Patents by Inventor Douglas A. Collins

Douglas A. Collins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Adenosyl-cobalamin fortified compositions
    Publication number: 20030018009
    Abstract: The invention provides food, drink, supplement or other compositions containing a fortifying amount of adenosylcobalamin.
    Type: Application
    Filed: June 20, 2002
    Publication date: January 23, 2003
    Inventor: Douglas A. Collins
  • Transcobalamin receptor binding conjugates useful for treating abnormal cellular proliferation
    Publication number: 20020151525
    Abstract: An agent, composition and method for the treatment, prophylaxis and/or diagnosis of proliferative disorders, which is highly and efficiently absorbed at the site of abnormal cellular proliferation is disclosed.
    Type: Application
    Filed: October 25, 2001
    Publication date: October 17, 2002
    Inventors: Douglas A. Collins, Henricus P.C. Hogenkamp
  • Cobalamin compounds useful as antibiotic agents and as imaging agents
    Publication number: 20020042394
    Abstract: The invention provides cobalamin derivatives linked to an antibiotic and/or an imaging agent, as well as pharmaceutical compositions comprising the compounds and methods for using the compounds in treatment or diagnosis of a microbial infection.
    Type: Application
    Filed: May 31, 2001
    Publication date: April 11, 2002
    Inventors: Henricus P.C. Hogenkamp, Douglas A. Collins
  • Radionuclide labeling of vitamin B12 and coenzymes thereof
    Patent number: 6211355
    Abstract: A compound useful for in vivo imaging of organs and tumors is provided of formula: wherein is a cobalamin, is derived from a corrin carboxylic acid group of said cobalamin, Y is a linking group and X is a chelating group, optionally comprising a detectable radionuclide or a paramagnetic metal ion, and n is 1-3.
    Type: Grant
    Filed: February 8, 2000
    Date of Patent: April 3, 2001
    Assignees: Mayo Foundation for Medical Education and Research, Regents of the University of Minnesota
    Inventors: Douglas A. Collins, Henricus Petrus Hogenkamp
  • Radionuclide labeling of vitamin B.sub.12 and coenzymes thereof
    Patent number: 6096290
    Abstract: A compound useful for in vivo imaging of organs and tumors is provided of formula: ##STR1## wherein ##STR2## is a cobalamin, ##STR3## is derived from a corrin carboxylic acid group of said cobaltmin, Y is a linking group and X is a chelating group, optionally comprising a detectable radionuclide or a paramagnetic metal ion, and n is 1-3.
    Type: Grant
    Filed: July 15, 1999
    Date of Patent: August 1, 2000
    Assignees: Regents of the University of Minnesota, Mayo Foundation for Medical Education and Research
    Inventors: Douglas A. Collins, Henricus Petrus Hogenkamp
  • Radionuclide labeling of vitamin B.sub.12 and coenzymes thereof
    Patent number: 6004533
    Abstract: A compound useful for in vivo imaging of organs and tumors is provided of formula: ##STR1## wherein ##STR2## is a cobalamin, ##STR3## is derived from a corrin carboxylic acid group of said cobalamin, Y is a linking group and X is a chelating group, optionally comprising a detectable radionuclide or a paramagnetic metal ion, and n is 1-3.
    Type: Grant
    Filed: April 13, 1998
    Date of Patent: December 21, 1999
    Assignees: Mayo Medical Ventures, Regents of the University of Minnesota
    Inventors: Douglas A. Collins, Henricus Petrus Hogenkamp
  • Wafer carriers for epitaxial growth processes
    Patent number: 6001183
    Abstract: A wafer carrier/susceptor combination for use in an epitaxial deposition process has a configuration which provides greater thermal conductivity between the susceptor and the wafer carrier in regions substantially underlying the wafers than in regions not underlying the wafers. This difference in thermal conductivity is produced by configuring the wafer carrier or susceptor so that the lower surface of the wafer carrier is disposed closer to the susceptor in regions substantially underlying the wafers than in at least some regions not underlying the wafers. By controlling the thermal conductivity so that it is greater in certain regions than in other regions, the temperature difference between the wafers and the surface of the wafer carrier can be reduced, and a more uniform temperature distribution across the surface of the wafer can be achieved. As a result, the combination may be used to deposit a more uniform coating across the entire surface of each wafer.
    Type: Grant
    Filed: September 30, 1996
    Date of Patent: December 14, 1999
    Assignee: Emcore Corporation
    Inventors: Alexander I. Gurary, Eric A. Armour, Douglas A. Collins, Richard A. Stall
  • Near real-time extraction of deposition and pre-deposition characteristics from rotating substrates and control of a deposition apparatus in near real-time
    Patent number: 5772758
    Abstract: Methods and apparatus are provided for monitoring deposition and pre-deposition characteristics such as the growth rates, oxide desorption, surface reconstruction, anion surface exchange reaction and smoothness of the surface of rotating substrates in near real-time during molecular beam epitaxy by processing the data in the time domain and for controlling a deposition apparatus in near real-time.
    Type: Grant
    Filed: February 15, 1996
    Date of Patent: June 30, 1998
    Assignee: California Institute of Technology
    Inventors: Douglas A. Collins, Thomas C. McGill, George O. Papa
  • Radionuclide labeling of vitamin B.sub.12 and coenzymes thereof
    Patent number: 5739313
    Abstract: A compound useful for in vivo imaging of organs and tumors is provided of formula: ##STR1## wherein ##STR2## is a cobalamin, ##STR3## is derived from a corrin carboxylic acid group of said cobalamin, Y is a linking group and X is a chelating group, optionally comprising a detectable radionuclide or a paramagnetic metal ion, and n is 1-3.
    Type: Grant
    Filed: November 13, 1995
    Date of Patent: April 14, 1998
    Assignees: Regents of the University of Minnesota, Mayo Foundation for Medical Education and Research
    Inventors: Douglas A. Collins, Henricus Petrus Hogenkamp