Abstract: Described herein are compounds that inhibit ALK2 and its mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.

Abstract: A controllable or selectable coupling assembly includes a plurality of forward locking elements, at least one reverse locking element and first and second coupling members supported for relative rotation about a common rotational axis. The coupling members include a first, second and third coupling faces. The first coupling face has a set of forward pockets angularly spaced about the axis. The second coupling face has a set of reverse locking formations adapted for abutting engagement with the at least one reverse locking element. The third coupling face opposes the first coupling face and has a set of forward locking formations. Either forward backlash is a non-zero integer multiple of reverse backlash or the reverse backlash is a non-zero integer multiple of the forward backlash to prevent the coupling assembly from inadvertently binding in both directions (i.e. a “lock-lock” condition) about the axis.

Abstract: A controllable or selectable coupling assembly includes a plurality of forward locking elements, at least one reverse locking element and first and second coupling members supported for relative rotation about a common rotational axis. The coupling members include a first, second and third coupling faces. The first coupling face has a set of forward pockets angularly spaced about the axis. The second coupling face has a set of reverse locking formations adapted for abutting engagement with the at least one reverse locking element. The third coupling face opposes the first coupling face and has a set of forward locking formations. Either forward backlash is a non-zero integer multiple of reverse backlash or the reverse backlash is a non-zero integer multiple of the forward backlash to prevent the coupling assembly from inadvertently binding in both directions (i.e. a “lock-lock” condition) about the axis.

Abstract: A controllable or selectable coupling assembly includes a plurality of forward locking elements, at least one reverse locking element and first and second coupling members supported for relative rotation about a common rotational axis. The coupling members include a first, second and third coupling faces. The first coupling face has a set of forward pockets angularly spaced about the axis. The second coupling face has a set of reverse locking formations adapted for abutting engagement with the at least one reverse locking element. The third coupling face opposes the first coupling face and has a set of forward locking formations. Either forward backlash is a non-zero integer multiple of reverse backlash or the reverse backlash is a non-zero integer multiple of the forward backlash to prevent the coupling assembly from inadvertently binding in both directions (i.e. a “lock-lock” condition) about the axis.