Abstract: Provided herein are pharmaceutically acceptable compositions containing a selective cyclooxygenase-2 (COX-2) inhibitor (coxib) and optionally buprenorphine. In particular, compositions containing a coxib formulated for oral, topical or subcutaneous administration to treat pain or inflammation are described.

Abstract: A molded structural bicycle component design, such as wheels and frames, which may incorporate complementary halves and at least one shear bond to allow efficient manufacturing and assembly. The molded design which may be applied in a host of different applications, including a bicycle frame and wheel, where demanding loads exist in normal use. Details of the joint and its design are provided. Integral bearings, foam tire adaptations, symmetrically opposite designs, and compression bonding techniques are described. Various cross sections may be made at different stress areas. A method of inserting a reinforcing tube in various high stress areas is also described. A host of bonding techniques including the use of electromagnetically active material are accommodated by the designs. The design may include the use of spacers in the vicinity where methods of retention of accessories or components require compressing from both sides such as the wheels, head tube, bottom bracket, and suspension attachment.

Abstract: A molded wheel design may incorporate identical halves and a shear bond to allow efficient manufacturing and assembly. The wheel design which may be applied in a host of different applications including a bicycle wheel where demanding loads exist in normal use. Integral bearings, foam tire adaptations, symmetrically opposite designs, and compression bonding techniques are described. A host of bonding techniques including the use of electromagnetically active material are accommodated by the designs. Spacers in the vicinity of the hub portion and semicircular boundaries so as to define a valve stem hole after assembly can be included.

Abstract: A game racket frame such as a tennis racket frame having controlled stiffness properties and light weight making it possible to selectively add weight to the racket at the region in which such weight will do the most good, namely, along the transverse axis of the stringing area. The racket frame itself comprises an integral structure including a head portion, a throat portion and a handle portion, the structure being composed of high modulus fibers such as graphite, glass, boron or the like, in a matrix of a synthetic resin. The frame has a non-uniform cross-sectional configuration and a taper whereby the thickness of the handle portion is greater than the thickness in the head portion, and the thickness of the throat is intermediate that of the handle portion and the head portion. The frame is such as to provide a tapered beam with the greatest area moment of inertia where the bending moments are highest.

Abstract: This invention is concerned with a tennis racket frame which comprises a pair of channel-shaped members in interengaging relationship, the channel-shaped members forming the faces of the head portion of the racket frame, and the sidewalls of each of the members having apertures therein in alignment to provide string holes therein. The racket frame is preferably composed of a synthetic resinous material which may be integrally reinforced with high modulus reinforcing fibers, or reinforced by attached facings of high strength, high modulus materials.