Patents by Inventor Douglas A. Best

Douglas A. Best has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230068750
    Abstract: Dimer and monomer molecules according to general formulas (I) or (II) are useful as lipid switch molecules when incorporated into a membrane of a liposome. wherein R1 is a hydrophobic tail having at least 6 carbons and wherein R2 is selected from the group consisting of —NH2, wherein, for the dimer, the linker is a saturated carbon chain having 2 to 6 carbons or is a para-xylene linker; and when R2 is charged anions are present to render the charge neutral. These molecules can bind ATP or similar small phosphorylated molecules between R2 groups, which changes the shape of the molecule or the molecules orientation within the membrane thereby acting as a “switch” to release a therapeutic agent from the liposome.
    Type: Application
    Filed: August 1, 2022
    Publication date: March 2, 2023
    Applicant: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
    Inventors: Jinchao Lou, Jennifer Schuster, Francisco Nicolas Barrera Olivares, Michael Douglas Best
  • Patent number: 7252400
    Abstract: An illuminated indicator is disclosed. The illuminated indicator includes graphics disposed on a rear surface of a lightpipe and a housing that supports the rear surface of lightpipe. The housing defines an outer perimeter light channel. The illuminated indicator also includes a plurality of light sources that are disposed about the outer perimeter light channel. The outer perimeter light channel directs light from the plurality of light sources to an outer perimeter edge of the lightpipe to evenly illuminate the graphics.
    Type: Grant
    Filed: October 15, 2004
    Date of Patent: August 7, 2007
    Assignee: Delphi Technologies, Inc.
    Inventors: Mark J. Clugston, David L. Brooks, Kenneth D. Perry, Randall J. Heidtman, Gail M. Sylvester, Douglas A. Best
  • Publication number: 20050128733
    Abstract: An illuminated indicator is disclosed. The illuminated indicator includes graphics disposed on a rear surface of a lightpipe and a housing that supports the rear surface of lightpipe. The housing defines an outer perimeter light channel. The illuminated indicator also includes a plurality of light sources that are disposed about the outer perimeter light channel. The outer perimeter light channel directs light from the plurality of light sources to an outer perimeter edge of the lightpipe to evenly illuminate the graphics.
    Type: Application
    Filed: October 15, 2004
    Publication date: June 16, 2005
    Inventors: Mark Clugston, David Brooks, Kenneth Perry, Randall Heidtman, Gail Sylvester, Douglas Best