Abstract: The present invention provides a compound of the formula: a pharmaceutically acceptable salt or a prodrug thereof, where R1, R2, R3, R4, R5, R6, R7, R8, R9, Y, Z1, m, n, and p are as defined herein. The present invention also provides compositions comprising, methods for using, and methods for preparing Compound of Formula I.

Abstract: A system (799) and method for continuous web sublimate dye transfer printing uses platens (800, 805) which also act as air bearings. The platens are heated by resistive heating elements ( 825 ) or other means. A sandwich of air-impermeable dye-image donor tissue (1100), the medium to be printed (1140), and air-impermeable backup tissue (1115) are fed through the heated air bearing where the dye transfer step occurs. The tissues and medium are supplied on supply rolls (1105, 1120, and 1145) which are restrained by braking mechanisms (not shown). Take-up rolls (1110, 1160, and 1135) are driven by motor-and-clutch mechanisms (not shown) so that the tissues and medium to be printed move through the heated region between the platens without sliding past one-another. The platens are forced together on either side of the tissue-medium sandwich with sufficient pressure to prevent the sublimate dye gas from migrating sideways through the medium being printed.

Abstract: The present invention provides for dynamically determining a ratio of forwarded packets to injected packets to be transmitted in a bus ring. At least one forwarded packet is received into a first queue. An injected packet is received into a second queue. A determination, or snapshot, of the number of forwarded packets in the first queue due to the presence of the injected packet in the second queue is triggered. Packets corresponding to the snapshot are transmitted. After the packets are transmitted, if there is another injected packet stored in the second queue, another snapshot is performed. Packets corresponding to this snapshot are transmitted, and so on.

Abstract: A method, system, and computer readable medium including instructions for evaluating and promoting a direct mail marketing campaign includes receiving the cost associated with the campaign and financial information for the campaign. The return on investment is calculated for the direct mail marketing campaign based on the cost and financial information. The return on investment is utilized to evaluate and promote the campaign.

Abstract: Individual employees are permitted to be individuals and plan their work as individuals. Individuals are only asked to plan their work within a limited tasking horizon. Employees track their progress using verbs that are designed to capture the reasons behind positive and negative predictive ability. Verbs are analyzed and expected predictive error, also know as risk, is calculated. Once verbs are captured they can be analyzed for ways to improve predictive ability. In addition, the risk can be factored into the initial planning stage so as to include an expected predictive error in the initial planning. The cost, effort, churn and risk values of projects are then illustrated in a comparison form with historical limitations from past similar projects.

Abstract: A method and apparatus are provided for efficiently managing limited resources is a given computer system. The system utilizes a token manager that assigns tokens to groups of associated requestors. The tokens are then utilized by the requesters to occupy the given resource. The allocation of these tokens, thus, prevents such problems as denial of service due to a lack of available resources.

Abstract: A method and system that increases the throughput of a mailing machine by continuously computing indicia prior to and during mail processing is provided. The indicia generation process is divided into two distinct parts, cryptographic calculation and funds committal/printing. Indicium data are continuously computed, asynchronously with the printing of the indicia, and stored in a buffer until needed. This enables several indicium data to be computed and stored prior to processing of a mail piece by the mailing machine. Prior to printing an indicium on a mail piece, the funds for the indicium are accounted for by updating the registers of the mailing machine. Since a number of indicium data may be pre-computed prior to the start of processing the mail through the mailing machine, the throughput of the mailing machine can be increased.

Abstract: Individual employees arc permitted to be individuals and plan their work as individuals. Individuals are only asked to plan their work within a limited tasking horizon. Employees track their progress using verbs that are designed to capture the reasons behind positive and negative predictive ability. Verbs are analyzed and expected predictive error, also know as risk, is calculated. Once verbs arc captured they can be analyzed for ways to improve predictive ability. In addition, the risk can be factored into the initial planning stage so as to include an expected predictive error in the initial planning. The cost, effort, churn and risk values of projects are then illustrated in a comparison form with historical limitations from past similar projects.

Abstract: A method for maintaining cache coherency for a multi-node system using a specialized bridge which allows for fewer forward progress dependencies. A look-up of a local node directory is performed if a request received at a multi-node bridge of the local node is a system request. If a directory entry indicates that data specified in the request has a local owner or local destination, the request is forwarded to the local node. If the local node determines that the request is a local request, a look-up of the local node directory is performed. If the directory entry indicates that data specified in the request has a local owner and local destination, the coherency of the data on the local node is resolved and a transfer of the request data is performed if required. Otherwise, the request is forwarded to all remote nodes in the multi-node system.

Abstract: A method for maintaining cache coherency for a multi-node system using a specialized bridge which allows for fewer forward progress dependencies. A local node makes a determination whether a request is a local or system request. If the request is a local request, a look-up of a directory in the local node is performed. If an entry in the directory of the local node indicates that data in the request does not have a remote owner and that the request does not have a remote destination, the coherency of the data is resolved on the local node, and a transfer of the data specified in the request is performed if required and if the request is a local request. If the entry indicates that the data has a remote owner or that the request has a remote destination, the request is forwarded to all remote nodes in the multi-node system.

Abstract: A tamper protected printed circuit board assembly including a printed circuit board and a partially enveloping tamper wrap covering the entirety of the top surface of the printed circuit board and a first portion of the bottom surface of the printed circuit board, wherein a second portion of the bottom surface of the printed circuit board is not covered by the tamper wrap is provided. The printed circuit board includes two security trace layers each having two security traces thereon, preferably in a serpentine pattern. The tamper wrap and the security traces together cover and prevent tampering with the electronic circuitry of the printed circuit board.

Abstract: In one aspect of a first embodiment, a rotary pad printing system comprises a controller (400), an image source (498) that provides an image to the controller, a rotary pad (200) that is urged to rotate by a first motive source, a monochrome or color ink source or applicator such as an inkjet (215), and an actuator (235, 730). The system has the ability to print onto a flat or uneven surface (410). The controller actuates the ink source, causing it to deposit an ink image (202) onto a rotating pad wheel (200). As the surface moves, the wheel is held in contact with the surface by an actuator (235) or arm (705). As the wheel turns in contact with the surface, the ink image comes into contact with the surface and transfers to it, thereby printing the ink image onto a flat or uneven surface.

Abstract: Techniques for validating the integrity of a data communications link are provided. By executing error correction/detection calculations, such as CRC calculations, in a pipelined manner, logic may be distributed over multiple machine cycles.

Abstract: A system and method for flexible multiple protocols are presented. A device's logical layer may be dynamically configured on a per interface basis to communicate with external devices in a coherent or a non-coherent mode. In coherent mode, commands such as coherency protocol, system commands, and snoop response pass from the device's internal system bus to an external device, thereby creating a logical extension of the devices internal system bus. In non-coherent mode, the input-output bus unit receives commands from the internal system bus and generates non-coherent input-output commands, which are eventually received by an external device.

Abstract: In a first aspect, a first method of testing a link between a first chip and a second chip is provided. The first method includes the steps of, while operating in a test mode, (1) transmitting test data of sufficient length to enable exercising of worst case transitions from the first chip to the second chip via the link; and (2) performing cyclic redundancy checking (CRC) on the test data to test the link. Numerous other aspects are provided.

Abstract: A multi-analyte calibration solution having known amounts of sodium carbonate, ammonium bicarbonate, and ethyl alcohol, with pH adjusted within a range between about 7.8 and 8.4.

Abstract: A modular shoe separates into components. The components may be interchangeable to provide versatility without requiring a large number of single use shoes. Each shoe component may also be collapsible to provide for convenient packing in a travel bag or other location where space is limited.

Abstract: A rotary pad printing system comprises a compressible pad wheel (105), one or more inkjet or other image applicator heads (400), optional treatment stations (500), a shaft encoder (535), a control unit (540), and an image source (565). The image applicator heads apply an image to the wheel and the treatment stations can supply treatments such as heat, gas, light, overcoats, and undercoats. The image is then transferred to a receiving surface (532). An optional cleaning station (510) cleans the rotary pad prior to application of the next or a continuous image. Each image can be different and can be applied to a moving surface. Since the rotary pad can continuously receive updated image information, the area printed can range from a single pixel to an image of indefinite length. In an alternative embodiment, a domed pad is used. In another alternative embodiment, a flexible belt (1000) is used instead of a rotary wheel. In another alternative embodiment, a segmented pad (2205) is used.

Abstract: A logistics system manages the shipments of goods supplied from a plurality of different shippers by a plurality of carriers. It has a variety of modules integrated with each other to perform various functionalities. For example, it may have a purchasing module evaluating proposals by shippers for respective shipments of goods and awarding contracts for the shipments to the plurality of carriers. It may have an optimization module analyzing the proposals and informing the purchasing module if an opportunity exists for at least some of the shipments to be consolidated, in which case at least one contract awarded by the purchasing module is for a consolidated group of the shipments. It may have a contract administration module maintaining information relating to the status of proposals received and contracts awarded by the purchasing module. It may have a scheduling module scheduling shipments according to the awarded contracts.

Abstract: In a first aspect, a first method of testing a link between a first chip and a second chip is provided. The first method includes the steps of, while operating in a test mode, (1) transmitting test data of sufficient length to enable exercising of worst case transitions from the first chip to the second chip via the link; and (2) performing cyclic redundancy checking (CRC) on the test data to test the link. Numerous other aspects are provided.