Patents by Inventor Douglas C. Covert

Douglas C. Covert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7745176
    Abstract: The expression vectors and methods using an E. coli expression system for the large scale production of IL-21 are described. The vectors utilize the IL-21 coding sequence with specific changes in nucleotides in order to optimize codons and mRNA secondary structure for translation in E. coli. Using the expression vectors, the IL-21 gene was produced in E. coli to a level of greater than 1 g/L in fed batch fermentation. Also included are OmpT deficient E. coli strains transformed with an IL-21 expression vector.
    Type: Grant
    Filed: October 5, 2006
    Date of Patent: June 29, 2010
    Assignee: ZymoGenetics, Inc.
    Inventors: Bruce L. Zamost, Douglas C. Covert
  • Patent number: 7250274
    Abstract: The expression vectors and methods using an E. coli expression system for the large scale production of IL-21 are described. The vectors utilize the IL-21 coding sequence with specific changes in nucleotides in order to optimize codons and mRNA secondary structure for translation in E. coli. Using the expression vectors, the IL-21 gene was produced in E. coli to a level of greater than 1 g/L in fed batch fermentation. Also included are OmpT deficient E. coli strains transformed with an IL-21 expression vector.
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: July 31, 2007
    Assignee: ZymoGenetics, Inc.
    Inventors: Chung Chan, Bruce L. Zamost, Douglas C. Covert, Hong Y. Liu, Karen S. De Jongh, Jeffrey D. Meyer, Susan D. Holderman
  • Patent number: 4026040
    Abstract: An educational kit for aiding a student in the understanding of the induction of electrical current and the basic functions of inductors in electrical circuits is disclosed. The educational kit includes an instructional device, preferably in the form of an audiovisual instructional device, and a simulator board that enables a student to use magnets to induce measurable current and also enables a student to measure the effects of inductors in active electrical circuits that the student designs and assembles on the simulator board.
    Type: Grant
    Filed: July 26, 1973
    Date of Patent: May 31, 1977
    Assignee: Xerox Corporation
    Inventors: Charles G. Valentine, Douglas C. Covert