Abstract: In accordance with the present invention there is provided a method, device, and kit for the diagnosis and assessment of andropause and/or reduced gonadal function. The method comprises conducting a biological assay on a male fluid sample and determining the presence of one or more clinical markers of andropause at a concentration indicative of andropause. The method of the present invention is simple, rapid and non-invasive. The method can be conducted privately by the patient at home with almost instantaneous results. Based on the results the patient can then seek professional medical help leading to earlier treatment and alleviation of andropausal symptoms and any associated medical conditions.