Abstract: A computer system is provided that is programmed to receive data sets, a target metric, and a parameter that indicates a desired number of synthesized data sets. A memory stores instructions and data including the input data sets, the target metric, the parameter that indicates a desired number of synthesized data sets, and a neural network. The neural network includes a summing node and multiple processing nodes. At least one hardware processor is configured to perform operations where each processing node of a neural network weights input data set values, determines gating operations to select processing operations, and generates a node output by applying the gating operations to weighted input data set values. Weighted node outputs from the processing nodes produce a value for the target parameter. The neural network is iteratively trained by modifying the gating operations, the input weight values, and the node output weight value until the neural network converges.

Abstract: A computer system is provided that is programmed to select feature sets from a large number of features. Features for a set are selected based on metagradient information returned from a machine learning process that has been performed on an earlier selected feature set. The process can iterate until a selected feature set converges or otherwise meets or exceeds a given threshold.

Abstract: The present invention provides, in various embodiments, a miniature movable-beam laser objective configured to fit within the very small dimensions of a standard objective. This small, portable movable-laser source allows the beam to be directed at a computer-generated target or at the spot of a focused target-designator beam.

Abstract: Phosphorylation and dephosphorylation of MENA and MENA isoforms regulates the metastatic activity of cancer cells. Administration of a MENA kinase inhibitor results in significant reduction in the development of cancer metastasis in established and developing tumors. Administration of a MENA kinase inhibitor in conjunction with a tyrosine kinase inhibitor enhances efficacy of tyrosine kinase inhibitor therapy. Administration of a MENA kinase inhibitor in conjunction with anti-microtubule agent results in significant reduction in chemotherapy-induced tumor cell dissemination and enhances efficacy of anti-microtubule therapy.

Abstract: The present application concerns automated optimization, customization or production methods for the design of a solar photovoltaic array, involving one or more or all components in a photovoltaic array, in which the products include system designs, production drawings, permitting and construction drawings, layouts for the mechanical and electrical systems, bill of materials and financial return analyses of such a photovoltaic array.

Abstract: A receptacle including an electronic processor configured to receive information from an external load and determine, from the information, an operation profile of the external load. The electronic processor analyzes a present operation of the external load and discontinues power to the external load when a present operation of the external load differs from the operational profile.

Abstract: A continuous casting apparatus includes a first belt carried by a first upstream pulley and a first downstream pulley, a second belt carried by a second upstream pulley and a second downstream pulley, and a mold region defined by a first mold support section arranged behind the first belt and a second mold support section arranged behind the second belt. The first mold support section supports the first belt and defines a shape of the first belt in the mold region and the second mold support section supports the second belt and defines a shape of the second belt in the mold region. At least one of the first mold support section and the second mold support section includes a transition portion and a generally planar portion downstream from the transition portion. The transition portion has a variable radius configured to receive molten metal from a metal feeding device.

Abstract: A GUI driven computer implemented system prediction, comparison and selection of treatment modalities for surgical management of stone disease. A computer memory is configured to store regression weights for stone, patient, machine prediction variables for ESWL and URS for a percentile grouping calculation. A computer processer configured to compute a probability of success (Ps) and a probability of complications (Pc) for the ESWL and URS treatment modalities for the percentile grouping as a weighted combination of the regression weights and user input values for the prediction variables. The GUI includes a user selectable display space configured to display the stone, patient and machine prediction variables and receive and display user input of values for each prediction variable and a first results display space configured to display the computed Ps and Pc for each of ESWL and URS for the percentile grouping.

Abstract: Some embodiments comprise methods, systems, and compositions to promote, improve and/or increase neuronal differentiation, oligodendrocyte differentiation, or neurological outcome or function in a patient in need thereof. Some embodiments also comprise the administration a composition comprising a pharmaceutically effective amount of one or more of a group comprising microRNA-146a, a promoter of microRNA-146a expression, a microRNA-146a mimic, thymosin beta 4, and a phosphodiesterase 5 inhibitor to treat neurological conditions, disease, or injury in mammals, including in human beings.

Abstract: A laser assembly is provided which includes an objective assembly having an objective and a dichroic mirror, a collimating assembly having a collimating lens and a selectively displaceable mount, and a laser supply assembly having a laser source. The laser assembly can provide laser light through the collimating lens, which collimates the laser light into a collimated beam. The laser beam is preferably transmitted onto the dichroic mirror, which reflects the laser light through the objective along the optical path of the objective which converges into a focal point. Such a laser assembly preferably provides substantial control of the laser beam, for example, for micromanipulation of a sample.

Abstract: The present application concerns automated optimization, customization or production methods for the design of a solar photovoltaic array, involving one or more or all components in a photovoltaic array, in which the products include system designs, production drawings, permitting and construction drawings, layouts for the mechanical and electrical systems, bill of materials and financial return analyses of such a photovoltaic array.

Abstract: A novel composition and method of treating a wound is provided. The method comprises administering a therapeutically effective amount of periostin and/or CCN2 proteins to the wound.

Abstract: The present invention provides a method and system for using eye-safe infrared energy from a Class I laser to manipulate cells in culture. The laser energy produces one or more phase boundary propulsion events, which generate hydrodynamic forces sufficient to manipulate cells at the focal point.

Abstract: A modular laser objective for use with a microscope is provided. A mounting modular body permits the modular objective to be releasably mounted to the turret of a microscope. The objective has an optical axis that permits an image beam to be emitted through the objective toward the eyepiece of a microscope. The modular body supports a mirror positioned at an angle to the optical axis of the objective. A modular laser assembly is mounted on the modular body on a first side of the mirror for directing a laser beam toward the mirror so that the energy is reflected off the mirror and through the objective in a direction that is substantially aligned with the optical axis of the objective.

Abstract: An objective assembly for use with a microscope is provided. The objective has an optical axis that permits an image beam to be emitted through the objective toward the eyepiece of a microscope. A mirror is positioned at an angle to the optical axis of the objective. A laser assembly is positioned on a first side of the mirror for directing a laser beam toward said mirror so that the energy is reflected off the mirror and through the objective in a direction that is substantially aligned with the optical axis of the objective. An indicator assembly including a source of light is positioned with the light incident on the other side of the mirror to reflect a beam of light in a direction opposite to the direction of the laser beam to provide an optical representation at the eyepiece of a microscope of the position of the laser beam being emitted by the objective.

Abstract: A novel method of treating a wound is provided. The method comprises administering a therapeutically effective amount of periostin to the wound.

Abstract: The present invention provides a method and system for using eye-safe infrared energy from a Class I laser to manipulate cells in culture. The laser energy produces one or more phase boundary propulsion events, which generate hydrodynamic forces sufficient to manipulate cells at the focal point.

Abstract: The present invention provides a device of integrated neuronal cells interfaced with an electronic device and a method of producing the same.

Abstract: An antimicrobial film laminate assembly is disclosed. The assembly includes an antimicrobial film laminate having a first surface at least partially coated with an adhesive and an opposing second surface, the antimicrobial film laminate includes at least one antimicrobial compound, and a unitary backing positioned upon the first surface of the antimicrobial film laminate.

Abstract: The invention relates, generally, to a method of removing sharp edges from a microscope coverslip comprising grinding down the edges and polishing the edges The invention also relates to a device for determining cell motility comprising a slide, a coverslip, comprising at least one edge that has been smoothed and a chamber, created by the slide and the coverslip and which is tangential to the coverslip, such that motile cells entering the chamber are substantially undamaged. The invention also relates to a method for using the device to determine cell motility.