Abstract: The present invention provides methods and systems for organizing complex and disparate data. More specifically, the present invention provides methods and systems for organizing complex and disparate data into coherent data sets. Coherent data sets resulting from the methods and systems of the present invention serve as models for biological systems. Methods and systems for integrating data and creating coherent data sets are useful for numerous biological applications, such as, for example, determining gene function, identifying and validating drug and pesticide targets, identifying and validating drug and pesticide candidate compounds, profiling drug and pesticide compounds, producing a compilation of health or wellness profiles, determining compound site(s) of action, identifying unknown samples, and numerous other applications in the agricultural, pharmaceutical, forensic, and biotechnology industries.

Abstract: The present invention provides methods and systems for organizing complex and disparate data. More specifically, the present invention provides methods and systems for organizing complex and disparate data into coherent data sets. Coherent data sets resulting from the methods and systems of the present invention serve as models for biological systems. Methods and systems for integrating data and creating coherent data sets are useful for numerous biological applications, such as, for example, determining gene function, identifying and validating drug and pesticide targets, identifying and validating drug and pesticide candidate compounds, profiling drug and pesticide compounds, producing a compilation of health or wellness profiles, determining compound site(s) of action, identifying unknown samples, and numerous other applications in the agricultural, pharmaceutical, forensic, and biotechnology industries.

Abstract: The present invention provides methods and systems for organizing complex and disparate data. More specifically, the present invention provides methods and systems for organizing complex and disparate data into coherent data sets. Coherent data sets resulting from the methods and systems of the present invention serve as models for biological systems. Methods and systems for integrating data and creating coherent data sets are useful for numerous biological applications, such as, for example, determining gene function, identifying and validating drug and pesticide targets, identifying and validating drug and pesticide candidate compounds, profiling drug and pesticide compounds, producing a compilation of health or wellness profiles, determining compound site(s) of action, identifying unknown samples, and numerous other applications in the agricultural, pharmaceutical, forensic, and biotechnology industries.

Abstract: The present invention provides methods and systems for organizing complex and disparate data. More specifically, the present invention provides methods and systems for organizing complex and disparate data into coherent data sets. Coherent data sets resulting from the methods and systems of the present invention serve as models for biological systems. Methods and systems for integrating data and creating coherent data sets are useful for numerous biological applications, such as, for example, determining gene function, identifying and validating drug and pesticide targets, identifying and validating drug and pesticide candidate compounds, profiling drug and pesticide compounds, producing a compilation of health or wellness profiles, determining compound site(s) of action, identifying unknown samples, and numerous other applications in the agricultural, pharmaceutical, forensic, and biotechnology industries.

Abstract: The present invention provides methods and systems for organizing complex and disparate data. More specifically, the present invention provides methods and systems for organizing complex and disparate data into coherent data sets. Coherent data sets resulting from the methods and systems of the present invention serve as models for biological systems. Methods and systems for integrating data and creating coherent data sets are useful for numerous biological applications, such as, for example, determining gene function, identifying and validating drug and pesticide targets, identifying and validating drug and pesticide candidate compounds, profiling drug and pesticide compounds, producing a compilation of health or wellness profiles, determining compound site(s) of action, identifying unknown samples, and numerous other applications in the agricultural, pharmaceutical, forensic, and biotechnology industries.

Abstract: The present inventors have discovered that 1-Aminocyclopropane-1-Carboxylate Oxidase (ACC) is essential for plant growth. Specifically, the inhibition of ACC gene expression in plant seedlings results in reduced and severely stunted growth, and chlorosis. Thus, ACC can be used as a target for the identification of herbicides. Accordingly, the present invention provides methods for the identification of compounds that inhibit ACC expression or activity, comprising: contacting a compound with an ACC and detecting the presence and/or absence of binding between said compound and said an ACC, or detecting a decrease in ACC expression or activity. The methods of the invention are useful for the identification of herbicides.

Abstract: The present inventors have discovered that Thioredoxin (TRX) is essential for plant growth. Specifically, the inhibition of TRX gene expression in plant seedlings results in seedling deformities, reduced and severely stunted growth, and chlorosis. Thus, TRX can be used as a target for the identification of herbicides. Accordingly, the present invention provides methods for the identification of compounds that inhibit TRX expression or activity, comprising: contacting a compound with a TRX and detecting the presence and/or absence of binding between said compound and said a TRX, or detecting a decrease in TRX expression or activity. The methods of the invention are useful for the identification of herbicides.

Abstract: The present inventors have discovered that the polypeptide encoded by the cDNA of SEQ ID NO:1 is essential for plant growth. Thus, this polypeptide can be used as a target for the identification of herbicides. Accordingly, the present invention provides methods for the identification of compounds that inhibit the expression or activity of the polypeptide encoded by SEQ ID NO:2. Such compounds have use as herbicides. In addition, methods and compositions for modulating plant growth and development are provided.

Abstract: The present inventors have discovered that pyruvate orthophosphate dikinase (PPDK) is essential for plant growth. Specifically, the inhibition PPDK gene expression in plant seedlings results in significant developmental abnormalities, including abnormal cotyledon development, abnormal or aborted primary leaf development and significantly reduced growth. Thus, PPDK can be used as a target for the identification of herbicides. Accordingly, the present invention provides methods for the identification of compounds that inhibit PPDK expression or activity, comprising: contacting a compound with a PPDK and detecting the presence and/or absence of binding between said compound and said a PPDK, or detecting a decrease in PPDK expression or activity. The methods of the invention are useful for the identification of herbicides.

Abstract: The present inventors have discovered that the germin-like polypeptides set forth in SEQ ID NO: 2, 4, 6, 8, and 10 are essential for plant growth. Thus, these polypeptides can be used as targets for the identification of herbicides. Accordingly, the present invention provides methods for the identification of compounds that inhibit the expression or activity of the polypeptides encoded by SEQ ID NO: 2, 4, 6, 8 or 10. Such compounds have use as herbicides. In addition, methods and compositions for modulating plant growth and development are provided.

Abstract: The present invention discloses that 2′-hydroxyisoflavone reductase (IFR) is essential for plant growth. Specifically, the inhibition of IFR gene expression in plant seedlings results in seedlings that fail to produce roots or leaves. Thus, IFR is a useful target for the identification of herbicides. Accordingly, the present invention provides compositions and methods for the identification of compounds that inhibit IFR expression or activity.