Abstract: Described herein is a method, and compositions useful with the method, of analyzing a tissue from a subject. The method includes contacting a probe conjugate (10) including a probe molecule (12), to a biological tissue 146 from a subject. The probe conjugate (10) is contacted with the biological tissue (14) under a well defined and easily controlled force field(s) and that tends to result in an interaction between the molecular probe (12) and the tissue (14) and/or tends to disrupt such interactions. The resulting interaction of the molecular probe (12) with the tissue (14) is then quantified. The analytical methods may be useful for diagnostic and prognostic applications as well as in the discovery of novel drug delivery systems and novel therapeutic substances and targets.