Patents by Inventor Douglas E. Brough

Douglas E. Brough has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hepatitis B vaccines and uses of the same
    Patent number: 12234261
    Abstract: Provided herein are engineered hepatitis B virus (HBV) molecular vaccine constructs. Vaccine constructs can also include ligand-inducible engineered gene switch systems for modulating expression of heterologous genes, such as a cytokines, in host cells.
    Type: Grant
    Filed: December 2, 2022
    Date of Patent: February 25, 2025
    Assignee: Precigen, Inc.
    Inventors: Douglas E. Brough, Cheryl G. Bolinger, Ramya Yarlagadda, Vinodhbabu Kurella, Prabakaran Ponraj, Simon Metenou, Kuan-Fu Ding
  • NOVEL ADENOVIRUS VACCINE THERAPY FOR THE TREATMENT OF RECURRENT RESPIRATORY PAPILLOMATOSIS
    Publication number: 20240398926
    Abstract: Multi-antigenic human papilloma virus (HPV) molecular vaccine constructs for use and treatment of HPV-associated disorders and pathologies, such as HPV molecular vaccines targeting HPV6- and HPV11-associated recurrent respiratory papillomatosis (RRP).
    Type: Application
    Filed: May 22, 2024
    Publication date: December 5, 2024
    Applicant: PRECIGEN, INC.
    Inventors: Douglas E. BROUGH, Damodar R. ETTYREDDY, Qi YANG, Chen WANG
  • HUMAN PAPILLOMAVIRUS VACCINES AND USES OF THE SAME
    Publication number: 20240390475
    Abstract: Multi-antigenic human papilloma virus (HPV) molecular vaccine constructs for use and treatment of HPV-associated disorders and pathologies, such as HPV molecular vaccines targeting HPV16-, HPV18-, and HPV-45-associated pathologies.
    Type: Application
    Filed: May 22, 2024
    Publication date: November 28, 2024
    Applicant: PRECIGEN, INC.
    Inventors: Douglas E. BROUGH, Cheryl BOLINGER, Ramya YARLAGADDA, Vinodhbabu KURELLA, Prabakaran PONRAJ, Simon METENOU, Kuan-fu DING
  • Human Papilloma Virus Vaccines and Uses of the Same for HPV Associated Diseases
    Publication number: 20240173396
    Abstract: Provided herein are multi-antigenic human papilloma virus (HPV) molecular vaccine constructs for use and treatment of HPV associated disorders and pathologies; such as HPV molecular vaccines targeting HPV6 and HPV11 associated pathologies.
    Type: Application
    Filed: November 23, 2021
    Publication date: May 30, 2024
    Inventors: Douglas E. BROUGH, Damodar R. ETTYREDDY, Qi YANG, Chen WANG
  • HEPATITIS B VACCINES AND USES OF THE SAME
    Publication number: 20230279057
    Abstract: Provided herein are engineered hepatitis B virus (HBV) molecular vaccine constructs. Vaccine constructs can also include ligand-inducible engineered gene switch systems for modulating expression of heterologous genes, such as a cytokines, in host cells.
    Type: Application
    Filed: December 2, 2022
    Publication date: September 7, 2023
    Applicant: Precigen, Inc.
    Inventors: Douglas E. BROUGH, Cheryl G. BOLINGER, Ramya YARLAGADDA, Vinodhbabu KURELLA, Prabakaran PONRAJ, Simon METENOU, Kuan-Fu DING
  • Hepatitis B vaccines and uses of the same
    Patent number: 11608362
    Abstract: Provided herein are engineered hepatitis B virus (HBV) molecular vaccine constructs. Vaccine constructs can also include ligand-inducible engineered gene switch systems for modulating expression of heterologous genes, such as a cytokines, in host cells.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: March 21, 2023
    Assignee: Precigen, Inc.
    Inventors: Douglas E. Brough, Cheryl G. Bolinger, Ramya Yarlagadda, Vinodhbabu Kurella, Prabakaran Ponraj, Simon Metenou, Kuan-Fu Ding
  • Simian (gorilla) adenovirus or adenoviral vectors and methods of use
    Patent number: 11359214
    Abstract: The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein.
    Type: Grant
    Filed: August 25, 2020
    Date of Patent: June 14, 2022
    Assignee: GenVec, Inc.
    Inventors: Douglas E. Brough, Jason G. D. Gall, Duncan McVey
  • Adenoviral vector encoding human atonal homolog-1 (HATH1)
    Patent number: 11279951
    Abstract: The invention is directed to a replication-deficient adenoviral vector comprising a nucleic acid sequence encoding a human atonal homolog-1 (Hath1) protein operably linked to a human glial fibrillary acidic protein (GFAP) promoter. The invention also is directed to a composition and method utilizing the adenoviral vector to generate sensory cells in the inner ear of a human.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: March 22, 2022
    Assignee: GenVec, Inc.
    Inventors: Douglas E. Brough, Damodar R. Ettyreddy
  • Adenovectors for delivery of therapeutic genetic material into T cells
    Patent number: 11155832
    Abstract: The invention provides adenoviral vectors and compositions for the highly efficient transduction of T cells.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: October 26, 2021
    Assignee: GenVec, Inc.
    Inventors: Sebastien M. Maloveste, Damodar Ettyreddy, Douglas E. Brough
  • ADENOVECTORS FOR DELIVERY OF THERAPEUTIC GENETIC MATERIAL INTO T CELLS
    Publication number: 20210301303
    Abstract: The invention provides adenoviral vectors and compositions for the highly efficient transduction of T cells.
    Type: Application
    Filed: April 13, 2021
    Publication date: September 30, 2021
    Applicant: GenVec, Inc.
    Inventors: Sebastien M. Maloveste, Damodar Ettyreddy, Douglas E. Brough
  • MODIFIED SEROTYPE 28 ADENOVIRAL VECTORS
    Publication number: 20210269827
    Abstract: The invention provides a replication-deficient serotype 28 adenoviral vector characterized by comprising a portion of a serotype 45 adenoviral hexon protein and/or a portion of a serotype 45 fiber protein in place of the endogenous serotype 28 hexon and/or fiber protein.
    Type: Application
    Filed: March 12, 2021
    Publication date: September 2, 2021
    Applicant: GenVec, Inc.
    Inventors: Lisa Wei, Douglas E. Brough, C. Richter King
  • Affenadenovirus (gorilla) or adenoviral vectors and methods of use
    Patent number: 11034975
    Abstract: The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexone protein, and/or fiber protein.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: June 15, 2021
    Assignee: GenVec, Inc.
    Inventors: Jason G. D. Gall, Duncan McVey, Douglas E. Brough
  • Modified serotype 28 adenoviral vectors
    Patent number: 10947560
    Abstract: The invention provides a replication-deficient serotype 28 adenoviral vector characterized by comprising a portion of a serotype 45 adenoviral hexon protein and/or a portion of a serotype 45 fiber protein in place of the endogenous serotype 28 hexon and/or fiber protein.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: March 16, 2021
    Assignee: GenVec, Inc.
    Inventors: Lisa Wei, Douglas E. Brough, C. Richter King
  • SIMIAN (GORILLA) ADENOVIRUS OR ADENOVIRAL VECTORS AND METHODS OF USE
    Publication number: 20210040502
    Abstract: The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein.
    Type: Application
    Filed: August 25, 2020
    Publication date: February 11, 2021
    Applicant: GenVec, Inc.
    Inventors: Douglas E. Brough, Jason G.D. Gall, Duncan McVey
  • HUMAN PAPILLOMAVIRUS VACCINES AND USES OF THE SAME
    Publication number: 20210024586
    Abstract: Provided herein are engineered human papilloma virus (HPV) molecular vaccine constructs. Vaccine constructs can also include ligand-inducible engineered gene switch systems for modulating expression of heterologous genes, such as a cytokines, in host cells.
    Type: Application
    Filed: March 6, 2019
    Publication date: January 28, 2021
    Applicants: Precigen, Inc., PGEN Therapeutics, Inc.
    Inventors: Douglas E. BROUGH, Cheryl G. BOLINGER, Ramya YARLAGADDA, Vinodhbabu KURELLA, Ponraj PRABAKARAN, Simon METENOU, Kuan-Fu DING
  • HEPATITIS B VACCINES AND USES OF THE SAME
    Publication number: 20210015911
    Abstract: Provided herein are engineered hepatitis B virus (HBV) molecular vaccine constructs. Vaccine constructs can also include ligand-inducible engineered gene switch systems for modulating expression of heterologous genes, such as a cytokines, in host cells.
    Type: Application
    Filed: March 6, 2019
    Publication date: January 21, 2021
    Applicants: Precigen, Inc., PGEN Therapeutics, Inc.
    Inventors: Douglas E. BROUGH, Cheryl G. BOLINGER, Ramya YARLAGADDA, Vinodhbabu KURELLA, Ponraj PRABAKARAN, Simon METENOU, Kuan-Fu DING
  • Affenadenovirus (gorilla) or adenoviral vectors and methods of use
    Patent number: 10792376
    Abstract: The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: October 6, 2020
    Assignee: GenVec, Inc.
    Inventors: Duncan McVey, Douglas E. Brough, Jason G. D. Gall
  • Simian (gorilla) adenovirus or adenoviral vectors and methods of use
    Patent number: 10787682
    Abstract: The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: September 29, 2020
    Assignee: GenVec, Inc.
    Inventors: Douglas E. Brough, Jason G. D. Gall, Duncan McVey
  • Malaria antigens and methods of use
    Patent number: 10780153
    Abstract: The invention is directed to a composition comprising one or more polypeptides or one or more nucleic acid sequences that can induce a protective immune response against Plasmodium species that infect humans. The invention also is directed to a method of using such compositions to induce a protective immune response against a Plasmodium parasite in a mammal.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: September 22, 2020
    Assignee: GenVec, Inc.
    Inventors: Ping Chen, Duncan McVey, Douglas E. Brough, Joseph Bruder
  • Method for propagating adenoviral vectors encoding inhibitory gene products
    Patent number: 10640776
    Abstract: The invention provides a method of propagating an adenoviral vector. The method comprises (a) providing a cell comprising a cellular genome comprising a nucleic acid sequence encoding a tetracycline operon repressor protein (tetR), and (b) contacting the cell with an adenoviral vector comprising a heterologous nucleic acid sequence encoding a toxic protein. The heterologous nucleic acid sequence is operably linked to a promoter and one or more tetracycline operon operator sequences (tetO), and expression of the heterologous nucleic acid sequence is inhibited in the presence of tetR, such that the adenoviral vector is propagated. The invention also provides a system comprising the aforementioned cell and adenoviral vector.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: May 5, 2020
    Assignee: GenVec, Inc.
    Inventors: Jason G. D. Gall, Douglas E. Brough, C. Richter King