Abstract: Proteins (INSP141, INSP142, INSP143, and INSP144) identified as anthrax receptor-like proteins containing von Willebrand factor A (vWFA) and Anthrax receptor extracellular (ANT_IG) domains and the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease are described.

Abstract: This invention relates to a novel protein (INSP002), herein identified as a secreted protein that is a member of the Dan family of the cystine-knot fold cytokine superfamily and to the use of this protein and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.

Abstract: This invention relates to a novel protein (INSP002), herein identified as a secreted protein that is a member of the Dan family of the cystine-knot fold cytokine superfamily and to the use of this protein and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.

Abstract: This invention relates to novel proteins (herein termed INSP141, INSP142, INSP143, and INSP144), herein identified as anthrax receptor-like proteins containing von Willebrand factor A (vWFA) and Anthrax receptor extracellular (ANT_IG) domains and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.

Abstract: This present invention relates to a novel protein, termed INSP085, herein identified as an IL-8 like protein and to the use of this protein and nucleic acid sequence from the encoding genes in the diagnosis, prevention and treatment of disease.

Abstract: This present invention relates to a novel protein, termed INSP085, herein identified as an IL-8 like protein and to the use of this protein and nucleic acid sequence from the encoding genes in the diagnosis, prevention and treatment of disease.

Abstract: The invention relates to a feedback circuit for a transimpedance amplifier, which is typically used for converting an input current from a photodiode into an output voltage. The feedback circuit of the present invention linearizes the transconductance feedback, as the input current signal varies, by providing a constant current source for supplementing the DC feedback current through a bypass transistor, thereby reducing a variation in the low frequency cut off.

Abstract: A multiwell plate for microarraying comprising a self-sealing lower membrane and optionally also a self-sealing upper membrane. Spotting is performed by pushing a pin down through the liquid and then on to pierce the self-sealing lower membrane. A slide having an upper spotting surface is arranged under the well plate. The liquid sample forced through the lower membrane by the pin tip can thus be deposited directly onto the spotting surface. The pin is then withdrawn upwards through the lower membrane, which automatically reseals preventing further loss of liquid. The optional resealable upper membrane also prevents loss of sample liquid by evaporation and spillage. By contrast to the prior art, there is the major advantage that the pin head does not have to traverse between the well plate and slide to collect sample liquid, thus dramatically increasing operational speed for an automated microarraying apparatus employing the multiwell plate. Excellent spot reproducibility is also observed.

Abstract: A multiwell plate for microarraying comprising a self-sealing lower membrane and optionally also a self-sealing upper membrane. Spotting is performed by pushing a pin down through the liquid and then on to pierce the self-sealing lower membrane. A slide having an upper spotting surface is arranged under the well plate. The liquid sample forced through the lower membrane by the pin tip can thus be deposited directly onto the spotting surface. The pin is then withdrawn upwards through the lower membrane, which automatically reseals preventing further loss of liquid. The optional resealable upper membrane also prevents loss of sample liquid by evaporation and spillage. By contrast to the prior art, there is the major advantage that the pin head does not have to traverse between the well plate and slide to collect sample liquid, thus dramatically increasing operational speed for an automated microarraying apparatus employing the multiwell plate. Excellent spot reproducibility is also observed.

Abstract: An apparatus and method for externally managing data within an asynchronous pipeline. The asynchronous pipeline over which control is sought includes a data path and a control path. In accordance with the method of the present invention, a data tag value is assigned to the data prior to its entry into the asynchronous pipeline. The data tag value is sent into the control path at the same time the data is sent into its data path such that the data tag value passes through the asynchronous pipeline in parallel with the data to which it is assigned. At a given stage within the asynchronous pipeline, the data tag value is compared with a control tag value, and only in response to the data tag value matching the control tag value is the data permitted to pass to the next stage within the asynchronous pipeline.

Abstract: The present invention is an apparatus and method for eliminating parasitic bipolar transistor action in a Silicon on Insulator (SOI) Metal Oxide Semiconductor (MOS) device. In accordance with the invention a SOI electronic device and an active discharging device coupled to said SOI electronic device is provided to deactivate the parasitic bipolar transistor. The parasitic bipolar transistor action is deactivated by controlling the conduction of an active discharging device, said active discharging device being coupled to said SOI device.

Abstract: An apparatus for determining the statues of a shut-off valve arrangement forming part of a fuelling system of an engine comprises a metering valve arrangement comprising a metering valve member for regulating fuel flow from a pump to the engine and a position sensor for monitoring the position of the metering valve member. The shut-off valve arrangement is operable between open and closed positions and the metering valve arrangement is operable between a maximum flow position, in which the flow of fuel through the metering valve arrangement to the shut-off valve arrangement is a maximum, and a minimum flow position in which the flow of fuel through the metering valve arrangement to the shut-off valve arrangement is a minimum. The position of the metering valve member is controlled by controlling fuel pressure acting on the metering valve member.

Abstract: A method and apparatus are provided for implementing dynamic noise immunity and minimizing delay of complementary metal oxide semiconductor (CMOS) logic circuits. A method of logical effort is applied to the CMOS logic circuits. Selected circuits within the CMOS logic circuits are checked for noise immunity utilizing a noise test simulation to identify each selected circuit failing the noise test simulation. An electrical effort is fixed to a value for providing noise immunity for each identified selected circuit failing the noise test simulation. The method of logical effort is applied to each remaining selected circuit not failing the noise test simulation. The sequential steps are repeated for each remaining selected circuit not failing the noise test simulation until no selected circuit failing the noise test simulation is identified. The selected circuits that are checked for noise immunity include, for example, dynamic circuits and passgate circuits.

Abstract: During scan testing of logical and memory circuits, it is important to prevent a scan test error resulting from simultaneous switching of the values within chip logic. Scan testing, however, encompasses rapidly scanning in values into a register to detect if the register is properly functioning. A circuit is disclosed which looks at the n−1 values within the register and determines if the next scan in value would cause contention. If so, that value is blocked until the next scan in value would not cause contention with the n−1 values within the register. Practicably, the invention will allow only allowed values into the register and may allow a “hot one” value into the register every n−1 clock cycle. Feedback of the values in the register is provided to a logical AND function to determine if a differing bit value will be allowed to scan into the register.

Abstract: A zero-detection circuit is provided. The zero-detection circuit includes a plurality of transistor stacks. Each transistor stack includes an input transistor and a clocked transistor. Each of the plurality of input transistors receives a data input. An intermediate node is connected to the input transistor stacks. An output stage is coupled to the intermediate node providing an output. The output stage includes a bit selection control circuit receiving a bit selection signal. The bit selection control circuit provides a zero level output of the output stage responsive to a predefined bit selection signal. The transistor stacks comprise silicon-on-insulator (SOI) transistors.

Abstract: A circuit and a method to realize a programmable delay between two adjacent signal paths, each having a different timing domain. In a preferred embodiment, each signal path is a stage of domino logic and the programmable delay is positioned at the boundary to adjust the timing between the two stages. The delay is programmed depending upon the value of an input signal to be either a static delay and hence part of the first stage of domino logic; or a dynamic delay to be part of a subsequent stage of domino logic. Critical paths can easily be balanced after fabrication, either at wafer test or once the circuit is mounted on an integrated chip and then tested, with the programmable gate as disclosed herein.

Abstract: An apparatus and method for externally managing data within an asynchronous pipeline. The asynchronous pipeline over which control is sought includes a data path and a control path. In accordance with the method of the present invention, a data tag value is assigned to the data prior to its entry into the asynchronous pipeline. The data tag value is sent into the control path at the same time the data is sent into its data path such that the data tag value passes through the asynchronous pipeline in parallel with the data to which it is assigned. At a given stage within the asynchronous pipeline, the data tag value is compared with a control tag value, and only in response to the data tag value matching the control tag value is the data permitted to pass to the next stage within the asynchronous pipeline.

Abstract: A charge booster for a node in a dynamic logic circuit having a logic function evaluation network that includes a switching network and a dominant input switching device adapted to receive a plurality of input signals. In one aspect of the present invention, a precharge transistor is first turned on by a clock signal during a precharge phase to precharge the node that is coupled to an output of the dynamic logic circuit. Concurrently, during the precharge phase, an evaluate transistor is turned off. Next, during an evaluate phase, the evaluate transistor is turned on by the control signal, i.e., clock signal, permitting the logic function evaluation network to perform the predefined logic function in accordance with the input signals received by the logic function evaluation network. The logic function evaluation network selectively charges or discharges the node to a voltage level based on the predefined logic function.

Abstract: The present invention is an apparatus and method for eliminating parasitic bipolar transistor action in a Silicon on Insulator (SOI) Metal Oxide Semiconductor (MOS) device. In accordance with the invention a SOI electronic device and an active discharging device coupled to said SOI electronic device is provided to deactivate the parasitic bipolar transistor. The parasitic bipolar transistor action is deactivated by controlling the conduction of an active discharging device, said active discharging device being coupled to said SOI device.

Abstract: An apparatus for determining the statues of a shut-off valve arrangement forming part of a fuelling system of an engine comprises a metering valve arrangement comprising a metering valve member for regulating fuel flow from a pump to the engine and a position sensor for monitoring the position of the metering valve member. The shut-off valve arrangement is operable between open and closed positions and the metering valve arrangement is operable between a maximum flow position, in which the flow of fuel through the metering valve arrangement to the shut-off valve arrangement is a maximum, and a minimum flow position in which the flow of fuel through the metering valve arrangement to the shut-off valve arrangement is a minimum. The position of the metering valve member is controlled by controlling fuel pressure acting on the metering valve member.