Abstract: Sheets of material used in medical devices and filters are disclosed. The sheets may include a fibrous mat including a plurality of microfibers. The microfibers may include a polymer matrix and a plurality of additive particles. The additive particles may include carbon material particles, therapeutic micro particles, and any combination thereof. Medical devices and filters that use the sheets are disclosed. Methods of producing the sheets are also disclosed.

Abstract: Devices used to provide vascular access, methods of manufacture, and methods of use are disclosed. The devices may be a vascular graft having a wall configured to seal following repeated punctures with a needle. The wall may include a plurality of layers of differing materials. The wall may also include a bead configured to prevent kinking of the vascular graft. The bead may be spirally wrapped around the vascular graft or be discrete C-shaped beads that provide a gap for needle access.