Filed: January 27, 2006
    Date of Patent: March 15, 2011
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: David M. Sabatini, Dos D. Sarbassov
  • Phosphorylation and regulation of AKT/PKB by the rictor-mTOR complex
    Publication number: 20100173928
    Abstract: In certain aspects, the invention relates to methods for identifying compounds which modulate Akt activity mediated by the rictor-mTOR complex and methods for treating or preventing a disorder that is associated with aberrant Akt activity.
    Type: Application
    Filed: July 15, 2008
    Publication date: July 8, 2010
    Inventors: David M. Sabatini, Dos D. Sarbassov, Michael Andreeff, Marina Konopleva, Zhihong Zeng, Francis J. Giles
  • mTOR kinase-associated proteins
    Patent number: 7052870
    Abstract: The invention describes isolated mTOR-associated proteins (“mTOR-APs”) as well as isolated variants and fragments thereof and the isolated nucleic acids encoding them. The invention also describes vectors and host cells containing nucleic acid encoding an mTOR-AP polypeptide and methods for producing an mTOR-AP polypeptide. Also described are methods for screening for compounds which modulate mTOR-AP activity and methods for treating or preventing a disorder that is responsive to mTOR-AP modulation.
    Type: Grant
    Filed: February 18, 2004
    Date of Patent: May 30, 2006
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: David M. Sabatini, Do-Hyung Kim, Dos D. Sarbassov
  • mTOR kinase-associated proteins
    Publication number: 20040253677
    Abstract: The invention describes isolated mTOR-associated proteins (“mTOR-APs”) as well as isolated variants and fragments thereof and the isolated nucleic acids encoding them. The invention also describes vectors and host cells containing nucleic acid encoding an mTOR-AP polypeptide and methods for producing an mTOR-AP polypeptide. Also described are methods for screening for compounds which modulate mTOR-AP activity and methods for treating or preventing a disorder that is responsive to mTOR-AP modulation.
    Type: Application
    Filed: February 18, 2004
    Publication date: December 16, 2004
    Applicant: Whitehead Institute for Biomedical Research
    Inventors: David M. Sabatini, Do-Hyung Kim, Dos D. Sarbassov