Abstract: The present invention relates to novel Amido-Substituted Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.

Abstract: The present invention relates to novel Amido-Substituted Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R7, and R8 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Heterocycle Compound, and methods of using the Amido-Substituted Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.

Abstract: The present invention relates to novel Fused Bicyclic Pyrazole Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, and R6 are as defined herein. The present invention also relates to compositions comprising at least one Fused Bicyclic Pyrazole Derivative, and methods of using the Fused Bicyclic Pyrazole Derivatives for treating or preventing a herpesvirus infection in a patient.

Abstract: The present disclosure provides computing systems in which respective quorums of computing nodes securely manage respective secrets associated with cryptographic ledgers according to threshold secret sharing schemes. In particular, membership in the quorums can be changed dynamically and unpredictability to improve security of the quorums against adversarial attacks in which adversaries attempt to compromise or gain control of the computing nodes. More specifically, by changing membership in the quorum dynamically and unpredictability, the ability of the adversary to control at any given time a threshold number of the current members of the quorum and gain access to the secret is dramatically reduced.

Abstract: The present disclosure provides computing systems in which respective quorums of computing nodes securely manage respective secrets associated with cryptographic ledgers according to threshold secret sharing schemes. In particular, membership in the quorums can be changed dynamically and unpredictability to improve security of the quorums against adversarial attacks in which adversaries attempt to compromise or gain control of the computing nodes. More specifically, by changing membership in the quorum dynamically and unpredictability, the ability of the adversary to control at any given time a threshold number of the current members of the quorum and gain access to the secret is dramatically reduced.

Abstract: The present disclosure provides computing systems in which respective quorums of computing nodes securely manage respective secrets associated with cryptographic ledgers according to threshold secret sharing schemes. In particular, membership in the quorums can be changed dynamically and unpredictability to improve security of the quorums against adversarial attacks in which adversaries attempt to compromise or gain control of the computing nodes. More specifically, by changing membership in the quorum dynamically and unpredictability, the ability of the adversary to control at any given time a threshold number of the current members of the quorum and gain access to the secret is dramatically reduced.

Abstract: A sandwich structure employs a core sheet including alternating peaks and valleys therein, and at least one outer face sheet including grooves or ribs therein. In another aspect, a sandwich structure includes at least one core and at least one adhesively bonded outer face sheet including elongated grooves or ribs formed therein. Yet another aspect of a sandwich structure has raised ridges bridging between adjacent peaks in a core sheet in one direction but not in a perpendicular direction, which synergistically interface, engage or contact with grooves or ribs formed in an outer face sheet.

Abstract: A container apparatus includes a sandwich structure. In another aspect, a sandwich structure of a container apparatus employs at least one core sheet including alternating peaks and valleys therein in addition to at least one adhesively bonded outer face sheet. Moreover, another aspect of a container apparatus includes a wheeled box trailer, an intermodal shipping container, a railroad car, or other box-like holding and transporting device. An inner container liner, such as a floor, or structural container frame rail is attached to a structural sandwich in another aspect. A joint or connection between adjacent sandwich structures and/or a sandwich structure and an elongated beam, for a container apparatus is also provided.

Abstract: A sandwich structure employs a core sheet including alternating peaks and valleys therein, and at least one outer face sheet including grooves or ribs therein. In another aspect, a sandwich structure includes at least one core and at least one adhesively bonded outer face sheet including elongated grooves or ribs formed therein. Yet another aspect of a sandwich structure has raised ridges bridging between adjacent peaks in a core sheet in one direction but not in a perpendicular direction, which synergistically interface, engage or contact with grooves or ribs formed in an outer face sheet.

Abstract: A container apparatus includes a sandwich structure. In another aspect, a cargo-securing or logistics track is attached to a sandwich structure of a container apparatus which employs at least one core sheet including alternating peaks and valleys therein in addition to at least one adhesively bonded outer face sheet. Yet another aspect of a container apparatus includes a depression in a sandwich structure adapted to receive a flush mounted track or post therein. Another aspect of a container apparatus includes a ship-lap and/or bent peripheral flange at a panel-to-panel interface seam.

Abstract: A sandwich structure employs a core sheet including alternating peaks and valleys therein, and at least one outer face sheet including grooves or ribs therein. In another aspect, a sandwich structure includes at least one core and at least one adhesively bonded outer face sheet including elongated grooves or ribs formed therein. Yet another aspect of a sandwich structure has raised ridges bridging between adjacent peaks in a core sheet in one direction but not in a perpendicular direction, which synergistically interface, engage or contact with grooves or ribs formed in an outer face sheet.

Abstract: A sandwich structure employs a core sheet including alternating peaks and valleys therein. In another aspect, a sandwich structure includes at least one metallic core and at least one adhesively bonded outer face sheet. Yet another aspect of a sandwich structure has raised ridges bridging between adjacent peaks in a core sheet in one direction but not in a perpendicular direction, thereby achieving different properties in the different sheet directions.

Abstract: A container apparatus includes a sandwich structure. In another aspect, a sandwich structure of a container apparatus employs at least one core sheet including alternating peaks and valleys therein in addition to at least one adhesively bonded outer face sheet. Moreover, another aspect of a container apparatus includes a wheeled box trailer, an intermodal shipping container, a railroad car, or other box-like holding and transporting device. An inner container liner, such as a floor, or structural container frame rail is attached to a structural sandwich in another aspect. A joint or connection between adjacent sandwich structures and/or a sandwich structure and an elongated beam, for a container apparatus is also provided.

Abstract: A sandwich structure employs a core sheet including alternating peaks and valleys therein. In another aspect, a sandwich structure includes at least one metallic core and at least one adhesively bonded outer face sheet. Yet another aspect of a sandwich structure has raised ridges bridging between adjacent peaks in a core sheet in one direction but not in a perpendicular direction, thereby achieving different properties in the different sheet directions.

Abstract: A container apparatus includes a sandwich structure. In another aspect, a cargo-securing or logistics track is attached to a sandwich structure of a container apparatus which employs at least one core sheet including alternating peaks and valleys therein in addition to at least one adhesively bonded outer face sheet. Yet another aspect of a container apparatus includes a depression in a sandwich structure adapted to receive a flush mounted track or post therein. Another aspect of a container apparatus includes a ship-lap and/or bent peripheral flange at a panel-to-panel interface seam.

Abstract: A method and system funding long-term data storage, retrieval, migration, and preservation services accessed over the internet, the services funded by an automated system seeking a target rate of return, input to the system, using pooled, one-time client payments of a client fee, where the rate of return is analyzed and referenced against pre-set criteria in a fund data store, with generated returns calculated and then apportioned so that distributed returns pay expenses incurred providing the data services, and non-distributed returns are reinvested to pay future expenses, all steps performed by a fund manager implemented as software executing on one or more computing devices or servers. A software-implemented database manager manages the data services, controlling data access by establishing an account record per client and then applying identifying information and criteria stored in various data stores.

Abstract: A sandwich structure employs a core sheet including alternating peaks and valleys therein, and at least one outer face sheet including grooves or ribs therein. In another aspect, a sandwich structure includes at least one core and at least one adhesively bonded outer face sheet including elongated grooves or ribs formed therein. Yet another aspect of a sandwich structure has raised ridges bridging between adjacent peaks in a core sheet in one direction but not in a perpendicular direction, which synergistically interface, engage or contact with grooves or ribs formed in an outer face sheet.

Abstract: A scribing tool is provided for scribing and marking linear lines along corrugated panels. The scribing tool comprises an elongated member adapted to rest substantially flushly against a corrugated panel, whereby the flanges of the tool bear against the panel to form linear lines along which to scribe or mark for subsequent cutting. The tool comprises a cross section with a web and an upper and lower flange. The flanges include outer edges that share matching corrugated profiles therealong, whereby the first or second side of the tool can be pressed against a corrugated panel and the flanges of the tool bear flushly thereagainst. Some embodiments of the tool include a tapering height along the tool length, various cross sections that allow for different corrugated edge patterns on opposite sides of the tool, different corrugated edge patterns for specific panels, as well as male or female edge patterns.

Abstract: A sandwich structure employs a core sheet including alternating peaks and valleys therein. In another aspect, a sandwich structure includes at least one metallic core and at least one adhesively bonded outer face sheet. Yet another aspect of a sandwich structure has raised ridges bridging between adjacent peaks in a core sheet in one direction but not in a perpendicular direction, thereby achieving different properties in the different sheet directions.

Abstract: A method and system funding long-term data storage, retrieval, and preservation services accessed over the internet, the data services funded by an automated system seeking a target rate of return, input to the system, using pooled, one-time client payments of a client fee (20a), where the rate of return is analyzed and referenced against pre-set criteria (50b 50c) in a fund data store (50), with generated returns calculated and then apportioned (20f) so that distributed returns pay expenses incurred providing the data services, and non-distributed returns are reinvested to pay future expenses, all steps performed by a fund manager (50a) implemented as software executing on one or more computing devices or servers. A software-implemented database manager (30a) manages the data services, controlling data access by establishing an account record per client and then applying identifying information and criteria stored in various data stores (14a 30b 30c 30d).