Patents by Inventor Doug W. Chan

Doug W. Chan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA dependent protein kinase catalytic subunit phosphorylation sites and antibodies thereto
    Patent number: 7491804
    Abstract: The identification and use of two major DNA-PKcs autophosphorylation sites. Threonine (T) 2609 and Serine (S) 2056, including antibodies specific for phosphorylated T2609 and 52056. Peptides and polynucleotides encoding same, that feature these two sites of phosphorylation. The antibodies do not bind to the unphosphorylated DNA-PKcs protein or peptide, thus providing diagnostic tools to monitor the effectiveness of treatments which target the DNA repair pathway of cancer cells, and the ability to intervene or inhibit in phosphorylation of T2609 or 52056, either through application of a drug or an antibody, to increase the radiosensitivity of cancer cells.
    Type: Grant
    Filed: April 21, 2003
    Date of Patent: February 17, 2009
    Assignee: The Regents of the University of California
    Inventors: David J. Chen, Ping-Chi Benjamin Chen, Doug W. Chan