Abstract: An applicator instrument for dispensing surgical fasteners includes a housing, and an elongated shaft extending from the housing. The elongated shaft has a proximal end secured to the housing, a distal end spaced from the proximal end, and a first axis extending between the proximal and distal ends of the elongated shaft. Surgical fasteners are disposed in the elongated shaft. The surgical fasteners are stacked at an angle relative to the first axis of the elongated shaft. A distal end cap having a surgical fastener dispensing window is secured to the distal end of the elongated shaft. The applicator instrument has a firing system disposed in the housing, and an actuator coupled with the firing system for activating the firing system to dispense the surgical fasteners through the surgical fastener dispensing window.

Abstract: The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 40 kDa mesothelin polypeptide, which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of mesothelin in the progression of disorders associated with cancer. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.

Abstract: The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 40 kDa mesothelin polypeptide, which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of mesothelin in the progression of disorders associated with cancer. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.

Abstract: The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 4O.kDa mesothelin polypeptide, which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of mesothelin in the progression of disorders associated with cancer. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.

Abstract: The present inventor(s) conceived of, among other things, a consumer healthcare portal to help consumers make well-informed healthcare decisions. One exemplary portal incorporates existing healthcare claims data from payers to provide personalized offerings around health plan selection and treatment options guidance. This data also provides the ability for consumers to assess the effectiveness of various physicians in their plans. Additionally, the exemplary portal provides a consumer messaging capability that facilitates automatic transmission of personalized healthcare communications geared to change individual consumer behavior.

Abstract: A wheeled exercise device that facilitates various physical exercises is provided. In one embodiment, a device includes a shaft, a handle, a first wheel and a second wheel connected to the shaft with the handle located between the first wheel and the second wheel. The device also includes an attachment point operably connected to the shaft with the attachment point located radially outward of an outer surface of the handle and capable of rotation about a central axis of the shaft.

Abstract: The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 4O.kDa mesothelin polypeptide, which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of mesothelin in the progression of disorders associated with cancer. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.

Abstract: A utensil for preparing filled food items, such as tacos, pastries or dumplings, is disclosed, having a pair of engaging clamping molds, pivotally connected by a hinge assembly. Each clamping mold has a preconfigured form in the shape of the desired resulting, food item, generally comprising a hollow, concave center and a flattened perimeter. Together, the two clamping molds and the attached hinge assembly form a clamping assembly. The clamping assembly is in the open position when the perimeters of the opposing clamping surfaces are disengaged and in the same plane. In this position, a flat bread or tortilla is placed on the surfaces and a filling is laid on top. The clamping assembly is in the closed position when the perimeters of the opposing clamping surfaces are engaged. When the clamping assembly is closed the perimeter edges of the tortilla are sandwiched between the clamping surfaces and the filling is enclosed within.