Abstract: Interative, preferably computer based iterative processes for generating synthetic compounds with desired physical, chemical and/or bioactive properties, i.e., active compounds, are provided. During iterations of the processes, a target nucleic acid sequence is provided or selected, and a library of candidate nucleobase sequences is generated in silico according to defined criteria. A “virtual” oligonucleotide chemistry is chosen and a library of virtual oligonucleotide compounds having the selected nucleobase sequences is generated. These virtual compounds are reviewed and compounds predicted to have particular properties are selected. The selected compounds are robotically synthesized and are preferably robotically assayed for a desired physical, chemical or biological activity. Active compounds are thus generated and, at the same time, preferred sequences and regions of the target nucleic acid that are amenable to oligonucleotide or sequence-based modulation are identified.

Abstract: The present invention relates generally to lysosomal storage disorders and to diagnostic agents for their detection in humans and other animals. More particularly, the present invention is directed to the uses of the LSD markers Lamp-1, Lamp-2, Limp-II, 4-sulphatase, acid phosphatase (ACP), &bgr;-hexasaminidase or &agr;-mannosidase, amongst others as diagnotic agents for the detection of many lysosomal storage disorders.

Abstract: The present invention relates generally to lysosomal storage disorders and to diagnostic agents for their detection in humans and other animals. More particularly, the present invention is directed to the uses of the LSD markers Lamp-1, Lamp-2, Limp-II, 4-sulphatase, acid phosphatase (ACP), &bgr;-hexosaminidase or &agr;-mannosidase, amongst others as diagnotic agents for the detection of many lysosomal storage disorders.

Abstract: A method for recovering densified plastic from mixed waste containing plastic and less than about 15 weight percent paper, and having a density ranging from about 2 to about 3 pounds per cubic foot, the method comprising the steps of shredding the mixed waste at ambient conditions; charging a batch of shredded waste weighing from about 250 to about 650 lbs. to a densifier; further shredding the mixed waste inside the densifier with a motor-driven rotating blade while monitoring surface temperature of the plastic inside the densifier, amperage drawn by the motor-driver and vibration level within the densifier; continuously shredding waste inside the densifier for a period ranging from about 5 to about 20 minutes, until the surface temperature of the plastic reaches at least about 220.degree. F.

Abstract: A system, method, and components for removably securing communication cables to the upper portion of work station divider panels is shown. Key to the installation is the telecommunication removable raceway which contains an upper inverted U-shaped cover, and a mating H-shaped panel grip channel. The H-shaped lower channel has a pair of lower legs depending from a central web, and upper legs extending upwardly from the web to matingly engage the inverted U-shaped member. The lower legs are proportioned to flexibly and clampingly engage the upper portion of the work station divider. A top feed tube is provided to lead the cabling downwardly from inside the drop ceiling or other ceiling portion, and coact with a top feed cap which is provided at preselected stations along the main raceway to interrupt the inverted U-shaped cover.

Abstract: A system and method for removing fine cellulosic contaminants from plastic film utilizing a plurality of tanks, means for moving the plastic film sequentially through the tanks, means for recirculating an aqueous solution through each of the tanks, means for filtering the recirculating aqueous solution, and means for injecting flocculant into the recirculating solution. The subject system preferably includes at least two independent circulation modules, each having means for recirculating and filtering an aqueous solution and for minimizing liquid carry-over from one module to another. The system also preferably includes means for monitoring the turbidity of the recirculating aqueous solution and for injecting flocculant into the recirculating solution whenever the turbidity exceeds a predetermined maximum value.

Abstract: A method for recycling waste plastic material, from polymeric film or hydropulper waste, including plastic and cellulosic fiber or organic contaminants. The method includes the steps of introducing the waste plastic material into a size reduction unit, and reducing the size of the waste plastic material to particles having a maximum dimension ranging between about 1 inch and about 8 inches; mechanically hammering and rubbing the plastic material for separating a portion of the cellulosic fiber from the plastic; separating another portion of the cellulosic fiber from the plastic by flotation with agitation; further reducing the particle size of the plastic to a maximum dimension of about 1/2inch; dewatering the plastic; drying the plastic to a moisture content of less than about 10 weight percent; and rolling the plastic into pellets.

Abstract: A shredder including a shredder housing having an inside, an outside, side walls, end walls, such that the end walls and side walls are engineered and joined together to maintain tight tolerance within the shredder. The end walls and side walls define a top inlet opening and a bottom outlet opening. Two parallel spaced apart shafts are horizontally aligned with each other and rotationally mounted through the end walls for receiving rotational power. Adjustable speed rotational motors engage each of the shafts for rotating them in counter-rotational directions. A plurality of uniform thickness disk-shaped blades are alternatingly positioned with interposed disk-shaped spacers placed therebetween. The spacers have a thickness slightly thicker than the blades.

Abstract: A method for recycling waste plastic material, from polymeric film or hydropulper waste, including plastic and cellulosic fiber or organic contaminants. The method includes the steps of introducing the waste plastic material into a size reduction unit, and reducing the size of the waste plastic material to particles having a maximum dimension ranging between about 1 inch and about 8 inches; mechanically hammering and rubbing the plastic material for separating a portion of the cellulosic fiber from the plastic; separating another portion of the cellulosic fiber from the plastic by flotation with agitation; further reducing the particle size of the plastic to a maximum dimension of about 1/2 inch; dewatering the plastic; drying the plastic to a moisture content of less than about 10 weight percent; and rolling the plastic into pellets.

Abstract: A method for producing rolled plastic pellets comprising from about 5 to about 10 weight percent cellulosic fiber and less than about 10 weight percent water from mixed plastic waste comprising polymeric film.