Patents by Inventor Douglas A. Holtzman
Douglas A. Holtzman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses
Publication number: 20060205034Abstract: The invention provides isolated nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.Type: ApplicationFiled: November 2, 2005Publication date: September 14, 2006Inventors: Christopher Fraser, Sean McCarthy, John Sharp, Thomas Barnes, Nicholas Wrighton, Charles Mackay, Kevin Leiby, Douglas Holtzman -
Publication number: 20060122373Abstract: The invention provides novel Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 polypeptides, proteins, and nucleic acid molecules. In addition to isolated, full-length Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 proteins, the invention further provides isolated Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 fusion proteins, antigenic peptides and anti-Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 antibodies. The invention also provides Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 or A259 gene has been introduced or disrupted.Type: ApplicationFiled: July 5, 2005Publication date: June 8, 2006Inventors: Sean McCarthy, David Gearing, Douglas Holtzman, Yang Pan, Samantha Busfield, Thomas Barnes, Charles Mackay, Jose Lora
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Publication number: 20060069246Abstract: The invention relates to the discovery and characterization of Tango-63d, Tango-63e genes and the polypeptides they encode. Tango-63d and Tango-63e are two novel polypeptides within the tumor necrosis factor (TNF) receptor superfamily.Type: ApplicationFiled: November 16, 2005Publication date: March 30, 2006Inventor: Douglas Holtzman
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Patent number: 6960651Abstract: The invention provides isolated nucleic acids encoding a variety of proteins and nucleic acids having diagnostic, preventive, therapeutic, and other uses. These nucleic acids and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.Type: GrantFiled: July 2, 2002Date of Patent: November 1, 2005Assignee: Millennium Pharmaceuticals, Inc.Inventors: Susan J. Kirst, Douglas A. Holtzman, Christopher C. Fraser, John D. Sharp, Thomas S. Barnes
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Publication number: 20050100940Abstract: Novel FDRG polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length FDRG proteins, the invention further provides isolated FDRG fusion proteins, antigenic peptides and anti-FDRG antibodies. The invention also provides FDRG nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a FDRG gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.Type: ApplicationFiled: September 30, 2004Publication date: May 12, 2005Inventors: Douglas Holtzman, Bruce Spiegelman, Clifford Yoon
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Publication number: 20050095633Abstract: The invention relates to regulators of fungal gene expression and their use in commercial and medical applications. More particularly, the invention relates to regulators of fungal genes involved in production of enzymes, secondary metabolites and other useful products, as well as to regulators of genes involved in fungal invasion. The invention provides novel regulators of fungal gene expression, and methods for using regulator genes in commercial and medical applications.Type: ApplicationFiled: September 28, 2004Publication date: May 5, 2005Inventors: Brian Cali, Douglas Holtzman, Jeffrey Silva, Joshua Trueheart, Lixin Zhang, Kevin Madden, G. Milne, Amir Sherman
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Publication number: 20050032172Abstract: Novel FTHMA-070 and T85 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length FTHMA-070 and T85 proteins, the invention further provides isolated FTHMA-070 and T85 fusion proteins, antigenic peptides and anti-FTHMA-070 and anti-T85 antibodies. The invention also provides FTHMA-070 and T85 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a FTHMA-070 gene or T85 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.Type: ApplicationFiled: July 21, 2004Publication date: February 10, 2005Inventors: Sean McCarthy, Douglas Holtzman
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Publication number: 20050019810Abstract: The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.Type: ApplicationFiled: July 28, 2004Publication date: January 27, 2005Inventors: Douglas Holtzman, Andrew Goodearl, Sean McCarthy
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Publication number: 20040253605Abstract: The invention relates to Tango-71, Tango-79, and Tango-81 polypeptides, nucleic acid molecules encoding Tango-71, Tango-79, and Tango-81, and uses thereof. The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided.Type: ApplicationFiled: November 20, 2003Publication date: December 16, 2004Applicant: Millennium Pharmaceuticals, Inc.Inventors: Sean A. McCarthy, Douglas A. Holtzman, Andrew D.J. Goodearl
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Patent number: 6806082Abstract: The invention relates to regulators of fungal gene expression and their use in commercial and medical applications. More particularly, the invention relates to regulators of fungal genes involved in production of enzymes, secondary metabolites and other useful products, as well as to regulators of genes involved in fungal invasion. The invention provides novel regulators of fungal gene expression, and methods for using regulator genes in commercial and medical applications.Type: GrantFiled: December 22, 2001Date of Patent: October 19, 2004Assignee: Microbia, Inc.Inventors: Brian M. Cali, Douglas Holtzman, Kevin T. Madden, G. Todd Milne, Amir Sherman, Jeffrey C. Silva, Joshua Trueheart, Lixin Zhang
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Publication number: 20040176296Abstract: Novel ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST proteins, the invention further provides isolated ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST fusion proteins, antigenic peptides and anti-ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST antibodies. The invention also provides ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which an ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.Type: ApplicationFiled: March 22, 2004Publication date: September 9, 2004Applicant: Millennium Pharmaceuticals, Inc.Inventors: Douglas A. Holtzman, Sean A. McCarthy, Kyle J. MacBeth, Samantha J. Busfield, Yang Pan, David White, Mehran M. Khodadoust, Wei Gu
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Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses
Publication number: 20040121396Abstract: The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.Type: ApplicationFiled: December 19, 2003Publication date: June 24, 2004Applicant: Millennium Pharmaceuticals, Inc.Inventors: Christopher C. Fraser, Thomas M. Barnes, John D. Sharp, Susan J. Kirst, Paul S. Myers, Kevin R. Leiby, Douglas A. Holtzman, Sean A. McCarthy, Nicholas Wrighton, Charles R. MacKay, Andrew D.J. Goodearl -
Publication number: 20030175733Abstract: The invention provides isolated nucleic acids encoding a variety of proteins and nucleic acids having diagnostic, preventive, therapeutic, and other uses. These nucleic acids and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.Type: ApplicationFiled: July 2, 2002Publication date: September 18, 2003Applicant: MILLENNIUM PHARMACEUTICALS, INC.Inventors: Susan J. Kirst, Douglas A. Holtzman, Christopher C. Fraser, John D. Sharp, Thomas S. Barnes
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Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses
Publication number: 20030170621Abstract: The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.Type: ApplicationFiled: January 19, 2001Publication date: September 11, 2003Inventors: Sean A. McCarthy, Christopher C. Fraser, John D. Sharp, Thomas M. Barnes, Susan J. Kirst, Paul S. Myers, Nicholas Wrighton, Andrew D.J. Goodearl, Douglas A. Holtzman, Mehran Khodadoust -
Publication number: 20030143632Abstract: The invention relates to Tango-73, Tango-74, Tango-76, Tango-78, and Tango-83 polypeptides, nucleic acid molecules encoding Tango-73, Tango-74, Tango-76, Tango-78, and Tango-83, and uses thereof. The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided.Type: ApplicationFiled: February 12, 2003Publication date: July 31, 2003Applicant: Millennium Pharmaceuticals, Inc.Inventors: Douglas A. Holtzman, Andrew D.J. Goodearl, Sean A. McCarthy
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Publication number: 20030125540Abstract: The invention relates to the discovery and characterization of several genes and the polypeptides they encode: thymotaxin (Tango-45), Tango-63d, Tango-63e, Tango-67, and huchordin (Tango-66). Thymotaxin is a new member of the C—C family of chemokines. Tango-63d and Tango-63e are two novel polypeptides within the tumor necrosis factor (TNF) receptor superfamily. Tango-67 is related to a number of growth factors. particularly members of the connective tissue growth factor family. Huchordin is related to chordin, a known protein that is involved in the induction of twinned axes, can completely rescue axial development in ventralized embryos, is a potent dorsalizing factor, and plays a crucial role in regulating cell-cell interactions in the organizing centers of head, trunk, and tail development.Type: ApplicationFiled: December 6, 2002Publication date: July 3, 2003Applicant: Millennium Pharmaceuticals, Inc.Inventors: Douglas A. Holtzman, David P. Gearing, Yang Pan
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Publication number: 20030104447Abstract: The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.Type: ApplicationFiled: October 11, 2002Publication date: June 5, 2003Applicant: Millennium Pharmaceuticals, Inc.Inventors: Douglas A. Holtzman, Andrew D.J. Goodearl, Sean A. McCarthy
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Publication number: 20030099994Abstract: Novel FDRG polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length FDRG proteins, the invention further provides isolated FDRG fusion proteins, antigenic peptides and anti-FDRG antibodies. The invention also provides FDRG nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a FDRG gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.Type: ApplicationFiled: October 3, 2002Publication date: May 29, 2003Applicant: Millennium Pharamceuticals, Inc.Inventors: Douglas A. Holtzman, Bruce M. Spiegelman, Clifford Hyunsuk Yoon
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Publication number: 20030082677Abstract: Novel EDIRF, MTR-1, LSP-1, TAP-1, and PA-I polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length EDIRF, MTR-1, LSP-1, TAP-1, and PA-I proteins, the invention further provides isolated EDIRF, MTR-1, LSP-1, TAP-1, and PA-I fusion proteins, antigenic peptides and anti-EDIRF, MTR-1, LSP-1, TAP-1, and PA-I antibodies. The invention also provides EDIRF, MTR-1, LSP-1, TAP-1, and PA-I nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which an EDIRF, MTR-1, LSP-1, TAP-1, and PA-I gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.Type: ApplicationFiled: January 30, 2001Publication date: May 1, 2003Inventors: Douglas A. Holtzman, Yang Pan, Sean A. McCarthy, David P. Gearing
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Publication number: 20030082586Abstract: The invention provides isolated nucleic acids encoding a variety of proteins and nucleic acids having diagnostic, preventive, therapeutic, and other uses. These nucleic acids and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.Type: ApplicationFiled: July 2, 2002Publication date: May 1, 2003Applicant: MILLENNIUM PHARMACEUTICALS, INC.Inventors: Susan J. Kirst, Douglas A. Holtzman, Christopher C. Fraser, John D. Sharp, Thomas S. Barnes