Abstract: The invention relates to the identification of fusion proteins comprising polypeptide and protein variants of fibroblast growth factor 21 (FGF21) with improved pharmaceutical properties. Also disclosed are methods for treating FGF21-associated disorders, including metabolic conditions.

Abstract: A combustor assembly for a gas turbine engine defining a radial direction and a circumferential direction includes a liner assembly at least partially defining a combustion chamber and including at least one liner formed of a ceramic matrix composite material and extending between a downstream end and an upstream end, the downstream end of the at least one liner defining an interface surface extending along the circumferential direction; and a seal member also formed of a ceramic matrix composite material and bonded to the interface surface of the at least one liner, the seal member defining a downstream surface for contacting an adjacent component to form a seal with the adjacent component.

Abstract: A mouth rinse composition with a cationic antimicrobial agent and an anti-stain agent, which is a functionalized polyethylene glycol. A dentifrice composition with a cationic antimicrobial agent and an anti-stain agent, which is a functionalized polyethylene glycol. The cationic antimicrobial agent is a quaternary ammonium salt, such as cetyl pyridinium chloride, or a metal ion source, such as stannous fluoride.

Abstract: A hair clipper is provided, including a chassis having upper and lower chassis portions defining an enclosed interior chamber, said upper and lower chassis portions configured for being secured together; and an outer housing including upper and lower housing portions constructed and arranged for enclosing the chassis as the housing portions are secured together such that the interior chamber is isolated from the housing.

Abstract: Provided is a method of enhancing an antigen-induced long-lasting immune response in a host comprising administering to a host an effective amount of: (a) a nonpathogenic recombinant rabies virus comprising at least three copies of a mutated G gene, wherein said mutated G gene encodes a rabies virus glycoprotein wherein the glycoprotein amino acid 194 is serine and the glycoprotein amino acid 333 is glutamic acid, wherein said recombinant rabies virus does not express a foreign protein antigen; and (b) a Coronavirus antigen that is not expressed by the rabies virus. Also provided are related compositions, kits and vaccines.

Abstract: A timber-working device has a frame, and a saw apparatus mounted to the frame. At least one pair of arms are pivotally attached to the frame and configured to be controlled to grasp at least one tree stem. A feed mechanism is configured to feed the at least one stem relative to the frame. The feed mechanism has opposing feed arms, each feed arm pivotally connected to the frame. Each feed arm has a pivot pin arrangement with a first pivot pin and a second pivot pin, where the first pivot pin and the second pivot pin are aligned along a common longitudinal axis. An air gap is provided between the between the first pivot pin and the second pivot pin along the common longitudinal axis.

Abstract: A hair clipper is provided, including a chassis having upper and lower chassis portions defining an enclosed interior chamber, said upper and lower chassis portions configured for being secured together; and an outer housing including upper and lower housing portions constructed and arranged for enclosing the chassis as the housing portions are secured together such that the interior chamber is isolated from the housing.

Abstract: Provided herein are methods of treating cancer or an autoimmune disease comprising administering a liposome that comprises neutral phospholipids and a P-ethoxy oligonucleotide that targets a IGF-1R-encoding polynucleotide.

Abstract: Disclosed are oral care compositions having reduced tooth staining propensity and comprising in a pharmaceutically acceptable carrier, a cationic antimicrobial agent and an anti-stain agent comprising one or more materials from each of at least two of the following chemical groups: Group 1. anionic agents, Group 2. aldehydes, ketones, and other reactive carbonyl compounds and Group 3. nonionic ethoxylated surfactants. Examples of cationic antimicrobial agent include quaternary ammonium compounds such as cetylpyridinium chloride, cetyl pyridinium fluoride, tetradecylpyridinium chloride, N-tetradecyl-4-ethyl pyridinium chloride and domiphen bromide; chlorhexidine; and metal ion sources to supply metal ions such as stannous, zinc or copper.

Abstract: A modular enclosure system includes a plurality of anchor rails configured to be mounted to a surface such as a wall to which the modular enclosure system is to be attached. The modular enclosure system includes a first partition having a plurality of partition segments and a second partition having a plurality of partition segments. The first partition and the second partition are each coupled to a first rail and a second rail of the plurality of anchor rails.

Abstract: Disclosed are oral care compositions having reduced tooth staining propensity and comprising in a pharmaceutically acceptable carrier, a cationic antimicrobial agent and an anti-stain agent comprising one or more materials from each of at least two of the following chemical groups: Group 1. anionic agents, Group 2. aldehydes, ketones, and other reactive carbonyl compounds and Group 3. nonionic ethoxylated surfactants. Examples of cationic antimicrobial agent include quaternary ammonium compounds such as cetylpyridinium chloride, cetyl pyridinium fluoride, tetradecylpyridinium chloride, N-tetradecyl-4-ethyl pyridinium chloride and domiphen bromide; chlorhexidine; and metal ion sources to supply metal ions such as stannous, zinc or copper.

Abstract: A mouth rinse composition with a cationic antimicrobial agent and an anti-stain agent, which is a functionalized polyethylene glycol. A dentifrice composition with a cationic antimicrobial agent and an anti-stain agent, which is a functionalized polyethylene glycol. The cationic antimicrobial agent is a quaternary ammonium salt, such as cetyl pyridinium chloride, or a metal ion source, such as stannous fluoride.

Abstract: The disclosure provides methods of producing neoantigens, comprising bringing a tumor cell culture in contact with an antisense oligonucleotide; and further, recovering the neoantigens; as well as immunogenic compositions comprising these neoantigens. The disclosure further provides methods of inducing an immune response in a subject against a cancer such as glioblastoma; and methods of treating a cancer such as glioblastoma in a subject comprising administering to the subject a therapeutically effective amount of the neoantigens and compositions disclosed herein.

Abstract: The present disclosure relates to compositions and methods for treating breast cancer using antisense (AS) nucleic acids directed against Insulin-like Growth Factor 1 Receptor (IGF-1R). The AS may be administered to the patients systemically, or may be used to produce an autologous cancer cell vaccine. In embodiments, the AS are provided in an implantable irradiated biodiffusion chamber comprising tumor cells and an effective amount of the AS. The chambers are irradiated and implanted in the abdomen of subjects and stimulate an immune response that attacks tumors distally. The compositions and methods disclosed herein may be used to treat many different kinds of breast cancer, including metastatic breast cancer.

Abstract: The present disclosure relates to compositions and methods for treating liver cancers, especially hepatocellular carcinoma, using antisense (AS) nucleic acids directed against Insulin-like Growth Factor 1 Receptor (IGF-1R). The AS may be administered to the patients systemically, or may be used to produce an autologous cancer cell vaccine. In embodiments, the AS are provided in an implantable irradiated biodiffusion chamber comprising tumor cells and an effective amount of the AS. The chambers are irradiated and implanted in the abdomen of subjects and stimulate an immune response that attacks tumors distally. The compositions and methods disclosed herein may be used to treat many different kinds of liver cancer.

Abstract: The present invention provides compositions and methods for discriminating infectious from non-infectious CNS disorders, and providing appropriate treatment thereof.

Abstract: A mouth rinse composition with a cationic antimicrobial agent and an anti-stain agent, which is a functionalized polyethylene glycol. A dentifrice composition with a cationic antimicrobial agent and an anti-stain agent, which is a functionalized polyethylene glycol. The cationic antimicrobial agent is a quaternary ammonium salt, such as cetyl pyridinium chloride, or a metal ion source, such as stannous fluoride.

Abstract: A combustor assembly for a gas turbine engine defining a radial direction and a circumferential direction includes a liner assembly at least partially defining a combustion chamber and including at least one liner formed of a ceramic matrix composite material and extending between a downstream end and an upstream end, the downstream end of the at least one liner defining an interface surface extending along the circumferential direction; and a seal member also formed of a ceramic matrix composite material and bonded to the interface surface of the at least one liner, the seal member defining a downstream surface for contacting an adjacent component to form a seal with the adjacent component.

Abstract: A combustor assembly for a gas turbine engine defining a radial direction and a circumferential direction includes a liner assembly at least partially defining a combustion chamber and including at least one liner formed of a ceramic matrix composite material and extending between a downstream end and an upstream end, the downstream end of the at least one liner defining an interface surface extending along the circumferential direction; and a seal member also formed of a ceramic matrix composite material and bonded to the interface surface of the at least one liner, the seal member defining a downstream surface for contacting an adjacent component to form a seal with the adjacent component.

Abstract: A saw apparatus includes a guide bar, a chain driver, and an endless cutting chain trained about the guide bar and the chain driver. The guide bar includes a first chain retention feature along at least a portion of its periphery, and the cutting chain includes a second chain retention feature configured to interact with the first chain retention feature such that movement of the second chain retention feature away from the guide bar is restricted. A timber-working device includes a frame, at least one pair of arms pivotally attached to the frame and configured to be controlled to grasp at least one tree, and the saw apparatus mounted to the frame.