Abstract: The present invention relates to novel Amido-Substituted Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R7, and R8 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Heterocycle Compound, and methods of using the Amido-Substituted Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.

Abstract: In a first aspect of the invention, the three-way ring puzzle has a rectangular housing with a first and second opposite sides. A first series of stems extends from the first side, and a second series of stems extends from the second side. Each stem has an eyelet on its extremity outside the housing and a wire loop is loosely mounted in this eyelet. Each of the stems in the first series aligns with and is joined inside the housing to one of the stems in the second series. A first and second elongated wire bands are respectively mounted in the wire loops on the first and the second series of stems. In another aspect of the present invention, the housing has a cylindrical shape, the stems extend diametrically through the housing and each of the elongated wire bands has a curved shape.

Abstract: A button attaching device for attaching a button having four holes to a layer of material includes a holder having a front end and a rear end, four rodless fastener dispensing needles projecting out from the front end of the holder and two fasteners, each having a foot at each end of an elongated filament. Each foot is removably mounted on one of the rodless fastener dispensing needles. A cover is removably mounted on the front end of the holder and includes an anvil. In use, the cover is removed from the holder and the layer of material placed on the cover over the anvil. The button is then placed over the layer of material. The holder is then pushed in the direction of the cover so that the needles and fastener feet extend through the holes in the button and through the layer of material, with the tips of the needles striking the anvil. The tension on the filaments of the fasteners causes the feet to pop out from the needles.

Abstract: A button attaching device for attaching a button to a layer of material includes a C-frame having a top portion, an intermediate portion and a bottom portion. A plurality of needle block assemblies are disposed inside the top portion of the C-frame in a stack. A manually operable plunger is slidably mounted on the top portion of the C-frame for up and down movement and positioned to receive and move downward the lowermost needle block assembly in the stack. Each needle block assembly includes a block of elastomeric material, a pair of rodless fastener dispensing needles and a fastener of the type having a foot at each end of a filament. Each foot is removably mounted on one of the pair of rodless fastener dispensing needles. In use, a button and a layer of material to which the button is to be attached are positioned on top of an anvil formed on the bottom portion of the C-frame.

Abstract: A button attaching device includes a top member and a bottom member which are hingedly connected together, the bottom member including an anvil. The button attaching device further includes a needle block assembly mounted on the top member. The needle block assembly includes a block of material, a pair of rodless fastener dispensing needles and a fastener. The fastener is shaped to include a foot formed at each end of a filament which can be removably mounted on one of the pair of rodless fastener dispensing needles. In one embodiment of the present invention, the needle block assembly is removably mounted on the top member and is sized and shaped so as to fit within a needle block assembly storage compartment formed in the bottom member. In another embodiment of the present invention, a plurality of needle block assemblies are interconnected to form a needle block carousel which is rotably mounted within a hollowed portion formed in the top member.

Abstract: Aerostats and aquastats are described in which a sealed envelope of flexible material impervious to the passage of gas therethrough is mounted on a flexible frame forming a permanent part of the device and which can be caused to expand the envelope after it has been wholly or very substantially evacuated of internal gas, thereby setting up a vacuum or partial vacuum condition in the envelope. In the case of a partial vacuum, the gas at reduced pressure may be hydrogen or helium. The lift or buoyancy of the device may be controlled when in use by altering the volume of the envelope by adjusting the shape of the frame by acting mechanism carried by the device. The frame may comprise flexible rods connected together at opposite ends so that by forcing the opposite ends of the rods towards one another they are bowed outwards distending the envelope towards a globular form.