Patents by Inventor Douglas C. Hixson

Douglas C. Hixson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation and composition of inter-alpha inhibitor proteins from human plasma for therapeutic use
    Patent number: 7932365
    Abstract: The invention relates to Inter-alpha inhibitor proteins (I?Ip). The invention further relates to processes for purification of I?Ip compositions and their use for treatment of human diseases such as sepsis and septic shock, rheumatoid arthritis, cancer and infectious diseases.
    Type: Grant
    Filed: November 5, 2004
    Date of Patent: April 26, 2011
    Assignee: Pro Thera Biologics, LLC
    Inventors: Yow-Pin Lim, Djuro Josic, Douglas C. Hixson
  • Inter-alpha-trypsin inhibitor as a marker for sepsis
    Patent number: 6660482
    Abstract: The invention provides a method of diagnosing sepsis in a mammal by contacting a bodily fluid from the mammal with a ligand which binds to an inter-alpha trypsin inhibitor (ITI) polypeptide under conditions sufficient to form an ITI-ligand complex and detecting the complex.
    Type: Grant
    Filed: February 28, 2000
    Date of Patent: December 9, 2003
    Assignee: Rhode Island Hospital
    Inventors: Yow-Pin Lim, Douglas C. Hixson
  • Methods for detecting cancer of the central nervous system
    Patent number: 6489128
    Abstract: A method for diagnosing a tumor in the central nervous system of a mammal is carried out by contacting a bodily fluid from the mammal with a ligand which binds to inter-alpha trypsin inhibitor.
    Type: Grant
    Filed: January 24, 2000
    Date of Patent: December 3, 2002
    Assignee: Rhode Island Hospital, A Lifespan Partner
    Inventors: Yow-Pin Lim, Douglas C. Hixson
  • Preparative electrophoresis device and method
    Patent number: 5284559
    Abstract: A preparative electrophoresis device having a pair of spaced apart plates, a pre-cast electrophoretic gel between the plates, and a semipermeable membrane sealably connected to ends of the plates to define with the plates a collection channel for receiving molecules that have traveled through the gel. Also disclosed are close spacing (less than 2.0 mm) of the plates, an inlet tube and an outlet tube connected to the two plates and communicating with opposite ends of the collection channel, an elongated divider between the plates to divide the gel into a purification region and an indicating region that is not as wide as the purification region and receives marker molecules of known molecular weight to indicate the location in the indicating region of molecules of interest, and pumping electrophoretic buffer into the collection channel at the same rate that it is pumped out.
    Type: Grant
    Filed: June 16, 1992
    Date of Patent: February 8, 1994
    Assignee: Rhode Island Hospital
    Inventors: Yow-Pin Lim, Douglas C. Hixson
  • Preparation and composition of inter-alpha inhibitor proteins from human plasma for therapeutic use
    Patent number: RE47972
    Abstract: The invention relates to Inter-alpha inhibitor proteins (I?Ip). The invention further relates to processes for purification of I?Ip compositions and their use for treatment of human diseases such as sepsis and septic shock, rheumatoid arthritis, cancer and infectious diseases.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: May 5, 2020
    Assignee: ProThera Biologics, Inc.
    Inventors: Yow-Pin Lim, Djuro Josic, Douglas C. Hixson