Patents by Inventor Douglas Alexander Brooks

Douglas Alexander Brooks has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multiplex screening for lysosomal storage disorders (LSDS)
    Patent number: 8735173
    Abstract: A novel protein profiling method of testing for Lysosomal Storage Diseases (“LSD”) using discovered normalized lysosomal fingerprint patterns. The fingerprint patterns reveal the health of lysosomal organelles, specific LSD, and clinical severity. Multiplexing bead technology for simultaneous screening of multiple LSD and normalizing measured enzyme activity or protein levels against other lysosomal proteins, enzymes, or enzyme activities. Compounds, reagents, and methods for identifying and quantifying multiple target enzymes and proteins.
    Type: Grant
    Filed: March 28, 2012
    Date of Patent: May 27, 2014
    Assignee: Women's and Children's Hospital
    Inventors: Peter John Meikle, John Joseph Hopwood, Douglas Alexander Brooks, Caroline Dean
  • MULTIPLEX SCREENING FOR LYSOSOMAL STORAGE DISORDERS (LSDS)
    Publication number: 20120184050
    Abstract: A novel protein profiling method of testing for Lysosomal Storage Diseases (“LSD”) using discovered normalized lysosomal fingerprint patterns. The fingerprint patterns reveal the health of lysosomal organelles, specific LSD, and clinical severity. Multiplexing bead technology for simultaneous screening of multiple LSD and normalizing measured enzyme activity or protein levels against other lysosomal proteins, enzymes, or enzyme activities. Compounds, reagents, and methods for identifying and quantifying multiple target enzymes and proteins.
    Type: Application
    Filed: March 28, 2012
    Publication date: July 19, 2012
    Applicant: WOMEN'S AND CHILDREN'S HOSPITAL
    Inventors: Peter John Meikle, John Joseph Hopwood, Douglas Alexander Brooks, Caroline Dean
  • Multiplex screening for lysosomal storage disorders (LSDs)
    Patent number: 8173443
    Abstract: A novel protein profiling method of testing for Lysosomal Storage Diseases (“LSD”) using discovered normalized lysosomal fingerprint patterns. The fingerprint patterns reveal the health of lysosomal organelles, specific LSD, and clinical severity Multiplexing bead technology for simultaneous screening of multiple LSD and normalizing measured enzyme activity or protein levels against other lysosomal proteins, enzymes, or enzyme activities. Compounds, reagents, and methods for identifying and quantifying multiple target enzymes and proteins.
    Type: Grant
    Filed: March 31, 2004
    Date of Patent: May 8, 2012
    Assignee: Women's and Children's Hospital
    Inventors: Peter John Meikle, John Joseph Hopwood, Douglas Alexander Brooks, Caroline Dean
  • Multiplex-bead complex for determination of lysosomal storage disorders
    Patent number: 7615224
    Abstract: Multiplexing bead technology is used for simultaneous screening of multiple LSD and normalizing measured enzyme activity or protein levels against other lysosomal proteins, enzymes, or enzyme activities. Diagnostic compositions include microspheres conjugated to purified antibodies that specifically bind LSD target antigens: saposin, LAMP-1, ?-iduronidase, ?-glucosidase, ?-glucosidase, 2-sulphatase, 4-sulphatase, ?-galactosidase, sphingomyelinase, 3-sulphatase or sulphamidase. The target antigens are naturally present in biological fluids or tissues of either LSD or non-LSD patients.
    Type: Grant
    Filed: December 1, 2005
    Date of Patent: November 10, 2009
    Assignee: Women's and Children's Hospital
    Inventors: Peter John Meikle, John Joseph Hopwood, Douglas Alexander Brooks, Caroline Dean