Patents by Inventor Douglas C. Harnish

Douglas C. Harnish has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Assay to identify estrogen receptor dependent ligands that regulate the hepatic lipase promoter
    Patent number: 7521199
    Abstract: The present invention relates to an assay system and method for testing compounds for their ability to regulate the hepatic lipase (HL) promoter. In particular, the invention relates to the identification of estrogen receptor ligands having this activity. Compounds that inhibit HL promoter activity are useful as leads, or on their own, to develop therapeutics in the prevention of heart disease.
    Type: Grant
    Filed: June 21, 2006
    Date of Patent: April 21, 2009
    Assignee: Wyeth
    Inventors: Douglas C. Harnish, Marshall S. Scicchitano, Sotirios K. Karathanasis, Chu-Lai Hsiao
  • Assay to identify estrogen receptor dependent ligands that regulate the hepatic lipase promoter
    Patent number: 7094559
    Abstract: The present invention relates to an assay system and method for testing compounds for their ability to regulate the hepatic lipase (HL) promoter. In particular, the invention relates to the identification of estrogen receptor ligands having this activity. Compounds that inhibit HL promoter activity are useful as leads, or on their own, to develop therapeutics in the prevention of heart disease.
    Type: Grant
    Filed: August 8, 2001
    Date of Patent: August 22, 2006
    Assignee: Wyeth
    Inventors: Douglas C. Harnish, Marshall S. Scicchitano, Sotirios K. Karathanasis, Chu-Lai Hsiao
  • Use of estrogen receptor alpha modulators for the treatment of multiple sclerosis
    Publication number: 20040167112
    Abstract: The present invention provides methods of treating an autoimmune pathology in a mammal, comprising administering an agent with estrogen receptor &agr; agonist activity in particular a selective estrogen receptor modulator, to the mammal in an amount sufficient to decrease production of TH-1 and/or TH-2 cytokines. Also provided is a method of selecting compounds useful for the treatment of multiple sclerosis, comprising selecting a compound which has estrogen receptor &agr; agonist activity.
    Type: Application
    Filed: January 5, 2004
    Publication date: August 26, 2004
    Applicant: Wyeth
    Inventors: M. Merle Elloso, Robert Mitchell, Douglas C. Harnish, Steven J. Adelman